Results 51 to 60 of about 114,454,660 (263)

PLACENTAL URIC ACID TRANSPORTER GLUT9 IS MODULATED BY FREE IODINE [PDF]

, 2014
PLACENTAL URIC ACID TRANSPORTER GLUT9 IS MODULATED BY FREE IODINE Objectives: Materno-fetal transplacental transport is crucial for the fetal well-being.
Fine, Michael, Baumann, Marc Ulrich, Lüscher, Benjamin, Hediger, Matthias, Albrecht, Christiane, Marini, Camilla, Surbek, Daniel, Clemençon, Benjamin   +7 more
core  

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

Lycium barbarum polysaccharides protect mice from hyperuricaemia through promoting kidney excretion of uric acid and inhibiting liver xanthine oxidase

Pharmaceutical Biology, 2020
Context Lycium barbarum L. (Solanaceae) polysaccharides (LBPs) are important active constituents that have demonstrated kidney protection. Objective This study investigated the effect of LBPs on hyperuricaemia and explored the underlying mechanism in ...
Xin Yu, Lu Zhang, Ping Zhang, Jia Zhi, Ruinan Xing, Lianqi He   +5 more
doaj   +1 more source

Genetic Basis of the Epidemiological Features and Clinical Significance of Renal Hypouricemia

Biomedicines, 2022
A genetic defect in urate transporter 1 (URAT1) is the major cause of renal hypouricemia (RHUC). Although RHUC is detected using a serum uric acid (UA) concentration
Masayuki Hakoda, Kimiyoshi Ichida
doaj   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source

Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway

BMC Cardiovascular Disorders, 2023
Objective Previous studies have revealed associations between hyperuricemia and microvascular diseases, but the association between hyperuricemia and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to elucidate the pathogenesis
Jen-Chun Wang, Shih-Hung Tsai, Hsiao-Ya Tsai, Shing-Jong Lin, Po-Hsun Huang   +4 more
doaj   +1 more source

Modulation of uric acid transport in human endothelial cells

, 2022
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Rongen, Prof. Dr. G.A. (Radboudumc) ORCID=0000-0002-3064-3192
core   +1 more source

Bridging Biosensing and Hardware‐Level Data Security With a Conjugated Radical Polymer

Advanced Materials, EarlyView.
A conjugated radical polymer provides two complementary functions within a common material platform: sensitive dopamine biosensing and device‐specific stochastic electrical responses for security. The work demonstrates a materials‐based approach for combining bioelectronic signal acquisition with hardware‐level authentication while maintaining the ...
Hoyeon Lee, Jaehyoung Ko, Dinh Cung Tien Nguyen, Yeong Kwon Kim, Daeun Kim, Soo Jin Cho, Sung Gap Im, Byung Chul Jang, Byung Joon Moon, Yongho Joo   +9 more
wiley   +1 more source

URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease

iScience, 2023
Summary: We recently reported that the selective inhibition of urate transporter-1 (URAT1), which is primarily expressed in the kidneys, ameliorates insulin resistance by attenuating hepatic steatosis and improving brown adipose tissue function in diet ...
Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Rei Yasutake, Akira Yoshii, Haruka Kimura, Yusuke Kashiwagi, Toshikazu D. Tanaka, Masayuki Shimoda, Michihiro Yoshimura   +10 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source