Journal of Agromedicine and Medical Sciences (AMS), 2017 Diabetes mellitus (DM) is a metabolic disorder with increasing mortality rate. Decrease in GLUT-4 levels was found in diabetics resulting in an increase in postprandial blood glucose levels.
Adelia Handoko +2 more
doaj +5 more sources
α-Pinene, a Main Component of Pinus Essential Oils, Enhances the Expression of Insulin-Sensitive Glucose Transporter Type 4 in Murine Skeletal Muscle Cells. [PDF]
Int J Mol SciGlucose transporter-4 (GLUT4) represents the major glucose transporter isoform responsible for glucose uptake into insulin-sensitive cells, primarily in skeletal muscle and adipose tissues. In insulin-resistant conditions, such as type 2 diabetes mellitus, GLUT4 expression and/or translocation to the cell plasma membrane is reduced, compromising cell ...
Feriotto G +6 more
europepmc +4 more sources
Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes
IUBMB Life, 2007 AbstractThe gene expression of glucose transporter type 4 isoform (GLUT4) is known to be controlled by metabolic, nutritional, or hormonal status. Understanding the molecular mechanisms governing GLUT4 gene expression is critical, because glucose disposal in the body depends on the activities of GLUT4 in the muscle and adipocytes.
Im, SS +4 more
openaire +4 more sources
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes [PDF]
Clinics, 2013 OBJECTIVES: We evaluated the effects of aerobic exercise training without dietary changes on cardiovascular and metabolic variables and on the expression of glucose transporter Type 4 in rats with metabolic syndrome.
Paula Wesendonck Caponi +6 more
doaj +2 more sources
Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San in db/db Mice via Activation of PI3K/Akt and AMPK Pathways [PDF]
Frontiers in Pharmacology, 2017 This study was to investigate the anti-diabetic effects and molecular mechanisms of Tang-Kang-Fu-San (TKFS), a traditional Tibetan medicine, in treating type 2 diabetes mellitus of spontaneous diabetic db/db mice.
Bailu Duan +8 more
doaj +2 more sources
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. [PDF]
Journal of Clinical Investigation, 1997 Glucose transporter type 4 (GLUT4) is insulin responsive and is expressed in striated muscle and adipose tissue. To investigate the impact of a partial deficiency in the level of GLUT4 on in vivo insulin action, we examined glucose disposal and hepatic glucose production (HGP) during hyperinsulinemic clamp studies in 4-5-mo-old conscious mice with one ...
L, Rossetti +6 more
openaire +3 more sources
Renin-Angiotensin System Antagonism Protects the Diabetic Heart from Ischemia/Reperfusion Injury in Variable Hyperglycemia Duration Settings by a Glucose Transporter Type 4-Mediated Pathway. [PDF]
Pharmaceuticals (Basel), 2023 Background: Diabetes mellitus (DM) is a risk factor for cardiovascular diseases, specifically, the ischemic heart diseases (IHD). The renin–angiotensin system (RAS) affects the heart directly and indirectly.
Al-Kouh A, Babiker F, Al-Bader M.
europepmc +2 more sources
Medical Journal of BabylonBackground: Type 2 diabetes mellitus (T2DM) is a condition that requires careful and mindful management, as well as prediabetes is a serum health condition that usually does not have any signs or symptoms insulin resistance is a global problem and the ...
Ahmed Abed Kadhem Al-Saedy +2 more
doaj +2 more sources
Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation
Food Science and Human Wellness, 2023 Nuciferine contained in lotus leaves have been confirmed to have the effect of ameliorating hyperlipemia and hyperglycemia. A laser scanning confocal microscope was used to track the translocation of glucose transporter 4 (GLUT4) in L6 cells and the ...
Tongxi Zhou +6 more
doaj +1 more source