Results 31 to 40 of about 181,335 (186)

The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes

FEBS Open Bio, 2014
The di-peptide Trp-His (WH) has vasorelaxant and anti-atherosclerotic functions. We hypothesized that WH has multiple biological functions and may aid AMP-activated protein kinase (AMPK) activation and affect the glucose transport system in skeletal ...
Minoru Soga, Ayaka Ohashi, Megumi Taniguchi, Toshiro Matsui, Takanori Tsuda   +4 more
doaj   +1 more source

4-Phenylbutyric Acid Increases GLUT4 Gene Expression through Suppression of HDAC5 but not Endoplasmic Reticulum Stress

Cellular Physiology and Biochemistry, 2014
Background: The chemical chaperone 4-phenylbutyric acid (4-PBA) has been shown to relieve endoplasmic reticulum (ER) stress. Therefore, it improves insulin sensitivity and promotes glucose metabolism in skeletal muscle. Glucose transporter type 4 (GLUT4),
Hailong Hu, Li Li, Changlin Wang, Hongjuan He, Ke Mao, Xiao Ma, Ruoyu Shi, Yuri Oh, FengWei Zhang, Ying Lu, Qiong Wu, Ning Gu   +11 more
doaj   +1 more source

Symposium 10: Muscle

Revista de la Sociedad Argentina de Diabetes, 2020
Symposium 10: Insulin resistance: from pathophysiology to treatment Muscle The main action of the insulin in the muscle is that of promoting the entrance of glucose to the myocyte through the glucose transporter type 4 (GLUT-4) and its storage as an ...
Juan M. Corvalán
doaj   +1 more source

Neuregulin-1β increases glucose uptake and promotes GLUT4 translocation in palmitate-treated C2C12 myotubes by activating PI3K/AKT signaling pathway

Frontiers in Pharmacology, 2023
Insulin resistance (IR) is a feature of type 2 diabetes (T2DM) accompanied by reduced glucose uptake and glucose transporter 4 (GLUT4) translocation by skeletal muscle.
Meirong Yu, Shuang Wu, Chao Gong, Lianhua Chen   +3 more
doaj   +1 more source

Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation [PDF]

, 2018
Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER ...
Wong, Rachel H. X., Howe, Peter R. C., Rachel H. X. Wong, Peter R. C. Howe   +3 more
core   +3 more sources

Leucine-rich repeat kinase 2 negatively regulates glucose tolerance via regulation of membrane translocation of Glucose transporter type 4 in adipocytes

, 2022
Abstract Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD). However, the physiological significance of this association is unclear.
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Shun Tamaki, Rei Kawashima, Tatsunori Maekawa, Yoshifumi Kurosaki, Fumiaki Kojima, Takafumi Ichikawa   +13 more
openaire   +1 more source

Scopolin Prevents Adipocyte Differentiation in 3T3-L1 Preadipocytes and Weight Gain in an Ovariectomy-Induced Obese Mouse Model [PDF]

, 2020
Obesity is prevalent in modern human societies. We examined the anti-obesity effects of scopolin on adipocyte differentiation in preadipocyte 3T3-L1 cells and weight loss in an ovariectomy (OVX)-induced obese mouse model.
Jeong, SY, Lee, CG, Kim, J, Park, E, Lim, E, Yeo, S   +5 more
core   +2 more sources

Hyperbaric Oxygen Ameliorates Insulin Sensitivity by Increasing GLUT4 Expression in Skeletal Muscle and Stimulating UCP1 in Brown Adipose Tissue in T2DM Mice

Frontiers in Endocrinology, 2020
Hyperbaric oxygen (HBO) therapy is a treatment modality useful for diseases. Hypoxia could stimulate the induction of insulin resistance. Therefore, we sought to determine whether hyperbaric oxygen would ameliorate insulin sensitivity by promoting ...
Yuan Liu, Di Zhang, Junhua Yuan, Limin Song, Caishun Zhang, Qian Lin, Manwen Li, Zhi Sheng, Zhengye Ma, Fengyuan Lv, Guangkai Gao, Jing Dong, Jing Dong   +12 more
doaj   +1 more source

Lipoprotein Particles as Shuttles for Hydrophilic Cargo

, 2023
Lipoprotein particles (LPs) are excellent transporters and have been intensively studied in cardiovascular diseases, especially regarding parameters such as their class distribution and accumulation, site-specific delivery, cellular internalization, and ...
Markus Axmann, Bettina Schwarzinger, Julian Weghuber, Florian Weber, Andreas Horner, Birgit Plochberger   +5 more
core   +1 more source

Transient Silencing of a Type IV P-Type ATPase, Atp10c, Results in Decreased Glucose Uptake in C2C12 Myotubes

Journal of Nutrition and Metabolism, 2012
Atp10c is a strong candidate gene for diet-induced obesity and type 2 diabetes. To identify molecular and cellular targets of ATP10C, Atp10c expression was altered in vitro in C2C12 skeletal muscle myotubes by transient transfection with an Atp10c ...
S. E. Hurst, S. C. Minkin, J. Biggerstaff, M. S. Dhar   +3 more
doaj   +1 more source