Results 51 to 60 of about 181,335 (186)
Molecules, 2021 Although the hypoglycemic potential of brewer’s yeast extract has been reported, there is limited information pertaining to the hypoglycemic ingredients of Saccharomyces pastorianus extract and their mechanisms of action available.
Chien-Hui Wu +4 more
doaj +1 more source
Figure 3: KLF Isoforms That Control Metabolism in Skeletal Muscles
, 2019 Summary of KLF isoforms and metabolic pathways involved in skeletal muscle biology. A detailed description of the pathways involved in included in the text. Figure was produced using Servier Medical Art (http://www.servier.com/).
Matthew Hoffman (5916764) +3 more
core +1 more source
Effects of the sodium–glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b–4 chronic kidney disease [PDF]
Nephrology Dialysis Transplantation, 2018 The sodium-glucose co-transporter 2 inhibitor dapagliflozin decreases haemoglobin A1c (HbA1c), body weight, blood pressure (BP) and urinary albumin:creatinine ratio (UACR) in patients with type 2 diabetes. The efficacy and safety of this drug have not been properly defined in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease (CKD).In
Dekkers, CCJ +5 more
openaire +6 more sources
A cell-based fluorescent glucose transporter assay for SGLT2 inhibitor discovery
Acta Pharmaceutica Sinica B, 2013 The sodium/glucose cotransporter 2 (SGLT2) is responsible for the majority of glucose reabsorption in the kidney, and currently, SGLT2 inhibitors are considered as promising hypoglycemic agents for the treatment of type 2 diabetes mellitus.
Yi Huan +4 more
doaj +1 more source
Potential for combination of dipeptidyl peptidase‐4 inhibitors and sodium‐glucose co‐transporter‐2 inhibitors for the treatment of type 2 diabetes [PDF]
Diabetes, Obesity and Metabolism, 2015 In individuals with advanced type 2 diabetes ( T2DM ), combination therapy is often unavoidable to maintain glycaemic control. Currently metformin is considered the first line of defence, but many patients experience gastrointestinal adverse events, necessitating an alternative treatment ...
openaire +2 more sources
, 2019 • In the heart, SUR2 couples with a potassium channel to form an adenosine triphosphate–sensitive complex that responds to the energy state of the cell.• The authors deleted SUR2 in adult cardiomyocytes and found a shift of the heart toward glycolytic ...
Michele Hadhazy (2697553) +9 more
core +1 more source
Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4)
Skeletal MuscleBackground Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown.
Tyler J. Sermersheim +5 more
doaj +1 more source
, 2014 Hexokinase (HK), 6-phosphofructo-1-kinase (6PFK), pyruvate kinase (PK) and glucose transporter type 4 (GLUT4) mRNA levels were measured using real-time quantitative RT-PCR. Expression values were normalized by β-actin-transcripts.
Biju Sam Kamalam (466579) +5 more
core +1 more source
Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise [PDF]
, 2016 Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal ...
Youngju Song, Kangok Cho, Daekeun Kwon
core
, 2019 EPA, an omega-3 polyunsaturated fatty acid, exerts beneficial effects on human health. However, the molecular mechanisms underlying EPA function are poorly understood. The object was to illuminate molecular mechanism underlying EPA’s role. Here, 1H-
Miso Nam +5 more
core +2 more sources