Results 41 to 50 of about 181,335 (186)

Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells

Frontiers in Pharmacology, 2019
Glucose transporter 4 (GLUT4) is involved in regulating glucose uptake in striated muscle, liver, and adipose tissue. Neferine is a dibenzyl isoquinoline alkaloid derived from dietary lotus seeds and has multiple pharmacological effects.
Ping Zhao, Ping Zhao, Ping Zhao, Di Tian, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Jinhua Shen, Qing-Hua Liu, Qing-Hua Liu, Xinzhou Yang, Xinzhou Yang   +12 more
doaj   +1 more source

Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type

Scientific Reports, 2023
This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents.
Hyo Jin Kim, Munki Choo, Hyuk Nam Kwon, Kyung Don Yoo, Yunmi Kim, Bodokhsuren Tsogbadrakh, Eunjeong Kang, Sunghyouk Park, Kook-Hwan Oh   +8 more
doaj   +1 more source

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. [PDF]

, 2019
Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson's disease. The physiological function of LRRK2 and molecular mechanism underlying the pathogenic role of LRRK2 mutations remain uncertain.
Gasser, T., Biskup, S., Wenninger-Weinzierl, Andrea, Funk, Natalja, Wurst, W., Ott, T., Kuehn, Ralf, Vogt Weisenhorn, D.M., Munz, Marita, Wenninger-Weinzierl, A., Vogt-Weisenhorn, D., Brockmann, Kathrin, Brockmann, K., Kühn, R., Biskup, Saskia, Funk, N., Vogt-Weisenhorn, Daniela, Giesert, F., Ott, Thomas, Wurst, Wolfgang, Gasser, Thomas, Giesert, Florian, Munz, M.   +22 more
core   +1 more source

Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications

Cardiovascular Diabetology, 2021
Background Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline transporter 1 ...
Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare   +14 more
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bryant, Nia J., Cassie Welburn, Welburn, Cassie R., Nia Bryant, Gould, Gwyn W., Sadler, Jessica B. A., Jessica Sadler, Gwyn Gould, Sadler, Jessica B.A.   +8 more
core   +1 more source

Intracerebroventricular Injection of Alarin Increased Glucose Uptake in Skeletal Muscle of Diabetic Rats. [PDF]

PLoS ONE, 2015
In order to investigate the central effect of alarin on glucose uptake, we administered alarin and/ or its inhibitor, ala6-25Cys into the cerebral ventricles of the type 2 diabetic rats.
Zhenwen Zhang, Yongkang Wu, Shudong Sheng, Lili Guo, Biao He, Penghua Fang, Mingyi Shi, Ping Bo, Yan Zhu   +8 more
doaj   +1 more source

Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle

Frontiers in Endocrinology, 2022
Insulin-stimulated glucose uptake in skeletal muscle is of fundamental importance to prevent postprandial hyperglycemia, and long-term deficits in insulin-stimulated glucose uptake underlie insulin resistance and type 2 diabetes.
Jinhee Hwang, Debbie C. Thurmond
doaj   +1 more source

Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats [PDF]

, 2021
Training induces a number of healthy effects including a rise in skeletal muscle (SKM) glucose uptake. These adaptations are at least in part due to the reactive oxygen species produced within SKM, which is in agreement with the notion that antioxidant
Rodríguez Huertas, Jesús Francisco
core   +1 more source

Glucose Transporter Type 4 Redistribution on the Membrane Induced by Insulin through Akt in Hydrocortisone Treatment in Rat Skeletal Muscles

The Chinese Journal of Physiology, 2015
Hydrocortisone is a growth hormone frequently used in the treatment of low back pain. Hydrocortisone treatment has an anti-inflammation effect, which also inactivates glucose transporter type 4 (GLUT4) by p38 mitogen-activated protein kinase (MAPK) inhibition. Translocation of GLUT4 regulates body glucose homeostasis and muscle repair and is induced by
Chien-Min, Chen, Lian, Chiu, Hung-Chi, Chen, Chun-Yuan, Cheng, Woei-Cherng, Shyu, Chii-Wen, Chou, Cheng-You, Lu, Chung-Tien, Lin   +7 more
openaire   +2 more sources

Mulberry (Morus alba L.) Leaf Extract and 1-Deoxynojirimycin Improve Skeletal Muscle Insulin Resistance via the Activation of IRS-1/PI3K/Akt Pathway in db/db Mice

, 2022
Mulberry (Morus alba L.) leaves have been used to lower blood glucose in patients with diabetes. We evaluated the effects of mulberry leaves extract (MLE) and 1-deoxynojirimycin (1-DNJ) in improving insulin resistance through the activation of the IRS-1 ...
Park, Miey, Kang, Chae-Won, Miey Park, Chae-Won Kang, Hae-Jeung Lee, Lee, Hae-Jeung   +5 more
core   +1 more source