Results 21 to 30 of about 181,335 (186)

Dysregulation of Glucose Homeostasis Following Chronic Exogenous Administration of Leptin in Healthy Sprague-Dawley Rats [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Impaired glucose utilization is seen in chronic hyperleptinaemia associated conditions such as obesity and type 2 diabetes mellitus. It is unclear if this impaired glucose utilization is due to the effect of persistent hyperleptinaemia on
Khalil Wjidan, Effendi Ibrahim, Brinnell Caszo, Justin Gnanou, Harbindarjeet Singh   +4 more
doaj   +1 more source

Phosphatidylinositol 4-Kinase Type IIα Is Targeted Specifically to Cellugyrin-Positive Glucose Transporter 4 Vesicles [PDF]

Molecular Endocrinology, 2006
Phosphoinositides now emerge as important regulators of membrane traffic. In particular, phosphatidylinositol 4-phosphate may serve as a precursor for polyphosphorylated derivatives of phosphatidylinositol and, also, may regulate vesicular traffic by recruiting specific proteins to the membrane.
Zhao, Xu, Guanrong, Huang, Konstantin V, Kandror   +2 more
openaire   +2 more sources

Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4 [PDF]

Biochemical Journal, 1995
Translocation of the type 4 glucose transporter (GLUT4) to the cell surface from an intracellular pool is the major mechanism of insulin-stimulated glucose uptake in insulin-target cells. We developed a highly sensitive and quantitative method to detect GLUT4 immunologically on the surface of intact cells, using c-myc epitope-tagged GLUT4 (GLUT4myc ...
K, Ishii, H, Hayashi, M, Todaka, S, Kamohara, F, Kanai, H, Jinnouchi, L, Wang, Y, Ebina   +7 more
openaire   +2 more sources

Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Perturbations in myocardial substrate utilization have been proposed to contribute to the pathogenesis of cardiac dysfunction in diabetic subjects.
Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende   +10 more
doaj   +1 more source

Establishment of long-term high-fat diet and low dose streptozotocin-induced experimental type-2 diabetes mellitus model of insulin resistance and evaluation of seed extracts of Syzygium cumini [PDF]

Journal of HerbMed Pharmacology, 2021
Introduction: The principal mechanism responsible for reducing blood glucose is through insulin-stimulated glucose transport into skeletal muscle. The transporter protein that mediates this uptake is GLUT-4.
Pratibha Nadig, Meharban Asanaliyar, Kevin Manohar Salis   +2 more
doaj   +1 more source

The clinical cases of ketoacidosis in patients with 2 type diabetes treated with inhibitors of sodium-glucose co-transporter

Клинический разбор в общей медицине, 2021
The diabetic ketoacidosis (DKA) is the most frequent urgent condition in patients with diabetes mellitus which requires hospitalization and results to mortality. The most common causes of DKA are the presence of concomitant diseases in diabetic patients,
Diana Sh. Avzaletdinova , Ilmira Z. Khabibulluna, Olga Y. Ibragimova , Tatiana V. Morugova   +3 more
doaj   +1 more source

Halophila beccarii extract ameliorate glucose uptake in 3T3-L1 adipocyte cells and improves glucose homeostasis in streptozotocin-induced diabetic rats

Heliyon, 2022
The regulation of carbohydrate metabolizing enzymes is an effective way of reducing blood glucose levels and improving glycogen synthesis during the management of type 2 diabetes.
Vani Mathakala, Muni Kesavulu Muppuru, Uma Maheswari Devi Palempalli   +2 more
doaj   +1 more source

Muscle and adipose tissue insulin resistance: malady without mechanism?

Journal of Lipid Research, 2019
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically increased in incidence with modern life, suggesting that excess nutrients and obesity are major ...
Daniel J. Fazakerley, James R. Krycer, Alison L. Kearney, Samantha L. Hocking, David E. James   +4 more
doaj   +1 more source

Magnesium increases insulin-dependent glucose uptake in adipocytes

Frontiers in Endocrinology, 2022
BackgroundType 2 diabetes (T2D) is characterized by a decreased insulin sensitivity. Magnesium (Mg2+) deficiency is common in people with T2D. However, the molecular consequences of low Mg2+ levels on insulin sensitivity and glucose handling have not ...
Lynette J. Oost, Steef Kurstjens, Steef Kurstjens, Chao Ma, Chao Ma, Joost G. J. Hoenderop, Cees J. Tack, Jeroen H. F. de Baaij   +7 more
doaj   +1 more source

Insulin stimulated-glucose transporter Glut 4 is expressed in the retina. [PDF]

PLoS ONE, 2012
The vertebrate retina is a very metabolically active tissue whose energy demands are normally met through the uptake of glucose and oxygen. Glucose metabolism in this tissue relies upon adequate glucose delivery from the systemic circulation.
Gustavo Sánchez-Chávez, Ma Teresa Peña-Rangel, Juan R Riesgo-Escovar, Alejandro Martínez-Martínez, Rocío Salceda   +4 more
doaj   +1 more source