Results 151 to 160 of about 9,009 (166)

Tumor specific cytotoxicity of glucosylceramide

Cancer Chemotherapy and Pharmacology, 2007
To develop a new taxon of anti-cancer agent with lower side effect, this study described a tumor selective cytotoxicity of glucosylceramide extracted from malt feed of beer brewing waste. Interpretation of (13)C- and (1)H-NMR spectra identified the chemical structure of major component of glucosylceramide as 1-O-beta-D: -glucopyranosyl-2(2 ...
Hirosuke, Oku, Sawitree, Wongtangtintharn, Hironori, Iwasaki, Masashi, Inafuku, Masayuki, Shimatani, Takayoshi, Toda   +5 more
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Compartmentation and topology of glucosylceramide synthesis

Biochemical Society Transactions, 2000
Evidence is presented supporting a model for glucosylceramide formation on the apoplastic side of the plasma membrane in plants. Glucosylceramide synthase and sterol glucosyltransferase were both localized to the plasma membrane. Whereas sterol glucosylation was sensitive to proteolytic enzymes, ceramide glucosylation was not.
J L, Cantatore, S M, Murphy, D V, Lynch
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Improved inhibitors of glucosylceramide synthase.

Journal of biochemistry, 1992
An inhibitor of glucosylceramide (GlcCer) synthase, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their glucosphingolipids. This inhibitor has proved useful for the elucidation of the many functions of this lipid family [reviewed by Radin, N.S. & Inokuchi, J. (1991) Trends Glycosci. Glycotechnol.
A, Abe, J, Inokuchi, M, Jimbo, H, Shimeno, A, Nagamatsu, J A, Shayman, G S, Shukla, N S, Radin   +7 more
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Changes in Ceramides and Glucosylceramides in Mouse Skin and Human Epidermal Equivalents by Rice-Derived Glucosylceramide

Journal of Medicinal Food, 2012
Ceramides (Cer) and glucosylceramides (GlcCer) play an important role in moisturizing the epidermis. Dietary GlcCer has been reported to improve transepidermal water loss (TEWL). However, the effect of GlcCer on epidermal Cer and GlcCer has not been well established.
Hiroshi, Shimoda, Shuko, Terazawa, Shoketsu, Hitoe, Junji, Tanaka, Seikou, Nakamura, Hisashi, Matsuda, Masayuki, Yoshikawa   +6 more
openaire   +2 more sources

Glucosylceramide and Galactosylceramide Synthase

2006
Most mammalian glycosphingolipid formation begins with the synthesis of cerebrosides, glucosylceramide and galactosylceramide. The synthases catalyzing the formations of glucosylceramide (GlcCer) and galactosylceramide (GalCer) have been characterized at the gene and protein levels.
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Glucosylceramide modulates endolysosomal pH in Gaucher disease

Molecular Genetics and Metabolism, 2013
GlcCer accumulation causes Gaucher disease where GlcCer breakdown is inhibited due to a hereditary deficiency in glucocerebrosidase. Glycolipids are endocytosed and targeted to the Golgi apparatus in normal cells but in Gaucher disease they are mistargeted to lysosomes.
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Eliglustat tartrate, a prototypic glucosylceramide synthase inhibitor

Expert Review of Endocrinology & Metabolism, 2013
Eliglustat tartrate is a highly specific inhibitor of glucosylceramide synthase, developed for the treatment glucosylceramide-based glycosphingolipidoses. Eliglustat is in late clinical development for Gaucher disease type 1. Phase II and III clinical trials have demonstrated clinical efficacy for eliglustat as a stand-alone agent for newly diagnosed ...
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Glucosylceramide synthase: assay and properties.

Methods in enzymology, 1999
Glucosylceramide synthesis is a key step in the formation of most mammalian glycosphingolipids. The expanding number of cellular functions that may be glycosphinolipid dependent and the identification of this glucosylceramide synthase as a potential therapeutic target for several sphingolipid storage disorders necessitate the availability of a reliable
J A, Shayman, A, Abe
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Glucosylceramide lipidosis

2004
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Glucosylceramide lipidosis

2011
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