Results 21 to 30 of about 9,009 (166)

Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels [PDF]

Journal of Biological Chemistry, 2018
Sphingolipids, including sphingomyelin (SM) and glucosylceramide (GlcCer), are generated by the addition of a polar head group to ceramide (Cer). Sphingomyelin synthase 1 (SMS1) and glucosylceramide synthase (GCS) are key enzymes that catalyze the conversion of Cer to SM and GlcCer, respectively.
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Kotaro Hama, Takashi Tanikawa, Saori Oka, Tadaaki Saeki, Tatsuya Kumasaka, Takanori Koizumi, Seisuke Arai, Ikuo Wada, Kazuaki Yokoyama, Takayuki Sugiura, Atsushi Yamashita   +13 more
openaire   +2 more sources

Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease.

Journal of Lipid Research, 1996
Polycystic kidney disease (PKD) is a common genetic disease characterized by the proliferation of epithelial cells, formation of cysts, and the progression of renal deficiency.
S Chatterjee, W Y Shi, P Wilson, A Mazumdar   +3 more
doaj   +1 more source

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management. [PDF]

J Dermatol
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Sakai T.
europepmc   +2 more sources

The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase

Bioscience, Biotechnology, and Biochemistry, 2020
Abstract The accumulation of glucosylceramide (GlcCer), which is synthesized by UDP-glucose ceramide glucosyltransferase (UGCG), is associated with several diseases, including Gaucher disease and Parkinson’s disease. Since the inhibition of UGCG can be used to treat diseases caused by GlcCer accumulation, several UGCG inhibitors have ...
Yohei, Ishibashi, Makoto, Ito, Yoshio, Hirabayashi   +2 more
openaire   +2 more sources

Glucosylceramides Stimulate Mitogenesisin Aged Murine Epidermis [PDF]

Journal of Investigative Dermatology, 1998
Glucosylceramides (GlcCer) and ceramides (Cer) appear to have opposite effects on epidermal growth and differentiation. Whereas Cer inhibit mitosis and induce terminal differentiation and apoptosis in cultured keratinocytes, GlcCer is mitogenic in young murine epidermis.
Marchell, Nancy L., Uchida, Yoshikazu, Brown, Barbara E., Elias, Peter M., Holleran, Walter M.   +4 more
openaire   +2 more sources

Structural diversity and biological significance of glycosphingolipids in pathogenic and opportunistic fungi

Frontiers in Cellular and Infection Microbiology, 2014
Glycosphingolipids (GSLs) are ubiquitous membrane components and have key roles in biological systems, acting as second messengers or modulators of signal transduction by affecting several events, ranging from cell adhesion, cell growth, cell motility ...
Luciana Lopes Guimaraes, Luciana Lopes Guimaraes, Marcos Sergio Toledo, Felipe Araujo Souza Ferreira, Anita Hilda Straus, Helio K Takahashi   +5 more
doaj   +1 more source

Glucosylceramide Plays a Role in Fungal Germination, Lipid Raft Organization and Biofilm Adhesion of the Pathogenic Fungus Scedosporium aurantiacum

Journal of Fungi, 2020
Infections caused by Scedosporium species present a wide range of clinical manifestations, from superficial to disseminated, especially in immunocompromised patients.
Victor Pereira Rochetti, Rodrigo Rollin-Pinheiro, Evely Bertulino de Oliveira, Mariana Ingrid Dutra da Silva Xisto, Eliana Barreto-Bergter   +4 more
doaj   +1 more source

The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside

Acta Biochimica Polonica, 2020
The cell membrane, which is lipid-rich, is not only a simple mechanical barrier but also an important and complex component of the cell. It also communicates with the external environment. Sphingomyelin is an important class of phospholipids in the membrane that performs many functions.
Jian Gan, Su Jun Zheng, Xiao Rong Mao, Jun Feng Li   +3 more
openaire   +3 more sources

Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation

Biomolecules, 2014
The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses
Anthony S. Don, Xin Y. Lim, Timothy A. Couttas   +2 more
doaj   +1 more source

Defining the glucosylceramide population of C. elegans

Frontiers in Physiology, 2023
Glucosylceramides (GlcCer) are lipids that impact signaling pathways, serve as critical components of cellular membranes, and act as precursors for hundreds of other complex glycolipid species. Abnormal GlcCer metabolism is linked to many diseases, including cancers, diabetes, Gaucher disease, neurological disorders, and skin disorders. A key hurdle to
Mark A. Xatse, Carissa Perez Olsen
openaire   +3 more sources