Results 81 to 90 of about 2,629 (119)

Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics

Journal of Lipid Research, 2005
By using shotgun lipidomics based on the separation of lipid classes in the electrospray ion source (intrasource separation) and two-dimensional (2D) MS techniques (Han, X., and R. W. Gross. 2004.
Xianlin Han, Hua Cheng
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Epidermal sphingomyelins are precursors for selected stratum corneum ceramides

Journal of Lipid Research, 2000
Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique ω-hydroxylated Cer, that are key components of the stratum corneum (SC) intercellular lamellar membranes responsible for the epidermal permeability barrier ...
Yoshikazu Uchida, Mariko Hara, Hiroyuki Nishio, Ellen Sidransky, Shintaro Inoue, Fujio Otsuka, Akemi Suzuki, Peter M. Elias, Walter M. Holleran, Sumiko Hamanaka   +9 more
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Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors

, 2016
Glucosylceramide synthase (GCS) is an approved drug target for the treatment of Gaucher disease and is considered as a valid target for combating other human pathologies, including type 2 diabetes.
Rolf G. Boot (783479), Wilma E. Donker-Koopman (1720321), Anneke Strijland (1720312), Amar Ghisaidoobe (2183170), Herman S. Overkleeft (128584), Tom Wennekes (1479043), Richard J. B. H. N. van den Berg (2183168), Johannes M. F. G. Aerts (128594), Gijsbert A. van der Marel (1537651)   +8 more
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Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of Neurospora crassa

Frontiers in Microbiology, 2019
The membrane sphingolipid glucosylceramide (GlcCer) plays an important role in fungal fitness and adaptation to most diverse environments. Moreover, reported differences in the structure of GlcCer between fungi, plants and animals render this pathway a ...
Anna Huber, Gregor Oemer, Nermina Malanovic, Karl Lohner, Laura Kovács, Willi Salvenmoser, Johannes Zschocke, Markus A. Keller, Florentine Marx   +8 more
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Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals[S]

Journal of Lipid Research, 2017
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer.
Johanna von Gerichten, Kerstin Schlosser, Dominic Lamprecht, Ivan Morace, Matthias Eckhardt, Dagmar Wachten, Richard Jennemann, Hermann-Josef Gröne, Matthias Mack, Roger Sandhoff   +9 more
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Lipophilic iminosugars : synthesis and evaluation as inhibitors of glucosylceramide metabolism [PDF]

, 2008
The study described in this thesis was conducted with the aim of developing lipophilic iminosugars as selective inhibitors for glucosylceramide synthase, glucocerbrosidase and _-glucosidase 2 that are enzymes involved in glucosylceramide metabolism.
Wennekes, T.
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Image_5_CgGCS, Encoding a Glucosylceramide Synthase, Is Required for Growth, Conidiation and Pathogenicity in Colletotrichum gloeosporioides.TIF

, 2019
Fungal glucosylceramide plays important role in cell division, hyphal formation and growth, spore germination and the modulation of virulence and has recently been considered as target for small molecule inhibitors. In this study, we characterized CgGCS,
Chunyu Li (437902), Bin Li (39349), Yimei Huang (5279138), Ganjun Yi (220313), Guiming Deng (437904), Qiaosong Yang (220291), Tongxin Dou (6716630), Chunhua Hu (437906), Jian Yin (64657), Fangcheng Bi (3402446), Tao Dong (15551), Ou Sheng (437907), Huijun Gao (313518)   +12 more
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Beta-glucosidase 2 knockout mice with increased glucosylceramide show impaired liver regeneration

, 2012
BACKGROUND AND AIMS: Glycolipids have been shown to serve specialized functions in cell signalling, proliferation and differentiation processes, which are all important during liver regeneration. We previously generated beta-glucosidase 2 (GBA2) knockout
Rogler, Gerhard, Gonzalez-Carmona, Maria A, Vogt, Annabelle, Lammert, Frank, Sandhoff, Roger, Yildiz, Yildiz, Tacke, Frank, Weber, Susanne, Canbay, Ali E, Gonzalez-Carmona, Maria A., Canbay, Ali E., Sauerbruch, Tilman   +11 more
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Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans

Journal of Lipid Research
Multiple isozymes are encoded in the Caenorhabditis elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase liquid
Hui Luo, Xue Zhao, Zi-Dan Wang, Gang Wu, Yu Xia, Meng-Qiu Dong, Yan Ma   +6 more
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Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation [PDF]

, 2017
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars. In the studies described, 1-deoxynojirimycin (DNJ), and its known N-alkylated derivatives, served as starting points. DNJ
Liu, B.
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