Results 61 to 70 of about 9,362 (180)

The Enigmatic Role of GBA2 in Controlling Locomotor Function

Frontiers in Molecular Neuroscience, 2017
The non-lysosomal glucosylceramidase GBA2 catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Loss of GBA2 function results in accumulation of glucosylceramide.
Marina A. Woeste, Dagmar Wachten, Dagmar Wachten   +2 more
doaj   +1 more source

Obesity Modifies Sphingolipid Signatures in Childhood Asthma

Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh, Alaa Abdelhamid, Ahmed Arabi, Yaman Al‐Haneedi, Shana Jacob, Giridhara Rathnaiah Babu, Stefan Worgall, Ibrahim Janahi   +7 more
wiley   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Glucosylceramide in the nervous system - A mini-review [PDF]

Neurochemical Research, 1994
A reviewer of this manuscript has recommended that I warn the reader that the hypotheses offered here do not have enough experimental support to make them widely accepted.
openaire   +3 more sources

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, Volume 4, Issue 2, June 2026.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride

Journal of Lipid Research, 2003
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral ...
Jacques Bodennec, Selena Trajkovic-Bodennec, Anthony H. Futerman   +2 more
doaj   +1 more source

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

eLife, 2019
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Matthijs Kol, Ben Williams, Henry Toombs-Ruane, Henri G Franquelim, Sergei Korneev, Christian Schroeer, Petra Schwille, Dirk Trauner, Joost CM Holthuis, James A Frank   +9 more
doaj   +1 more source

Synthesis and Biological Properties of Fungal Glucosylceramide

PLoS Pathogens, 2014
Sphingolipids have recently emerged as key regulators of pathogenicity in a variety of fungi. Glucosylceramide is a sphingolipid important for fungal cell division, alkaline tolerance, hyphal formation, and spore germination and, thus, for the regulation of fungal virulence. Present in many fungi, including yeasts, molds, and in dimorphic fungi, fungal
Maurizio Del Poeta, Leonardo Nimrichter, Marcio L Rodrigues, Chiara Luberto   +3 more
openaire   +4 more sources

Drug resistance-associated changes in sphingolipids and ABC transporters occur in different regions of membrane domains

Journal of Lipid Research, 2005
We have recently shown that two ATP binding cassette (ABC) transporters are enriched in Lubrol-resistant noncaveolar membrane domains in multidrug-resistant human cancer cells [Hinrichs, J. W. J., K. Klappe, I. Hummel, and J. W. Kok. 2004.
John W.J. Hinrichs, Karin Klappe, Manon van Riezen, Jan W. Kok   +3 more
doaj   +1 more source

Avaliação de dois anos de tratamento da doença de Gaucher tipo 1 com terapia de reposição enzimática em pacientes do estado de São Paulo, Brasil Evaluation of two years of treatment with enzyme replacement therapy in type 1 Gaucher disease patients of São Paulo State, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2008
A doença de Gaucher tipo 1 é a doença de depósito lisossômico mais freqüente. De herança autossômica recessiva, é caracterizada pela deficiência da atividade da enzima glicocerebrosidase e o acúmulo patológico de seu substrato, a glicosilceramida, nas ...
Elisa A. P. Sobreira, Paula Bruniera
doaj   +1 more source