Results 91 to 100 of about 57,722 (254)

A QSP Model of Valproic Acid Toxicity in Pediatric and Adult Populations: Implications for Formulation Selection and L‐Carnitine Supplementation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
Schematic workflow of the QSP model development and application. The study builds upon an initial adult male model structure (top left) by integrating reported data on age‐related changes in elimination pathways (top right). This allowed for the extension of the QSP model to pediatric and female populations (bottom right), which was then used to ...
Alejandra Schiavo, Cecilia Maldonado, Marta Vázquez, Pietro Fagiolino, Inaki F. Trocóniz, Manuel Ibarra   +5 more
wiley   +1 more source

Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent

Pharmaceutics, 2018
The hepatic uridine 5′-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can ...
Steffen G. Oeser, Jon-Paul Bingham, Abby C. Collier   +2 more
doaj   +1 more source

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source

Species Differences in Ezetimibe Glucuronidation

Metabolites
Background: Peclinical and clinical studies have revealed that ezetimibe, an approved cholesterol-absorption inhibitor, is rapidly and extensively metabolized to a more potent metabolite, ezetimibe glucuronide.
Shalom Emmanuel, Eric A. Asare, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +1 more source

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]

The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm, Beresford, Borchard, Kobayashi, Mahmoudian, Mahmoudian, Mohri, Moldeus, Ramsch, Roden, Scherling, Scherling, Scherling, Stopher, Teramura, Van Zwieten   +15 more
core   +1 more source

Significance of dietary antioxidants for health [PDF]

, 2011
Since evidence became available that free radicals were involved in mechanisms for the development of major diseases, including cardiovascular disease and cancer, there has been considerable research into the properties of natural dietary antioxidants ...
Gordon, Mike
core   +3 more sources

Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism [PDF]

, 2011
peer reviewedaudience: researcher, professional, student, popularization, otherThe current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass.
Adams, Adrian Covaci, Alin C. Dirtu, Blanton, Boas, Brouwer, Brouwer, Brouwer, Brown, Brown, Capen, Coimbra, Collins, Collins, Darnerud, Eales, Eales, Fowles, Hallgren, Hallgren, Hood, Inui, Ishihara, Iwanowicz, Joseph G. Schnitzler, Klaassen, Klaren, Klaren, Krishna Das, Leatherland, Leatherland, Leatherland, Letcher, Loizeau, Loizeau, Morse, Morse, Niko Celis, Peter H.M. Klaren, Pickett, Power, Richardson, Ronny Blust, Safe, Schnitzler, Schnitzler, Schuur, Shiao, Spear, Theodorakis, Van der Geyten, van der Heide, Visser, Wade, Yamano, Yoshiura, Zoeller   +56 more
core   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry in Studies of Neurotransmitters and Their Metabolites in the Brain [PDF]

, 2009
Neurotransmitters transfer chemically the electrical impulse from one neuron to another in the brain. The concentration of neurotransmitters in many neurological disorders is altered.
Uutela, Päivi
core  

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation

Drug Delivery, 2017
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA).
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou   +4 more
doaj   +1 more source

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing

Cell Reports, 2016
Maintenance of cellular homeostasis and xenobiotic detoxification is mediated by 19 human UDP-glucuronosyltransferase enzymes (UGTs) encoded by ten genes that comprise the glucuronidation pathway.
Michèle Rouleau, Alan Tourancheau, Camille Girard-Bock, Lyne Villeneuve, Jonathan Vaucher, Anne-Marie Duperré, Yannick Audet-Delage, Isabelle Gilbert, Ion Popa, Arnaud Droit, Chantal Guillemette   +10 more
doaj   +1 more source