Results 101 to 110 of about 56,016 (216)

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants [PDF]

, 2015
Purpose: Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing.
Allegaert, K.M. (Karel), Danhof, M. (Meindert), Hoon, J.N. de, Knibbe, C.A.J. (Catherijne), Krekels, E.H.J. (Elke), Tibboel, D. (Dick), Van Ham, S. (Saskia)   +6 more
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Glucuronide metabolism in plants. 3. Triterpene glucuronides [PDF]

Biochemical Journal, 1956
C A, MARSH, G A, LEVVY
openaire   +2 more sources

The Effect of Uridine Diphosphate‐Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites

Clinical and Translational Science
Ecopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 ...
Virginia D. Schmith, Danielle Graden, Joy Schleyer, Stephen P. Wanaski   +3 more
doaj   +1 more source

Pharmacokinetic Variability of Mycophenolic Acid in Pediatric and Adult Patients with Hematopoietic Stem Cell Transplantation [PDF]

, 2016
The aim of this study was to evaluate the pharmacokinetic variations of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in both pediatric and adult patients following hematopoietic stem cell transplantation (HSCT).
Chow, Diana S-L., Renbarger, Jamie L., Zhang, Daping   +2 more
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Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells.

PLoS ONE, 2016
This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang, Zhongqiu Liu   +10 more
doaj   +1 more source

Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism [PDF]

, 2011
peer reviewedaudience: researcher, professional, student, popularization, otherThe current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass.
Adams, Adrian Covaci, Alin C. Dirtu, Blanton, Boas, Brouwer, Brouwer, Brouwer, Brown, Brown, Capen, Coimbra, Collins, Collins, Darnerud, Eales, Eales, Fowles, Hallgren, Hallgren, Hood, Inui, Ishihara, Iwanowicz, Joseph G. Schnitzler, Klaassen, Klaren, Klaren, Krishna Das, Leatherland, Leatherland, Leatherland, Letcher, Loizeau, Loizeau, Morse, Morse, Niko Celis, Peter H.M. Klaren, Pickett, Power, Richardson, Ronny Blust, Safe, Schnitzler, Schnitzler, Schuur, Shiao, Spear, Theodorakis, Van der Geyten, van der Heide, Visser, Wade, Yamano, Yoshiura, Zoeller   +56 more
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Synthesis of cortol 3-glucuronides and cortolone 3-glucuronides.

Chemical and Pharmaceutical Bulletin, 1984
The synthesis of the 3-glucuronides of 20α-cortolone and their 20β-epimers is described. The cortol 20, 21-diacetates (3, 10) and cortolone 20, 21-diacetates (6, 12) were the key intermediates. Sodium borohydride reduction of the carbonyl group at C-20 in 21-acetoxy-3α, 11β, 17α-trihydroxy-5β-pregnan-20-one 3-tert-butyldimethylsilyl ether (1) or its 11-
H, Hosoda, H, Yokohama, T, Nambara
openaire   +3 more sources

Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis1

Journal of Lipid Research, 2001
Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients
Hanns-Ulrich Marschall, Ulrika Broomé, Curt Einarsson, Gunvor Alvelius, Hans Günther Thomas, Siegfried Matern   +5 more
doaj   +1 more source

Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry

Toxins, 2019
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to
Irina Slobodchikova, Reajean Sivakumar, Md Samiur Rahman, Dajana Vuckovic   +3 more
doaj   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry in Studies of Neurotransmitters and Their Metabolites in the Brain [PDF]

, 2009
Neurotransmitters transfer chemically the electrical impulse from one neuron to another in the brain. The concentration of neurotransmitters in many neurological disorders is altered.
Uutela, Päivi
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