Glucuronide metabolism in plants. 3. Triterpene glucuronides [PDF]
Biochemical Journal, 1956 C A, MARSH, G A, LEVVY
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Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin [PDF]
, 2018 Seiya Tanaka +4 more
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Synthesis of cortol 3-glucuronides and cortolone 3-glucuronides.
Chemical and Pharmaceutical Bulletin, 1984 The synthesis of the 3-glucuronides of 20α-cortolone and their 20β-epimers is described. The cortol 20, 21-diacetates (3, 10) and cortolone 20, 21-diacetates (6, 12) were the key intermediates. Sodium borohydride reduction of the carbonyl group at C-20 in 21-acetoxy-3α, 11β, 17α-trihydroxy-5β-pregnan-20-one 3-tert-butyldimethylsilyl ether (1) or its 11-
H, Hosoda, H, Yokohama, T, Nambara
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Control of glucuronidation during hypoxia. Limitation by UDP-glucose pyrophosphorylase [PDF]
, 1984 Tak Yee Aw, Dean P. Jones
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Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis1
Journal of Lipid Research, 2001 Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients
Hanns-Ulrich Marschall +5 more
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Toxins, 2019 Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to
Irina Slobodchikova +3 more
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Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants [PDF]
, 2006 Dongxiao Sun +5 more
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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) [PDF]
, 2001 CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug.
Alphen, R.J. (Robbert) van +6 more
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UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes [PDF]
, 2015 Lijun Zhu +9 more
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