Results 101 to 110 of about 25,845 (281)

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 497-509, August 2025.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 378-385, August 2025.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan   +4 more
wiley   +1 more source

Glucuronide metabolism in plants. 3. Triterpene glucuronides [PDF]

Biochemical Journal, 1956
C. A. Marsh, G. A. Levvy
openaire   +3 more sources

Bioactive Compounds, Their Mechanisms of Action, and Cardioprotective Effects of Pomegranate (Punica granatum): A Comprehensive Review

eFood, Volume 6, Issue 4, August 2025.
Pomegranate parts (arils, peel, and flower) contain antioxidants, polyphenols, and flavonoids. These bioactives reduce inflammation, improve endothelial function, and modulate lipids. Regular intake lowers blood pressure, LDL, and atherosclerotic plaque while increasing HDL.
Esha Saeed, Farah Javed, Zoya Rana, Rashida Perveen, Iftikhar Younis Mallhi, Izza Amjad, Quratulain Maqsood, Nauman Ali Chaudhary, Saleha Binte Tahir, Arooj Fatima, Noor Fatima Rasheed, Esther Ugo Alum   +11 more
wiley   +1 more source

HALOTHANE ANESTHESIA HAS NO EFFECT ON THE M-3-GLUCURONIDATION OF MORPHINE [PDF]

, 1987
W. J. Merrell, Andrew J. Wood, Edwin K. Jackson, Sheila Shay, Margaret Wood   +4 more
openalex   +1 more source

The Beneficial Effects of Berberine on Brain Functions in Age‐Related Neurological Disorders: From Molecular Signaling to Treatment

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The positive influence of berberine on the nervous system can be attributed to its diverse effects on multiple targets. The effects of berberine include its antioxidant, anti‐apoptotic, anti‐necroptotic, and anti‐inflammatory properties, as well as its ability to induce autophagy.
Xiaolan Wang, Ruiliang Hou, Zhihao Chen, Xiaoyang Wang, Melika Malek, Haoyu Wang   +5 more
wiley   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, Volume 65, Issue 8, Page 1026-1038, August 2025.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Cannabinoid-Induced Stereoselective Inhibition of R-S-Oxazepam Glucuronidation: Cannabinoid–Oxazepam Drug Interactions

Pharmaceutics
Benzodiazepines (BZDs) such as oxazepam are commonly prescribed depressant drugs known for their anxiolytic, hypnotic, muscle relaxant, and anticonvulsant effects and are frequently used in conjunction with other illicit drugs including cannabis ...
Keti Bardhi, Shelby Coates, Gang Chen, Philip Lazarus   +3 more
doaj   +1 more source

Interindividual variability in the glucuronidation and sulphation of ethinyloestradiol in human liver. [PDF]

, 1991
A. Temellini, L. Giuliani, G. M. Pacifici   +2 more
openalex   +1 more source

Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3‐L1 Adipocytes

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Metabolites derived from wild blueberry (poly)phenols, such as syringic (SA), vanillic (VA), and isoferulic acids (IA), can modulate lipid metabolism and oxidative stress markers in mature 3T3‐L1 adipocytes treated with free fatty acids (FFAs; oleic/palmitic acid, 750 µM, 2:1 ratio).
Samuele Venturi, Marco Rendine, Mirko Marino, Dorothy Klimis‐Zacas, Patrizia Riso, Cristian Del Bo'   +5 more
wiley   +1 more source