Results 81 to 90 of about 25,845 (281)

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.

Carcinogenesis, 2014
Nicotine metabolism influences smoking behavior and differences in metabolism probably contribute to ethnic variability in lung cancer risk. We report here on the proportion of nicotine metabolism by cytochrome P450 2A6-catalyzed C-oxidation, UDP ...
S. Murphy, S. L. Park, Elizabeth F Thompson, L. Wilkens, Yesha M Patel, D. Stram, L. Le Marchand   +6 more
semanticscholar   +1 more source

Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Therapeutic drug monitoring for astronauts faces limitations in conventional blood sampling and sample management onboard the international space station. Here, we explore the feasibility of dried blood spot (DBS) collection during parabolic flights (PF) to overcome these constraints.
Audrey Derobertmasure, Li Shean Toh, Céline Verstuyft, Srboljub Lukic, Christelle De Sousa Carvalho, Raphaël Couronné, Marie Beauvalet, Stéphanie Chhun, Pierre Boutouyrie   +8 more
wiley   +1 more source

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation

Drug Delivery, 2017
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA).
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou   +4 more
doaj   +1 more source

Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences.

Drug Metabolism and Pharmacokinetics, 2014
Resveratrol, a natural polyphenol found in grapes, berries and other plants, has been proposed as an ideal chemopreventative agent due to its plethora of health promoting activities.
R. Dellinger, Angela Garcia, F. Meyskens
semanticscholar   +1 more source

Chemical profiling and characterisation of anthraquinone‐based polyphenols as biocolourants from Cortinarius semisanguineus

Coloration Technology, EarlyView.
Abstract Anthraquinone dyes are known for their significant colour (brightness of shade in the red, blue and green areas) and light fastness properties compared with other synthetic dyes (such as azo‐based dyes). However, challenging multi‐step synthesis of anthraquinones and limited access to fewer substituents result in insufficient reactivity ...
Arvind Negi, Peppi Toukola, Riikka Räisänen   +2 more
wiley   +1 more source

Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry

Toxins, 2019
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to
Irina Slobodchikova, Reajean Sivakumar, Md Samiur Rahman, Dajana Vuckovic   +3 more
doaj   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Pharmaceutics, 2017
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Yuejian Liu, Michael W. H. Coughtrie
doaj   +1 more source

Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa

Plant Biotechnology Journal, EarlyView.
Summary Saponins constitute a class of characteristic compounds within quinoa grains. In this study, metabolomic analysis identified 20 triterpene saponins, the majority of which were exclusively localized within the pericarp. Furthermore, three crucial glycosyltransferases were identified in quinoa.
Yiming Zhang, Peng Zhu, Long Wu, Zhaohui Li, Yongshun Huang, Mingyu Wang, Kaiying Gu, Peng Wang, Jun Li, Huihua Wan, Hailong Zhang, Jianghua Chen, Ruikun He, Wei Sun, Lixin Li   +14 more
wiley   +1 more source