Results 81 to 90 of about 57,722 (254)
Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway [PDF]
, 2019 Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways.
Bellissimo, L +6 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.ABSTRACT Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives.
Nádia Aguiar Portela Pinheiro +11 more
wiley +1 more source
Molecules, 2019 GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear.
Han Xing +12 more
doaj +1 more source
Gas Chromatography of Glucuronides.
Chemical and Pharmaceutical Bulletin, 1967 The applicability of gas chromatography to the analysis of various types of glucuronides including ether-, ester-, N-and S-glucuronides was studied by converting them to acetyl, methyl and trimethylsilyl derivatives.
T, Imanari, Z, Tamura
openaire +3 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Vildagliptin (VDG) is a dipeptidyl‐peptidase‐4 (DPP‐4) inhibitor used for type 2 diabetes (T2DM) treatment. Viewing to improve VDG treatment, a population pharmacokinetic (popPK) model was built to describe drug plasma, free liver and muscle concentrations determined by microdialysis in healthy and diabetic animals following 50 mg/kg i.v ...
Bruna Bernar Dias +2 more
wiley +1 more source
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
Pharmaceutics, 2018 Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously.
Pil Joung Cho +7 more
doaj +1 more source
Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats [PDF]
, 2017 The extent of bioactivation of the herbal constituent estragole to its ultimate carcinogenic metabolite 1′-sulfooxyestragole depends on the relative levels of bioactivation and detoxification pathways.
Bladeren, Peter J. van +8 more
core
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids [PDF]
, 2016 At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in ...
Cassidy, Aedin, Minihane, Anne-Marie
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu +6 more
wiley +1 more source
MoleculesAE90015 is a highly specific and effective negative allosteric modulator (NAM) for the human mGlu5 receptor, showing significant promise for treating Parkinson’s disease.
Zhiyang Zack Zou +3 more
doaj +1 more source