Results 211 to 220 of about 38,797 (256)

Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles

Diabetes, 1997
The GLUT4 system in muscle and fat cells plays an important role in whole-body glucose homeostasis. Insulin stimulates the translocation of GLUT4 from an intracellular storage compartment to the cell surface. The nature of this compartment remains largely unknown.
Rea S., James D.E.
openaire   +5 more sources

Muscle GLUT4 in cirrhosis

Journal of Hepatology, 2007
The insulin-dependent glucose transporter GLUT4 mediates 50-80% of whole body glucose uptake, but its relation to the frequent glucose intolerance in patients with liver cirrhosis is unknown.Thirty patients and seven healthy controls underwent a 2-h oral glucose tolerance test and later a muscle biopsy.
Holland-Fischer, Peter, Andersen, Per Heden, Lund, Sten, Pedersen, Steen Bønnelykke, Vinter-Jensen, Lars, Nielsen, Michael F, Kaal, Andreas, Dall, Rolf, Schmitz, Ole, Vilstrup, Hendrik   +9 more
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Regulated transport of the glucose transporter GLUT4

Nature Reviews Molecular Cell Biology, 2002
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes--the ...
Nia J Bryant, Roland Govers, David E James   +2 more
exaly   +4 more sources

SNARES for GLUT4 - mechanisms directing vesicular trafficking of GLUT4

Frontiers in Bioscience, 2003
Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear.
Julian, Grusovin, S Lance, Macaulay
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Peptide rescues GLUT4 recruitment, but not GLUT4 activation, in insulin resistance

Biochemical and Biophysical Research Communications, 2007
Insulin-stimulated GLUT4 recruitment to the plasma membrane is impaired in insulin resistance. We recently reported that a cell permeable phosphoinositide-binding peptide induces GLUT4 recruitment as potently as insulin, but does not activate GLUT4 to initiate glucose uptake.
Makoto, Funaki, Kate, Benincasa, Paramjeet K, Randhawa   +2 more
openaire   +2 more sources

Building GLUT4 Vesicles: CHC22 Clathrin’s Human Touch [PDF]

Trends in Cell Biology, 2020
Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent
Gwyn W Gould, Frances M Brodsky, Nia J Bryant   +2 more
exaly   +1 more source

Hepatic response to restoration of GLUT4 in skeletal muscle of GLUT4 null mice

American Journal of Physiology-Endocrinology and Metabolism, 2007
Expression of GLUT4 in fast-twitch skeletal muscle fibers of GLUT4 null mice (G4-MO) normalized glucose uptake in muscle and restored peripheral insulin sensitivity. GLUT4 null mice exhibit altered carbohydrate and lipid metabolism in liver and skeletal muscle.
Mollie, Ranalletta, Xiu Quan, Du, Yoshinori, Seki, Alan S, Glenn, Michael, Kruse, Ariana, Fiallo, Irma, Estrada, Tsu-Shuen, Tsao, Antine E, Stenbit, Ellen B, Katz, Maureen J, Charron   +10 more
openaire   +2 more sources

Mapping Insulin/GLUT4 Circuitry

Traffic, 2011
One of the most important metabolic actions of insulin is catalysing glucose uptake into skeletal muscle and adipose tissue. This is accomplished via activation of the phosphatidylinositol‐3‐kinase/Akt signalling pathway and subsequent translocation of GLUT4 from intracellular storage vesicles to the plasma membrane.
Alexander F, Rowland, Daniel J, Fazakerley, David E, James   +2 more
openaire   +2 more sources

Isolation of GLUT4 Storage Vesicles

Current Protocols in Cell Biology, 2006
AbstractThe immunoisolation of GLUT4‐containing vesicles from adipocytes is described in this unit. The methods involve homogenization of cells followed by differential centrifugation to provide the intracellular membranes that contain GLUT4. Subsequently, an immobilized monoclonal antibody is used for the isolation of vesicles of very high purity. The
Konstantin V, Kandror, Paul F, Pilch
openaire   +2 more sources