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Posttranslational Modifications of GLUT4 Affect Its Subcellular Localization and Translocation [PDF]
International Journal of Molecular Sciences, 2013 The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Jessica B A Sadler +2 more
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Autophagy and GLUT4: The missing pieces
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2018Autophagy is a process devoted to degrade and recycle cellular components inside mammalian cells through lysosomal system. It plays a main function in the pathophysiology of several diseases. In type 2 diabetes, works demonstrated the dual functions of autophagy in diabetes biology.
Safa Abdelgadir Mohamed Elhassan +3 more
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A Long Search for Glut4 Activation
Science's STKE, 2003Insulin stimulates glucose transport in its target cells by translocation of the glucose transporter isoform 4 (Glut4) from an intracellular storage pool to the plasma membrane. A large body of evidence indicates that activity of Glut4 at the plasma membrane may vary.
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A robust assay measuring GLUT4 translocation in rat myoblasts overexpressing GLUT4-myc and AS160_v2
Analytical Biochemistry, 2010Muscle and fat cells translocate GLUT4 (glucose transporter 4) to the plasma membrane when stimulated by insulin. Usually, this event is measured in differentiated adipocytes, myotubes, or cell lines overexpressing tagged GLUT4 by immunostaining. However, measurement of the translocation in differentiated adipocytes or myotubes or GLUT4 overexpressing ...
Daniela, Baus +5 more
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Science, 2009
A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane.
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A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane.
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Biochemical Society Transactions, 1999
By using glycerol density gradients of post-plasma membrane supernatants from rat adipocytes, we have been able to separate the compartment containing GLUT4 from that containing transferrin receptors. The major pool of GLUT4 (≈ 80%) is localised to dense fractions, which also contain VAMP2, while the remainder is in lighter fractions, some of which ...
Alison K. Gillingham +4 more
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By using glycerol density gradients of post-plasma membrane supernatants from rat adipocytes, we have been able to separate the compartment containing GLUT4 from that containing transferrin receptors. The major pool of GLUT4 (≈ 80%) is localised to dense fractions, which also contain VAMP2, while the remainder is in lighter fractions, some of which ...
Alison K. Gillingham +4 more
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Molecular mechanisms of GLUT4 regulation in adipocytes
Diabetes & Metabolism, 2014Insulin resistance is strongly linked to type 2 diabetes and associated with a reduced uptake of glucose by muscle and adipose tissue. The transporter that is responsible for this uptake and whose function is disturbed in insulin resistance and type 2 diabetes is GLUT4. In the non-stimulated state, GLUT4 is efficiently sequestered intracellularly. This
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