Results 1 to 10 of about 808,551 (332)
Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease
Frontiers in Neuroscience, 2020 Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang +10 more
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Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?
Frontiers in Neuroscience, 2015 Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
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Cells, 2019 Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa Mahmoud +3 more
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Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan +3 more
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Biomolecules, 2016 Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
Nature Communications, 2021 Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park +10 more
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Accuracy in readout of glutamate concentrations by neuronal cells [PDF]
The European Physical Journal E, 46(4), 30 (2023), 2023 Glutamate and glycine are important neurotransmitters in the brain. An action potential prop- agating in the terminal of a presynatic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post synaptic neuron.
arxiv +1 more source
Illuminating Relationships Between the Pre- and Post-synapse
Frontiers in Neural Circuits, 2020 Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities.
Thomas M. Sanderson +4 more
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Glutamate and reinstatement [PDF]
Current Opinion in Pharmacology, 2009 The importance of glutamate in the reinstatement of cocaine-seeking behavior has been established. New molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of CB1 receptor stimulation to reduce basal glutamate levels and the involvement of the GluR1 receptor subunit in
Lori A. Knackstedt, Peter W. Kalivas
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Nature Communications, 2020 Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang +11 more
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