Results 1 to 10 of about 898,814 (388)
Cells, 2019 Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa Mahmoud +3 more
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
Nature Communications, 2021 Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park +10 more
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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Pharmacological Reviews, 2021 Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs).
K. Hansen +18 more
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Glutamate and reinstatement [PDF]
Current Opinion in Pharmacology, 2009 The importance of glutamate in the reinstatement of cocaine-seeking behavior has been established. New molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of CB1 receptor stimulation to reduce basal glutamate levels and the involvement of the GluR1 receptor subunit in
Lori A, Knackstedt, Peter W, Kalivas
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Illuminating Relationships Between the Pre- and Post-synapse
Frontiers in Neural Circuits, 2020 Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities.
Thomas M. Sanderson +4 more
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Бюллетень сибирской медицины, 2022 Aim. To compare the frequency of genotypes for polymorphic variants of GRIN2A and GRIN2B genes in patients with schizophrenia and addictive behavior (alcohol / tobacco abuse) and in patients with schizophrenia without addictive behavior in the Slavic ...
V. V. Tiguntsev +5 more
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British Journal of Pharmacology, 2006 Glutamatergic synaptic transmission in the mammalian central nervous system was slowly established over a period of some 20 years, dating from the 1950s. Realisation that glutamate and like amino acids (collectively known as excitatory amino acids (EAA)) mediated their excitatory actionsviamultiple receptors preceded establishment of these receptors as
Watkins, JC, Jane, DE
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Nature Communications, 2020 Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang +11 more
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Does Prefrontal Glutamate Index Cognitive Changes in Parkinson’s Disease?
Frontiers in Human Neuroscience, 2022 IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease (PD). A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia.
Isabelle Buard +10 more
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Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy
Frontiers in Neurology, 2020 Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate ...
Allison R. Peterson, Devin K. Binder
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