Results 1 to 10 of about 324,762 (100)
Glutamate and reinstatement [PDF]
Current Opinion in Pharmacology, 2009 The importance of glutamate in the reinstatement of cocaine-seeking behavior has been established. New molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of CB1 receptor stimulation to reduce basal glutamate levels and the involvement of the GluR1 receptor subunit in
Lori A. Knackstedt, Peter W. Kalivas
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British Journal of Pharmacology, 2006 Glutamatergic synaptic transmission in the mammalian central nervous system was slowly established over a period of some 20 years, dating from the 1950s. Realisation that glutamate and like amino acids (collectively known as excitatory amino acids (EAA)) mediated their excitatory actionsviamultiple receptors preceded establishment of these receptors as
Watkins, JC, Jane, DE
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Production of
Bioscience, Biotechnology, and Biochemistry, 1999 We studied production of D-glutamate from L-glutamate using a bioreactor consisting of two columns of sequentially connected immobilized glutamate racemase (EC 5.1.1.3, from Bacillus subtilis IFO 3336) and L-glutamate oxidase (EC 1.4.3.11, from Streptomyces sp.
Tadao Oikawa +5 more
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Energetics of Glutamate Binding to an Ionotropic Glutamate Receptor [PDF]
The Journal of Physical Chemistry B, 2017 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are responsible for the majority of excitatory transmission at the synaptic cleft. Mechanically speaking, agonist binding to the ligand binding domain (LBD) activates the receptor by triggering a conformational change that is transmitted to the transmembrane region, opening the ...
Alvin Yu +3 more
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Glutamate, Glutamate Receptors, and Downstream Signaling Pathways [PDF]
International Journal of Biological Sciences, 2013 Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways. Glutamate signaling activates a family of receptors consisting of metabotropic glutamate receptors (
Stacey S. Willard, Shahriar Koochekpour
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The Journal of Nutrition, 2000 Epileptic syndromes have very diverse primary causes, which may be genetic, developmental or acquired. In rodent models, altering glutamate receptor or glutamate transporter expression by knockout or knockdown procedures can induce or suppress epileptic seizures.
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Glutamate Taste: Discrimination between the Tastes of Glutamate Agonists and Monosodium Glutamate in Rats [PDF]
Chemical Senses, 2004 Taste aversion studies have demonstrated that rats conditioned to avoid monosodium glutamate (MSG) with amiloride added to reduce the intensity of the sodium component of MSG taste, generalize this aversion to aspartic acid and to L-AP4, but not to ionotropic glutamate receptor agonists.
Delay, Eugene R. +3 more
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Glutamate transporter control of ambient glutamate levels
Neurochemistry International, 2014 Accurate knowledge of the ambient extracellular glutamate concentration in brain is required for understanding its potential impacts on tonic and phasic receptor signaling. Estimates of ambient glutamate based on microdialysis measurements are generally in the range of ∼2-10μM, approximately 100-fold higher than estimates based on electrophysiological ...
Weinan Sun +3 more
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Cortical glutamate in migraine [PDF]
Brain, 2017 Cortical hyperexcitability due to enhanced glutamatergic activity has been implicated in migraine pathophysiology but direct evidence is lacking. Here we assessed glutamate levels and intracellular mobility of glutamate in the visual cortex of migraineurs in-between attacks.
Mark C. Kruit +9 more
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