Results 1 to 10 of about 585,844 (339)

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +3 more sources

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

Cells, 2019
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa Mahmoud, Marjan Gharagozloo, Camille Simard, Denis Gris   +3 more
doaj   +2 more sources

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
doaj   +1 more source

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Pharmacological Reviews, 2021
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs).
K. Hansen, L. Wollmuth, D. Bowie, Hiro Furukawa, F. Menniti, A. Sobolevsky, G. Swanson, Sharon A. Swanger, I. Greger, T. Nakagawa, C. McBain, V. Jayaraman, C. Low, M. Dell’Acqua, J. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan, S. Traynelis   +18 more
semanticscholar   +1 more source

Illuminating Relationships Between the Pre- and Post-synapse

Frontiers in Neural Circuits, 2020
Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities.
Thomas M. Sanderson, John Georgiou, Graham L. Collingridge, Graham L. Collingridge, Graham L. Collingridge   +4 more
doaj   +1 more source

Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents

Frontiers in Psychiatry, 2021
Animal models of stress and related conditions, including depression, have shown that elevated peripheral levels of inflammatory cytokines have downstream consequences on glutamate (Glu) in the brain. Although studies in human adults with depression have
Tiffany C. Ho, Giana I. Teresi, Jillian R. Segarra, Amar Ojha, Johanna C. Walker, Meng Gu, Daniel M. Spielman, Matthew D. Sacchet, Fei Jiang, Yael Rosenberg-Hasson, Holden Maecker, Ian H. Gotlib   +11 more
doaj   +1 more source

Glutamate Scavenging as a Neuroreparative Strategy in Ischemic Stroke

Frontiers in Pharmacology, 2022
Stroke is the second highest reason of death in the world and the leading cause of disability. The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of blood vessels. Therapeutic applications for ischemic stroke include
Oykum Kaplan-Arabaci, Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik, Devrim Gozuacik, Devrim Gozuacik   +6 more
doaj   +1 more source

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Nature Communications, 2020
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa   +11 more
doaj   +1 more source

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways [PDF]

International Journal of Biological Sciences, 2013
Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways. Glutamate signaling activates a family of receptors consisting of metabotropic glutamate receptors (
Willard, Stacey S., Koochekpour, Shahriar   +1 more
openaire   +2 more sources

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Frontiers in Molecular Neuroscience, 2022
Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li   +5 more
doaj   +1 more source