Results 1 to 10 of about 537,331 (283)

Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease

Frontiers in Neuroscience, 2020
Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Shaogang Qu
exaly   +4 more sources

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

Frontiers in Neuroscience, 2015
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Jan Lewerenz, Pamela Maher
exaly   +4 more sources

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +4 more sources

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
doaj   +1 more source

Accuracy in readout of glutamate concentrations by neuronal cells [PDF]

The European Physical Journal E, 46(4), 30 (2023), 2023
Glutamate and glycine are important neurotransmitters in the brain. An action potential prop- agating in the terminal of a presynatic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post synaptic neuron.
arxiv   +1 more source

Illuminating Relationships Between the Pre- and Post-synapse

Frontiers in Neural Circuits, 2020
Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities.
Thomas M. Sanderson, John Georgiou, Graham L. Collingridge, Graham L. Collingridge, Graham L. Collingridge   +4 more
doaj   +1 more source

Glutamate and reinstatement [PDF]

Current Opinion in Pharmacology, 2009
The importance of glutamate in the reinstatement of cocaine-seeking behavior has been established. New molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of CB1 receptor stimulation to reduce basal glutamate levels and the involvement of the GluR1 receptor subunit in
Lori A. Knackstedt, Peter W. Kalivas
openaire   +3 more sources

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Nature Communications, 2020
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa   +11 more
doaj   +1 more source

Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

Frontiers in Neurology, 2020
Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate ...
Allison R. Peterson, Devin K. Binder
doaj   +1 more source

The glutamate story [PDF]

British Journal of Pharmacology, 2006
Glutamatergic synaptic transmission in the mammalian central nervous system was slowly established over a period of some 20 years, dating from the 1950s. Realisation that glutamate and like amino acids (collectively known as excitatory amino acids (EAA)) mediated their excitatory actions via multiple receptors preceded establishment of these receptors ...
Watkins, JC, Jane, DE
openaire   +4 more sources