Results 1 to 10 of about 41,570 (221)

Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective This study was performed to reveal the molecular structure and expression patterns of horse glutamate-cysteine ligase catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM) genes whose products form glutamate cysteine ...
Jeong-Woong Park, Jae-Young Choi, Seul A Hong, Nam Young Kim, Kyoung-Tag Do, Ki-Duk Song, Byung-Wook Cho   +6 more
doaj   +5 more sources

Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis. [PDF]

Chembiochem, 2023
Abstract Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of cancer cells are particularly vulnerable to inhibition of their cellular antioxidant capacity. Glutamate‐cysteine ligase (GCL) is the first and rate‐limiting step in the synthesis of the major cellular antioxidant glutathione (GSH ...
Zhang LH, Tang M, Tao X, Shao Q, Thomas V, Shimizu S, Kasano M, Ishikawa Y, Inukai T, Nomura DK.   +9 more
europepmc   +5 more sources

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. [PDF]

Cell Metab, 2021
Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation beyond impairment of glutathione synthesis are poorly characterized.
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM.   +7 more
europepmc   +4 more sources

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma [PDF]

Advanced Science
Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High‐fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis.
Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng   +21 more
doaj   +2 more sources

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. [PDF]

Acta Neuropathol Commun, 2015
Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, such as cortical tubers and subependymal giant cell astrocytomas (SEGAs).
Malik AR, Liszewska E, Skalecka A, Urbanska M, Iyer AM, Swiech LJ, Perycz M, Parobczak K, Pietruszka P, Zarebska MM, Macias M, Kotulska K, Borkowska J, Grajkowska W, Tyburczy ME, Jozwiak S, Kwiatkowski DJ, Aronica E, Jaworski J.   +18 more
europepmc   +7 more sources

Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. [PDF]

Biomed Rep, 2014
Oxidative stress has been linked to the progression of mutations and cancer. Increased glutathione (GSH) contents have been observed in a number of different human cancer tissues. GSH is synthesized de novo in a two-step process catalyzed by glutamate cysteine ligase (GCL).
Li M, Zhang Z, Yuan J, Zhang Y, Jin X.
europepmc   +4 more sources

Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma. [PDF]

Jpn J Clin Oncol, 2018
Cisplatin is a key drug for treating lung adenocarcinoma, and its sensitivity to cisplatin is directly related to prognosis. We aimed to reveal the roles of genes related to glutathione synthesis (glutamate-cysteine ligase catalytic subunit, GCLC) and cystine uptake (cystine/glutamate transporter, xCT and CD44v8-10) in cisplatin resistance and ...
Hiyama N, Ando T, Maemura K, Sakatani T, Amano Y, Watanabe K, Kage H, Yatomi Y, Nagase T, Nakajima J, Takai D.   +10 more
europepmc   +4 more sources

Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. [PDF]

Oncol Lett, 2018
Previous metabolomic analyses of cancer have revealed elevated glutathione levels in tumors. An inhibitor of cystine uptake was identified to suppress glutathione biosynthesis, leading to ferroptosis, a novel iron-dependent form of cell death that differs from apoptosis and necrosis.
Nishizawa S, Araki H, Ishikawa Y, Kitazawa S, Hata A, Soga T, Hara T.   +6 more
europepmc   +4 more sources

Hydrogen sulfide upregulates glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit, and glutathione and inhibits interleukin-1β secretion in monocytes exposed to high glucose levels. [PDF]

Metab Syndr Relat Disord, 2014
Glutathione (GSH) deficiency and interleukin-1β (IL-1β) upregulation are linked to the progression of vascular inflammation and atherosclerosis. The consumption of sulfide-rich vegetables is known to lower the risk of atherosclerosis. This study examined the hypothesis that hydrogen sulfide (H2S) upregulates the glutamate-cysteine ligase catalytic ...
Jain SK, Huning L, Micinski D.
europepmc   +4 more sources

Knockdown of glutamate cysteine ligase catalytic subunit by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells. [PDF]

PLoS ONE, 2015
Gold nanoparticles (GNPs) have shown promising medical applications in cancer treatment involved in the regulation of intracellular redox balance. Previously, we have reported that GNPs can trigger apoptosis and necrosis in human lung cancer cells (A549)
Min Liu, Yunxue Zhao, Xiumei Zhang
doaj   +2 more sources