Results 201 to 210 of about 41,693 (219)

Research progress on the regulation of ferroptosis in NPC (Review). [PDF]

Oncol Rep
Bai S, Guo Y, Qiang J, Dai Q, Yang Y.
europepmc   +1 more source

The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance. [PDF]

Redox Biol
Chang L, Qin C, Wu J, Jiang H, Xu Q, Chen J, Xu X, Zhang X, Guan M, Deng X.   +9 more
europepmc   +1 more source

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Simulation Modeling of Glutamate Cysteine Ligase Activity

Biophysics, 2023
L-Y-glutamyl-L-cysteinyl glycine, or glutathione, as one of the basic intracellular antioxidants, plays a vital role in cellular metabolism. In mammalian cells, glutathione is synthesized via two steps. The first step that is considered rate limiting is catalyzed by glutamate cysteine ligase.
V. S Kopylova, S. E Boronovskiy, Ya. R Nartsissov   +2 more
openaire   +1 more source

Expression of glutamate‐cysteine ligase during mouse development

Molecular Reproduction and Development, 2002
AbstractThe tripeptide glutathione (GSH), which plays a crucial role in protecting cells against oxidative stress, is synthesized in a two‐step process. The rate‐limiting step is the binding of glutamate and cysteine, which is catalyzed by the enzyme glutamate‐cysteine ligase (GCL).
Dolores, Díaz, Cecile M, Krejsa, Terrance J, Kavanagh   +2 more
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Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Free Radical Biology and Medicine, 2004
Glutathione (GSH) is important in free radical scavenging, maintaining cellular redox status, and regulating cell survival in response to a wide variety of toxicants. The rate-limiting enzyme in GSH synthesis is glutamate-cysteine ligase (GCL), which is composed of catalytic (GCLC) and modifier (GCLM) subunits.
Dianne, Botta, Christopher C, Franklin, Collin C, White, Cecile M, Krejsa, Michael J, Dabrowski, Robert H, Pierce, Nelson, Fausto, Terrance J, Kavanagh   +7 more
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Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal

Free Radical Biology and Medicine, 2005
4-Hydroxynonenal (HNE) is one of the major end-products of lipid peroxidation and is increased in response to cellular stress and in many chronic and/or inflammatory diseases. HNE can in turn function as a potent signaling molecule to induce the expression of many genes including glutamate cysteine ligase (GCL), the rate-limiting enzyme in de novo ...
Karen E, Iles, Rui-Ming, Liu
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Molecular cloning and analysis of Ancylostoma ceylanicum glutamate–cysteine ligase

Molecular and Biochemical Parasitology, 2014
Glutamate-cysteine ligase (GCL) is a heterodimer enzyme composed of a catalytic subunit (GCLC) and a modifier subunit (GCLM). This enzyme catalyses the synthesis of γ-glutamylcysteine, a precursor of glutathione. cDNAs of the putative glutamate-cysteine ligase catalytic (Ace-GCLC) and modifier subunits (Ace-GCLM) of Ancylostoma ceylanicum were cloned ...
Marcin, Wiśniewski, Maciej, Lapiński, Anna, Zdziarska, Ewa, Długosz, Piotr, Bąska   +4 more
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Human glutamate cysteine ligase gene regulation through the electrophile response element

Free Radical Biology and Medicine, 2004
Glutathione (GSH) is the primary nonprotein thiol in the cell. It has many important roles in cell function, including regulating redox-dependent signal transduction pathways. The content of GSH within the cell varies with stress. In many cases, a process involving GSH synthesis results in adaptation to subsequent stressors.
Dale A, Dickinson, Anna-Liisa, Levonen, Douglas R, Moellering, Erin K, Arnold, Hongqiao, Zhang, Victor M, Darley-Usmar, Henry Jay, Forman   +6 more
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Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes

Molecular Biology Reports, 2020
Oxidative stress contributes to the pathogenesis of type 2 diabetes (T2D). This study investigated whether single nucleotide polymorphisms (SNPs) at genes encoding glutamate cysteine ligase catalytic (rs12524494, rs17883901, rs606548, rs636933, rs648595, rs761142 at GCLC) and modifier (rs2301022, rs3827715, rs7517826, rs41303970 at GCLM) subunits are ...
Iuliia Azarova, Elena Klyosova, Victor Lazarenko, Alexander Konoplya, Alexey Polonikov   +4 more
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Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase

Biochemical Pharmacology, 2007
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the glutathione (GSH) biosynthesis pathway. This enzyme is a heterodimer, comprising a catalytic subunit (GCLC) and a regulatory subunit (GCLM). Although GCLC alone can catalyze the formation of l-gamma-glutamyl-l-cysteine, its binding with GCLM enhances the enzyme activity by lowering the ...
Yi, Yang, Ying, Chen, Elisabet, Johansson, Scott N, Schneider, Howard G, Shertzer, Daniel W, Nebert, Timothy P, Dalton   +6 more
openaire   +2 more sources