Results 41 to 50 of about 41,693 (219)

Myeloperoxidase and glutamate-cysteine ligase polymorphisms in type 2 diabetes mellitus: A preliminary study [PDF]

Journal of Medical Biochemistry, 2014
Background: Oxidative stress can accompany the physiopathology of diabetes mellitus. Myeloperoxidase and glutamate-cysteine ligase catalytic subunit are two important substances which are connected with the maintaining of the redox balance in the body ...
Eksi Yunus Emre, Karaali Zeynep Ermiç, Ïncekara Kutluhan, Ergen H. Arzu   +3 more
doaj  

Dysregulation of glutathione synthesis in liver disease

Liver Research, 2020
Glutathione (GSH), a tripeptide that is present in all mammalian tissues, is especially highly concentrated in the liver. GSH synthesis occurs via two adenosine triphosphate (ATP)-requiring enzymatic steps: the first is rate-limiting, catalyzed by ...
Shelly C. Lu
doaj   +1 more source

Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability

Redox Biology, 2023
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly ...
Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede, Manisha Patel   +8 more
doaj   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Cysteine improves boar sperm quality via glutathione biosynthesis during the liquid storage [PDF]

Animal Bioscience, 2022
Objective Sperm is particularly susceptible to reactive oxygen species (ROS) stress. Glutathione (GSH) is an endogenous antioxidant that regulates sperm redox homeostasis.
Zhendong Zhu, Yao Zeng, Wenxian Zeng
doaj   +1 more source

Cytosolic Fe-S cluster protein maturation and iron regulation are independent of the mitochondrial Erv1/Mia40 import system [PDF]

, 2015
The sulfhydryl oxidase Erv1 partners with the oxidoreductase Mia40 to import cysteine-rich proteins in the mitochondrial intermembrane space. In Saccharomyces cerevisiae, Erv1 has also been implicated in cytosolic Fe-S protein maturation and iron ...
Adrienne C. Dlouhy, Allen, Aloria, Amutha, Askwith, Balk, Bedekovics, Bien, Bihlmaier, Biterova, Caryn E. Outten, Chacinska, Chen, Daithankar, Daum, Ferecatu, Fischer, Guo, Hatice K. Ozer, Hausmann, Herrmann, Hofhaus, Hu, Janneke Balk, Jeremy D. Thornton, Jingjing Hu, Joseph J. Barycki, Kispal, Kispal, Kumar, Lange, Lee, Lill, Lill, Lisowsky, Lisowsky, Livak, Mesecke, Miao, Miao, Mumberg, Müller, Netz, Outten, Outten, Philpott, Philpott, Poor, Rissler, Roy, Rutherford, Rutherford, Schaedler, Sideris, Sikorski, Sipos, Spiller, Srinivasan, Terziyska, Thorvaldsen, Tong, Ueta, Yamaguchi-Iwai, Yarunin, Yilin Liu, Zhang   +65 more
core   +2 more sources

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis

Redox Biology, 2018
Glutathione (GSH) biosynthesis is essential for cellular redox homeostasis and antioxidant defense. The rate-limiting step requires glutamate-cysteine ligase (GCL), which is composed of the catalytic (GCLc) and the modulatory (GCLm) subunits. To evaluate
Cristina Espinosa-Díez, Verónica Miguel, Susana Vallejo, Francisco J. Sánchez, Elena Sandoval, Eva Blanco, Pablo Cannata, Concepción Peiró, Carlos F. Sánchez-Ferrer, Santiago Lamas   +9 more
doaj   +1 more source

Zearalenone regulates key factors of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1–nuclear factor erythroid 2-related factor 2 signaling pathway in duodenum of post-weaning gilts [PDF]

Animal Bioscience, 2021
Objective This study explored the mechanism of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1)–nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway under conditions of zearalenone (ZEA)-induced
Qun Cheng, Shu zhen Jiang, Li bo Huang, Wei ren Yang, Zai bin Yang   +4 more
doaj   +1 more source

Роль полиморфизмов генов глутаматцистеинлигазы в развитии сахарного диабета 2 типа у жителей Курской области [PDF]

, 2018
Глутаматцистеинлигаза (GCL) является первым ферментом синтеза глутатиона, внутри- и внеклеточного антиоксиданта, нарушение обмена которого играет важную роль в патогенезе сахарного диабета 2 типа (СД2).
Азарова, Ю. Э., Клесова, Е. Ю., Конопля, А. И.   +2 more
core   +2 more sources

Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis

Free Radical Biology and Medicine, 2008
Glutathione depletion is a key factor in the development of acute pancreatitis. Our aim was to study the regulation of glutamate cysteine ligase, the rate-limiting enzyme in glutathione synthesis, in edematous or necrotizing pancreatitis in rats. Glutathione levels were kept low in necrotizing pancreatitis for several hours, with no increase in protein
Pereda, Javier, Escobar, Javier, Sandoval, Juan, Rodriguez, Jose Luis, Sabater, Luis, Pallardo, Federico V., Torres, Luis, Franco, Luis, Vina, Jose, Lopez-Rodas, Gerardo, Sastre, Juan   +10 more
openaire   +3 more sources