Results 51 to 60 of about 41,693 (219)

Structural Basis for the Redox Control of Plant Glutamate Cysteine Ligase [PDF]

Journal of Biological Chemistry, 2006
Glutathione (GSH) plays a crucial role in plant metabolism and stress response. The rate-limiting step in the biosynthesis of GSH is catalyzed by glutamate cysteine ligase (GCL) the activity of which is tightly regulated. The regulation of plant GCLs is poorly understood.
Michael, Hothorn, Andreas, Wachter, Roland, Gromes, Tobias, Stuwe, Thomas, Rausch, Klaus, Scheffzek   +5 more
openaire   +2 more sources

Induction of Glutathione Synthesis Provides Cardioprotection Regulating NO, AMPK and PPARa Signaling in Ischemic Rat Hearts

Life, 2021
Glutathione (GSH) is essential for antioxidant defence, and its depletion is associated with tissue damage during cardiac ischemia-reperfusion (I/R). GSH is synthesized by the glutamate-cysteine ligase enzyme (GCL) from L-cysteine, which alternatively ...
Yulia V. Goshovska, Raisa A. Fedichkina, Volodymyr V. Balatskyi, Oksana O. Piven, Pawel Dobrzyn, Vadym F. Sagach   +5 more
doaj   +1 more source

Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): The present study investigated whether morin has a protective effect against ACR-induced cardiac toxicity.Materials and Methods: In this study, oxidative stress, inflammation, endoplasmic reticulum stress (ERS), and apoptosis markers in ...
Fatma Cakmak, Sefa Kucukler, Cihan Gur, Mustafa Ileriturk, Murat Gul, Behcet Varisli   +5 more
doaj   +1 more source

The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity

Current Issues in Molecular Biology, 2022
Arecae Pericarpium has been found to exert anti-migraine, antidepressant, and antioxidative effects. However, the mechanisms involved are unclear. This study explored the possibility that Arecae Pericarpium ethanol extract (APE) exerts neuroprotective ...
Yun Hee Jeong, You-Chang Oh, Tae In Kim, Jong-Sup Bae, Jin Yeul Ma   +4 more
doaj   +1 more source

Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]

, 2013
The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model.
Aude-Garcia, Catherine, Carrière, Marie, Chevallet, Mireille, Collin-Faure, Véronique, Diemer, Hélène, Habert, Aurélie, Hanau, Daniel, Herlin-Boime, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +12 more
core   +5 more sources

Proteasome Lid Bridges Mitochondrial Stress with Cdc53/Cullin1 NEDDylation Status [PDF]

, 2019
Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle ...
Bramasole, L., Gefen, E., Glickman, M. H., Gurevich, S., Jimenez-Morales, D., Johnson, J., Klein, Y., Krogan, N. J., Panat, N., Pick, E., Radzinski, M., Reichmann, D., Reis, N., Rinaldi, T., Sinha, A.   +14 more
core   +1 more source

Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers [PDF]

European Respiratory Journal, 2003
The antioxidant glutathione (GSH) is increased in the epithelial lining fluid (ELF) of chronic smokers. The rate-limiting enzyme in GSH synthesis is glutamate-cysteine ligase (GCL), also known as γ‐glutamylcysteine synthetase, consisting of a heavy, catalytic (GCLC) and a light, modulatory (GCLM) subunit.To determine the contribution of bronchoalveolar
C, Neurohr, A G, Lenz, I, Ding, H, Leuchte, T, Kolbe, J, Behr   +5 more
openaire   +2 more sources

The Potential Relationship Between HIF-1α and Amino Acid Metabolism After Hypoxic Ischemia and Dual Effects on Neurons

Frontiers in Neuroscience, 2021
Hypoxia inducible factor (HIF) is one of the major transcription factors through which cells and tissues adapt to hypoxic-ischemic injury. However, the specific mechanism by which HIF regulates amino acid metabolism and its effect on neurons during ...
Kexin Li, Yang Zheng, Xiaoming Wang
doaj   +1 more source

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer [PDF]

, 2018
During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway ...
Altman, Biancur, Boulahbel, Briggs, Cairns, Cancer Genome Atlas Research Network, Chandel, Chio, Cong, Cox, Davidson, Davies, DeBerardinis, DeBerardinis, DeBerardinis, Deberardinis, DeNicola, Dixon, Fabrizio, Fellmann, Fernandez, Gaglio, Gao, Goldstein, Gorrini, Habib, Hanada, Hanahan, Hosios, Hu, Ishii, Itoh, Itoh, Jaramillo, Kim, King, Kobayashi, Konermann, Konstantinopoulos, Koppula, Lacey, Lane, Larson, Le Gal, Letouzé, Lewerenz, Lewis, Loenarz, Mayers, Mitsuishi, Muscarella, Nicklin, Nioi, Piskounova, Qie, Rhoads, Romero, Sato, Sayin, Sayin, Selak, Shibata, Shibata, Shin, Singh, Sleeman, Son, Taguchi, Tardito, Timmerman, Trachootham, Vander Heiden, Warburg, Watanabe, Waterfall, Welbourne, Wise, Wise, Xiang, Xiao, Yuneva, Yuneva   +81 more
core   +1 more source

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene [PDF]

The American Journal of Human Genetics, 2006
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in ...
Tosic, Mirjana, Ott, Jurg, Barral, Sandra, Bovet, Pierre, Deppen, Patricia, Gheorghita, Fulvia, Matthey, Marie-Louise, Parnas, Josef, Preisig, Martin, Saraga, Michael, Solida, Alessandra, Timm, Sally, Wang, August G, Werge, Thomas, Cuénod, Michel, Do, Kim Quang   +15 more
openaire   +3 more sources