Results 11 to 20 of about 585,844 (339)
Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy
Frontiers in Neurology, 2020 Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate ...
Allison R. Peterson, Devin K. Binder
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Beilstein Journal of Nanotechnology, 2020 Glutamate is the main excitatory neurotransmitter in the central nervous system and excessive extracellular glutamate concentration is a characteristic feature of stroke, brain trauma, and epilepsy.
Konstantin Paliienko +5 more
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Critical Neurotransmitters in the Neuroimmune Network
Frontiers in Immunology, 2020 Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and transmembrane receptors and ligands, membrane vesicles ...
Thomas Wesley Hodo +9 more
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Brain and Behavior, 2022 Introduction Intrinsic network connectivity becomes altered in pathophysiology. Noninvasive brain stimulation can modulate pathological functional networks in an attempt to restore the inherent response.
Sara A. Rafique, Jennifer K. E. Steeves
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Global trends in research of glutamate in epilepsy during past two decades: A bibliometric analysis
Frontiers in Neuroscience, 2022 Epilepsy affects more than 70 million people in the world. It is characterized by recurrent spontaneous seizures, and it is related to many neurological, cognitive, and psychosocial consequences.
Wei Wang +6 more
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Pivotal Enzyme in Glutamate Metabolism of Poly-g-Glutamate-Producing Microbes
Life, 2013 The extremely halophilic archaeon Natrialba aegyptiaca secretes the L-homo type of poly-g-glutamate (PGA) as an extremolyte. We examined the enzymes involved in glutamate metabolism and verified the presence of L-glutamate dehydrogenases, L-aspartate ...
Tohru Kamei +2 more
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Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells
Frontiers in Cellular Neuroscience, 2020 A plethora of neurological disorders shares a final common deadly pathway known as excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and disability worldwide.
Denisa Belov Kirdajova +3 more
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Neurobiology of Disease, 2020 Impaired behavioral flexibility and repetitive behavior is a common phenotype in autism and other neuropsychiatric disorders, but the underlying synaptic mechanisms are poorly understood.
Jinxu Liu +8 more
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A Mini-Review of the Role of Glutamate Transporter in Drug Addiction
Frontiers in Neurology, 2019 Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang +3 more
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Frontiers in Cellular Neuroscience, 2021 The astrocytic cystine/glutamate antiporter system xc– (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways in the brain that are dysregulated in age-related neurological ...
Eduard Bentea +11 more
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