Results 21 to 30 of about 732,660 (295)
A Mini-Review of the Role of Glutamate Transporter in Drug Addiction
Frontiers in Neurology, 2019 Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang +3 more
doaj +1 more source
The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders
Frontiers in Sports and Active Living, 2023 Physical activity (PA) is an effective way of increasing cognitive and emotional health and counteracting many psychiatric conditions. Numerous neurobiological models for depression have emerged in the past 30 years but many struggle to incorporate the ...
Richard Baskerville +2 more
doaj +1 more source
Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
Frontiers in Oncology, 2020 The observation that cancer acquires significant changes in its metabolism dates back nearly a century, to Otto Warburg noting that cancer cells preferentially utilize glycolysis even when there are no hypoxic conditions in the growth media.
Johannes F. Fahrmann +2 more
doaj +1 more source
Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan +3 more
doaj +1 more source
Biomolecules, 2016 Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
doaj +1 more source
Frontiers in Psychiatry, 2021 Proton magnetic resonance spectroscopy (MRS) studies in schizophrenia have shown altered GABAergic, glutamatergic, and bioenergetic pathways, but if these abnormalities are brain region or illness-stage specific is largely unknown.
S. Andrea Wijtenburg +6 more
doaj +1 more source
Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]
, 2014 In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura +74 more
core +2 more sources
Biomolecules, 2021 Oxidative stress is one of the main causes of brain cell death in neurological disorders. The use of natural antioxidants to maintain redox homeostasis contributes to alleviating neurodegeneration. Glutamate is an excitatory neurotransmitter that plays a
Tuy An Trinh +4 more
doaj +1 more source
Molecules, 2023 This study compared the neuroprotective efficacy of three antioxidants—the plant-derived carnosic acid (CA), and two synthetic free radical scavengers: edaravone (ED) and ebselen (EB)—in in vitro models of neuronal cell damage.
Danuta Jantas +2 more
doaj +1 more source
Locally-Induced CaMKII Translocation Requires Nucleotide Binding
Frontiers in Synaptic Neuroscience, 2020 Calcium-calmodulin-dependent protein kinase (CaMKII) is a molecule involved in several cell processes including plasticity related to learning and memory. Activation of NMDA-type glutamate receptors results in translocation of CaMKII to synapses. However,
Zachary T. Fitzgerald +1 more
doaj +1 more source