Results 31 to 40 of about 808,650 (427)
Biology, 2017 The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake.
Leif Hertz, Douglas L Rothman
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Glutamate triggers long-distance, calcium-based plant defense signaling
Science, 2018 Rapid, long-distance signaling in plants A plant injured on one leaf by a nibbling insect can alert its other leaves to begin anticipatory defense responses. Working in the model plant Arabidopsis, Toyota et al. show that this systemic signal begins with
M. Toyota +7 more
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A Mini-Review of the Role of Glutamate Transporter in Drug Addiction
Frontiers in Neurology, 2019 Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang +3 more
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N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users. [PDF]
, 2018 Background:Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in
Alger, Jeffry R +5 more
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Proceedings of the National Academy of Sciences of the United States of America, 1994 Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on ...
L. Pellerin, P. Magistretti
semanticscholar +1 more source
The Journal of Nutrition, 2000 Epileptic syndromes have very diverse primary causes, which may be genetic, developmental or acquired. In rodent models, altering glutamate receptor or glutamate transporter expression by knockout or knockdown procedures can induce or suppress epileptic seizures.
openaire +3 more sources
Disrupted Glutamate Signaling in Drosophila Generates Locomotor Rhythms in Constant Light
Frontiers in Physiology, 2020 We have used the Cambridge Protein Trap resource (CPTI) to screen for flies whose locomotor rhythms are rhythmic in constant light (LL) as a means of identifying circadian photoreception genes.
Renata Van De Maas de Azevedo +4 more
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Astrocyte glutamine synthetase : pivotal in health and disease [PDF]
, 2013 The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis.
Parpura, Vladimir +2 more
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Molecular Pain, 2005 Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate receptors.
Stephens Robert L +2 more
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d-glutamate and Gut Microbiota in Alzheimer’s Disease
International Journal of Molecular Sciences, 2020 Background: An increasing number of studies have shown that the brain–gut–microbiota axis may significantly contribute to Alzheimer’s disease (AD) pathogenesis. Moreover, impaired memory and learning involve the dysfunction neurotransmission of glutamate,
ChunLang Chang, Chieh-Hsin Lin, H. Lane
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