Results 51 to 60 of about 585,844 (339)

Efeitos do ácido L-glutâmico e da vitamina K na composição bioquímica parcial de fêmures de frangos de corte Effects of dietary L-glutamic acid and K vitamin in the biochemical composition in femurs of broilers at 14 days of age

Revista Brasileira de Zootecnia, 2010
Objetivou-se estudar os efeitos da combinação de ácido L-glutâmico (L-Glu) e vitamina K na composição bioquímica de fêmures (proteínas colagenosas; não-colagenosas e totais) de frangos de corte.
George Henrique Kling de Moraes, Ana Claudia Peres Rodrigues, Fernanda Álvares da Silva, Horacio Santiago Rostagno, Cibele Silva Minafra, Solange Mara Bigonha   +5 more
doaj   +1 more source

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model

Pharmaceuticals, 2021
The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their ...
Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik   +8 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A role for tumor necrosis factor-α in ischemia and ischemic preconditioning

Journal of Neuroinflammation, 2011
During cerebral ischemia, elevation of TNF-α and glutamate to pathophysiological levels may induce dysregulation of normal synaptic processes, leading ultimately to cell death.
O'Connor John J, Watters Orla
doaj   +1 more source

Molecular Characterization and Nutrition Regulation of the Neutral Amino Acid Transporter ASCT2 in Triploid Crucian Carp

Fishes, 2021
AlaSerCys Transporter 2 (ASCT2), encoded by the SLC1A5 gene, plays an important role in the absorption of glutamine. In this study, the full-length cDNA sequence of ASCT2 was cloned from triploid crucian carp.
Zhuangwen Mao, Shengwei Luo, Dafang Zhao, Xiang Zhou, Zilong Zhang, Yangbo Xiao, Shenping Cao, Yonghua Zhou, Shaojun Liu, Jianzhou Tang, Zhen Liu   +10 more
doaj   +1 more source

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

Nature Methods, 2018
Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) that are functionally brighter ...
J. Marvin, B. Scholl, Daniel E. Wilson, Kaspar Podgorski, Abbas Kazemipour, J. A. Müller, S. Schoch, F. J. U. Quiroz, N. Rebola, Huan Bao, J. P. Little, A. N. Tkachuk, Edward Cai, A. Hantman, S. Wang, Victor J. DePiero, B. Borghuis, E. Chapman, D. Dietrich, D. DiGregorio, D. Fitzpatrick, L. Looger   +21 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

Frontiers in Psychiatry, 2018
Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment.
Jennifer L. Jones, Camilo F. Mateus, Robert J. Malcolm, Kathleen T. Brady, Kathleen T. Brady, Sudie E. Back, Sudie E. Back   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders

Molecules, 2021
Statins are among the most widely used drug classes in the world. Apart from their basic mechanism of action, which is lowering cholesterol levels, many pleiotropic effects have been described so far, such as anti-inflammatory and antiatherosclerotic ...
Michał Kosowski, Joanna Smolarczyk-Kosowska, Marcin Hachuła, Mateusz Maligłówka, Marcin Basiak, Grzegorz Machnik, Robert Pudlo, Bogusław Okopień   +7 more
doaj   +1 more source