Results 51 to 60 of about 716,780 (343)

Disrupted GABAergic facilitation of working memory performance in people with schizophrenia. [PDF]

, 2020
ObjectivesGamma-Amiobutyric acid (GABA) is a primary inhibitory neurotransmitter that facilitates neural oscillations that coordinate neural activity between brain networks to facilitate cognition.
Carter, CS, Hurtado, MY, Lesh, TA, Maddock, RJ, Niendam, TA, Ragland, JD, Ranganath, C, Tanase, C   +7 more
core  

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Emerging Temporal Lobe Dysfunction in People at Clinical High Risk for Psychosis

Frontiers in Psychiatry, 2019
Clinical high-risk (CHR) individuals have been increasingly utilized to investigate the prodromal phases of psychosis and progression to illness. Research has identified medial and lateral temporal lobe abnormalities in CHR individuals.
Paul Allen, Paul Allen, Paul Allen, Holly Moore, Holly Moore, Cheryl M. Corcoran, James Gilleen, Petya Kozhuharova, Avi Reichenberg, Dolores Malaspina   +9 more
doaj   +1 more source

Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus

Brain Sciences, 2023
Zaleplon is a positive allosteric modulator of the γ-aminobutyric acid (GABA)A receptor approved for the short-term treatment of insomnia. Previous publications on zaleplon have not addressed the proteins involved in its mechanism of action but have ...
Jelena Martinovic, Janko Samardzic, Marina Zaric Kontic, Sanja Ivkovic, Sanja Dacic, Tamara Major, Milica Radosavljevic, Dubravka Svob Strac   +7 more
doaj   +1 more source

Glutamate Receptor [PDF]

, 2016
[No abstract]
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy

Frontiers in Neuroscience, 2018
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases.
Leila Bond, Kamren Bernhardt, Priyank Madria, Katherine Sorrentino, Hailee Scelsi, Hailee Scelsi, Cassie S. Mitchell   +6 more
doaj   +1 more source

Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

Frontiers in Neuroscience, 2021
Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only few options available for treating obesity, and most current pharmacotherapy causes severe ...
Tadeu P. D. Oliveira, Bruno D. C. Gonçalves, Bruna S. Oliveira, Antonio Carlos P. de Oliveira, Helton J. Reis, Claudia N. Ferreira, Daniele C. Aguiar, Aline S. de Miranda, Fabiola M. Ribeiro, Erica M. L. Vieira, András Palotás, András Palotás, Luciene B. Vieira   +12 more
doaj   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source