Results 51 to 60 of about 898,814 (388)

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

Nature Methods, 2018
Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) that are functionally brighter ...
J. Marvin, B. Scholl, Daniel E. Wilson, Kaspar Podgorski, Abbas Kazemipour, J. A. Müller, S. Schoch, F. J. U. Quiroz, N. Rebola, Huan Bao, J. P. Little, A. N. Tkachuk, Edward Cai, A. Hantman, S. Wang, Victor J. DePiero, B. Borghuis, E. Chapman, D. Dietrich, D. DiGregorio, D. Fitzpatrick, L. Looger   +21 more
semanticscholar   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jun, Xu, Hong, Peng, Ning, Kang, Zhuo, Zhao, Jane H-C, Lin, Patric K, Stanton, Jian, Kang   +6 more
openaire   +2 more sources

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3

Frontiers in Cellular Neuroscience, 2017
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs).
Haiyan Li, Magda S. Santos, Chihyung K. Park, Yuriy Dobry, Susan M. Voglmaier   +4 more
doaj   +1 more source

Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson’s Disease

Frontiers in Pharmacology, 2021
Our present objective was to better characterize the mechanisms that regulate striatal neuroinflammation in mice developing L-DOPA-induced dyskinesia (LID).
Maurício dos Santos Pereira, Maurício dos Santos Pereira, Maurício dos Santos Pereira, Maurício dos Santos Pereira, Gabriel Henrique Dias Abreu, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Bel, Elaine Del Bel, Elaine Del Bel   +12 more
doaj   +1 more source

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Glutamate transporter control of ambient glutamate levels

Neurochemistry International, 2014
Accurate knowledge of the ambient extracellular glutamate concentration in brain is required for understanding its potential impacts on tonic and phasic receptor signaling. Estimates of ambient glutamate based on microdialysis measurements are generally in the range of ∼2-10μM, approximately 100-fold higher than estimates based on electrophysiological ...
Sun, Weinan, Shchepakin, Denis, Kalachev, Leonid V., Kavanaugh, Michael P.   +3 more
openaire   +2 more sources

THE EFFECT OF SINGLE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL ON THE CONTENT OF NEUROACTIVE AMINO ACIDS IN THE BRAIN OF RATS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present.
Velichko I. M., Lelevich S. V., Lelevich V. V.   +2 more
doaj   +1 more source

Impaired Oligodendrocyte Development Following Preterm Birth: Promoting GABAergic Action to Improve Outcomes

Frontiers in Pediatrics, 2021
Preterm birth is associated with poor long-term neurodevelopmental and behavioral outcomes, even in the absence of obvious brain injury at the time of birth.
Julia C. Shaw, Julia C. Shaw, Gabrielle K. Crombie, Gabrielle K. Crombie, Hannah K. Palliser, Hannah K. Palliser, Jonathan J. Hirst, Jonathan J. Hirst   +7 more
doaj   +1 more source