Results 61 to 70 of about 716,780 (343)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]

, 2019
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason, Davis, Bethany, Fitzpatrick, James A.J., Gantz, Jay A, Hirose, Keiko, Kallogjeri, Dorina, Kim, Kyunghee X, Li, Song-Zhe, Ohlemiller, Kevin K, Payne, Shelby, Rutherford, Mark A, V-Ghaffari, Babak, Yang-Hood, Aizhen   +12 more
core   +1 more source

Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]

, 2004
The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Allen, Marcus James, DiAntonio, Aaron, Marrus, Scott B., Moffat, Kevin G., Portman, Scott L.   +4 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review

Frontiers in Psychiatry, 2022
Conventional monoamine-based pharmacotherapy, considered the first-line treatment for major depressive disorder (MDD), has several challenges, including high rates of non-response. To address these challenges, preclinical and clinical studies have sought
Ilya Demchenko, Ilya Demchenko, Vanessa K. Tassone, Sidney H. Kennedy, Sidney H. Kennedy, Sidney H. Kennedy, Sidney H. Kennedy, Katharine Dunlop, Katharine Dunlop, Katharine Dunlop, Katharine Dunlop, Venkat Bhat, Venkat Bhat, Venkat Bhat, Venkat Bhat   +14 more
doaj   +1 more source

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jane H.-C. Lin, Ning Kang, Zhuo Zhao, Hong Peng, Patric K. Stanton, Jian Kang, Jun Xu   +6 more
openaire   +3 more sources

Life without glutamate: the epigenetic effects of glutamate deletion [PDF]

Frontiers in Molecular Neuroscience, 2014
Li et al. (2013) studied ThVGdKO mice produced by genetic elimination of the genes for both vesicular transporters Vglut-1 and Vglut-2. In these mice thalamocortical glutamate neurotransmission in somatosensory cortex (but not in visual or auditory cortex) is silenced or knocked-out, thereby disabling the release of glutamate from synaptic vesicles ...
John Smythies, Kjell Fuxe, Lawrence Edelstein   +2 more
openaire   +4 more sources

Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]

, 2007
Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Hearing, Matthew, Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R.   +7 more
core   +1 more source

Superoxide reductase from Giardia intestinalis: structural characterization of the first sor from a eukaryotic organism shows an iron centre that is highly sensitive to photoreduction [PDF]

, 2015
Superoxide reductase (SOR), which is commonly found in prokaryotic organisms, affords protection from oxidative stress by reducing the superoxide anion to hydrogen peroxide.
Bandeiras, Tiago M., Carpentier, Philippe, Giuffre', Alessandro, Matias, Pedro M., Pinho, Filipa, Romão, Célia V., Sarti, Paolo, Sousa, Cristiana M., Testa, Fabrizio   +8 more
core   +2 more sources

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source