Results 201 to 210 of about 2,596,775 (326)

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Fenofibrate as a PPARα Agonist Modulates Neuroinflammation and Glutamate Receptors in a Rat Model of Temporal Lobe Epilepsy: Region-Specific Effects and Behavioral Outcomes. [PDF]

Int J Mol Sci
Kovalenko AA, Zakharova MV, Zubareva OE, Schwarz AP, Skorik YA, Zaitsev AV.   +5 more
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

The gating properties of Drosophila NMJ glutamate receptors and their dependence on Neto. [PDF]

J Physiol
Han TH, Vicidomini R, Ramos CI, Mayer ML, Serpe M.   +4 more
europepmc   +1 more source

Metabotropic Glutamate Receptor 5 Antagonism with Fenobam [PDF]

, 2011
Michael C. Montana, Beth A. Conrardy, Laura F. Cavallone, Benedict J. Kolber, Lesley K. Rao, Suellen Greco, Robert W. Gereau   +6 more
openalex   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Di Menna L, Alborghetti M, De Bartolo MI, Borro M, Gentile G, Zinni M, Bologna M, Cutrona C, D'Errico G, Imbriglio T, Bucci D, Merlo S, Ginerete RP, Orlando R, Carrillo F, Fortunato G, Cannella M, Sortino MA, Pansiot J, Baud O, Nicoletti F, Bruno V, Simmaco M, Pontieri FE, Bianchini E, Rinaldi D, de Curtis A, De Gaetano G, Iacoviello L, Esposito T, Berardelli A, Battaglia G.   +31 more
europepmc   +1 more source

Glutamate receptor (NMDA receptor) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

Proceedings of the National Academy of Sciences of the United States of America, 2013
E. Doumazane, P. Scholler, L. Fabre, J. Zwier, E. Trinquet, J. Pin, P. Rondard   +6 more
semanticscholar   +1 more source

Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus

, 2014
Tobias Loddenkemper, Delia M. Talos, Ryan T. Cleary, Annelise Joseph, Iván Sánchez Fernández, Andreas V. Alexopoulos, Prakash Kotagal, Imad Najm, Frances E. Jensen   +8 more
openalex   +2 more sources