Results 231 to 240 of about 2,596,775 (326)

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

S-Sulfocysteine's toxic effects on HT-22 cells are not triggered by glutamate receptors, nor do they involve apoptotic or genotoxicity mechanisms. [PDF]

Cytotechnology
Tekin V, Altintas F, Oymak B, Unal EB, Tunc-Ata M, Elmas L, Kucukatay V.   +6 more
europepmc   +1 more source

ZSF1 lean rats – How healthy are they?

Animal Models and Experimental Medicine, EarlyView.
This study aimed to examine the health status, specifically the physiology and myocardial, vascular, and skeletal muscle function of lean ZSF1 rats by comparing them to age‐ and sex‐matched Wistar rats. Compared to Wistar controls, ZSF1 lean rats exhibited lower body weight, but showed increased heart, and skeletal muscle mass.
Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein   +4 more
wiley   +1 more source

Activation of ionotropic and group I metabotropic glutamate receptors stimulates kisspeptin neuron activity in mice. [PDF]

J Neuroendocrinol
Bearss RJ, Oliver IA, Neuman PN, Abdulmajeed WI, Ackerman JM, Piet R.   +5 more
europepmc   +1 more source

Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum

, 2017
Kari A. Johnson, Yolanda Mateo, David M. Lovinger   +2 more
openalex   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

Animal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo, Ru Ye, Lu Guan, Wei He, Shuang Qiu, Xiaomei Shao, Junfan Fang, Jianqiao Fang, Junying Du   +8 more
wiley   +1 more source

Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population. [PDF]

Front Endocrinol (Lausanne)
Fernández R, Ramírez K, Lorente-Bermúdez R, Gómez-Gil E, Mora M, Guillamon A, Pásaro E.   +6 more
europepmc   +1 more source

The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment

Journal of neural transmission, 2014
D. Rojas
semanticscholar   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Whole Nervous System Expression of Glutamate Receptors Reveals Distinct Receptor Roles in Sensorimotor Circuits. [PDF]

eNeuro
Borba C, Kourakis MJ, Miao Y, Guduri B, Deng J, Smith WC.   +5 more
europepmc   +1 more source