Results 1 to 10 of about 678,593 (351)

Differential hydrophobicity drives self-assembly in Huntington's disease [PDF]

, 2003
Identifying the driving forces and the mechanism of association of huntingtin-exon1, a close marker for the progress of Huntington's disease, is an important prerequisite towards finding potential drug targets, and ultimately a cure. We introduce here a modelling framework based on a key analogy of the physico-chemical properties of the exon1 fragment ...
Chen, Ding, Discher, Fredrickson, Georgalis, Groot, Hoffner, Hoogeveen, Kelly, Lunkes, Masino, McGowan, Miyazawa, Perutz, Perutz, Ross, Scherzinger   +16 more
arxiv   +3 more sources

Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis [PDF]

Journal of Nutrition and Metabolism, 2016
Glutamine supplementation in specific groups of critically ill patients results in favourable clinical outcome. Enhancement of citrulline and arginine synthesis by glutamine could serve as a potential mechanism.
Mechteld A. R. Vermeulen, Saskia J. H. Brinkmann, Nikki Buijs, Albertus Beishuizen, Pierre M. Bet, Alexander P. J. Houdijk, Johannes B. van Goudoever, Paul A. M. van Leeuwen   +7 more
doaj   +3 more sources

Glutamine supplementation [PDF]

Annals of Intensive Care, 2011
Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given.
A Berg, A Berg, A Berg, A Berg, A Berg, Anonymous, AP Houdijk, B Ahlman, BA Van Acker, C Goeters, C Jones, D Darmaun, D Darmaun, D Dvir, D Garrel, DC Gore, DK Heyland, DK Heyland, DK Heyland, E Roth, EA Newsholme, EA Newsholme, F Hammarqvist, F Novak, F Simpson, GC Melis, GS Doig, H Barle, HM Oudemans-van Straaten, I Tjader, J Schroeder, J Wernerman, J Wernerman, JA Krishnan, JC Hall, JO Clemmesen, JV Peter, KS Kuhn, L Gamrin, L Gramlich, P Dechelotte, P Singer, P Singer, PC Rodas, PE Marik, PE Marik, PE Marik, PJ Andrews, PJ Andrews, R Conejero, RD Griffiths, RJ Beale, S Claeyssens, YP Zhou   +53 more
core   +5 more sources

A tracer bolus method for investigating glutamine kinetics in humans. [PDF]

PLoS ONE, 2014
Glutamine transport between tissues is important for the outcome of critically ill patients. Investigation of glutamine kinetics is, therefore, necessary to understand glutamine metabolism in these patients in order to improve future intervention studies.
Maiko Mori, Marie Smedberg, Maria Klaude, Inga Tjäder, Ake Norberg, Olav Rooyackers, Jan Wernerman   +6 more
doaj   +4 more sources

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets [PDF]

Cell Communication and Signaling
Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. Moreover, it is widely known that glutamine metabolism is reprogrammed in cancer cells.
Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu   +9 more
doaj   +2 more sources

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

International Journal of Molecular Sciences, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
core   +7 more sources

The Glutaminase-Dependent Acid Resistance System: Qualitative and Quantitative Assays and Analysis of Its Distribution in Enteric Bacteria [PDF]

Frontiers in Microbiology, 2018
Neutralophilic bacteria have developed several strategies to overcome the deleterious effects of acid stress. In particular, the amino acid-dependent systems are widespread, with their activities overlapping, covering a rather large pH range, from 6 to ...
Eugenia Pennacchietti, Chiara D'Alonzo, Luca Freddi, Alessandra Occhialini, Daniela De Biase   +4 more
doaj   +12 more sources

Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. [PDF]

PLoS ONE, 2012
Glutamine plays a central role in the metabolism of critical biological molecules such as amino acids, proteins, neurotransmitters, and glutathione. Since glutamine metabolism is regulated through multiple enzymes and transporters, the cellular glutamine
Katrin Gruenwald, John Todd Holland, Verlyn Stromberg, Altaf Ahmad, Daisy Watcharakichkorn, Sakiko Okumoto   +5 more
doaj   +6 more sources

Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. [PDF]

PLoS ONE, 2012
Glutamine is the most abundant free amino acid in the human blood stream and is 'conditionally essential' to cells. Its intracellular levels are regulated both by the uptake of extracellular glutamine via specific transport systems and by its ...
Jianmin Chen, Karl Herrup
doaj   +6 more sources

Targeting the glutamine-arginine-proline metabolism axis in cancer [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism.
Di Wang, Jiang-jie Duan, Yu-feng Guo, Jun-jie Chen, Tian-qing Chen, Jun Wang, Shi-cang Yu   +6 more
doaj   +3 more sources