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Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine, 2023 Further insights into metabolic reprogramming by cancer cells are needed to determine if targeting glutamine metabolism could be a useful therapeutic approach. Cancer cells rely on the amino acid glutamine for growth and proliferation. Glutamine is a key
J. Jin +3 more
semanticscholar +1 more source
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Nature, 2023 Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood^ 1 , 2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against ...
Chuansheng Guo +14 more
semanticscholar +1 more source
Nature Immunology, 2023 Unlike metabolic reprogramming that is characteristic of macrophage inflammatory polarization responses to lipopolysaccharide and TLR4 stimulation, the metabolism underlying inflammatory responses to CD40 signaling is not well characterized.
Pu-Ste Liu +11 more
semanticscholar +1 more source
Cell Communication and Signaling, 2022 Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma +10 more
semanticscholar +1 more source
Enteral Glutamine Modulates Renal Glutamine Utilization [PDF]
The Journal of Nutrition, 1996 Enteral glutamine feeding effect on renal glutamine utilization was assessed from the perspective of gamma glutamyltransferase activity-dependent cellular glutamate modulation of phosphate-dependent glutaminase. After 4d, rats fed an elemental diet supplemented with glutamine exhibited a 2 1 % higher kidney glutamate content and 27% reduction in ...
T, Welbourne, X, Mu, S, Evans
openaire +2 more sources
Journal of Hematology & Oncology, 2022 Background Besides featured glucose consumption, recent studies reveal that cancer cells might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); however, the underlying mechanisms remain unclear.
Tongyan Liu +21 more
semanticscholar +1 more source
Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap
Cancers, 2022 Simple Summary Dysregulated glutamine metabolism is one of the metabolic features evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for energy generation as well as the synthesis of other molecules that are critical ...
A. Halama, K. Suhre
semanticscholar +1 more source
JCI Insight, 2022 Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI), we show that glutamine significantly ...
Katharina Thomas +22 more
semanticscholar +1 more source
Glutamine reliance in cell metabolism
Experimental and Molecular Medicine, 2020 As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis.
H. Yoo +3 more
semanticscholar +1 more source
Glutamine, MTOR and autophagy: a multiconnection relationship
Autophagy, 2022 Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation.
C. Bodineau +3 more
semanticscholar +1 more source