Results 1 to 10 of about 50 (50)
Journal of British Surgery, 1996 Abstract Glutamine is the most abundant free amino acid in the circulation. It is a primary fuel for rapidly dividing cells and plays a key role in the transport of nitrogen between organs. Although glutamine is absent from conventional regimens aimed at nutritional support, glutamine deficiency can occur during periods of metabolic ...
J C, Hall, K, Heel, R, McCauley
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The Journal of Nutrition, 2001 Since the pioneering work of Windmueller and Spaeth, the importance of glutamine to the support of intestinal mucosal metabolic function has become generally accepted. Nevertheless, the mechanisms underlying this role still remain obscure. This paper explores a number of questions: 1) Is glutamine essential for intestinal function?
Peter J. Reeds, Douglas G. Burrin
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Glutamine supplementation [PDF]
Annals of Intensive Care, 2011 Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority
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Role of glutamine synthetase in angiogenesis beyond glutamine synthesis [PDF]
Nature, 2018 Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glutamine levels.
Jaap D. van Buul +46 more
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Enteral Glutamine Modulates Renal Glutamine Utilization [PDF]
The Journal of Nutrition, 1996 Enteral glutamine feeding effect on renal glutamine utilization was assessed from the perspective of gamma glutamyltransferase activity-dependent cellular glutamate modulation of phosphate-dependent glutaminase. After 4d, rats fed an elemental diet supplemented with glutamine exhibited a 2 1 % higher kidney glutamate content and 27% reduction in ...
Sarah Evans, Xinjie Mu, Tom Welbourne
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The Journal of Nutrition, 2001 Glutamine is the most abundant free amino acid in the human body; it is essential for the growth of normal and neoplastic cells and for the culture of many cell types. Cancer has been described as a nitrogen trap. The presence of a tumor produces great changes in host glutamine metabolism in such a way that host nitrogen metabolism is accommodated to ...
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Glutamine Transport and the Role of the Glutamine Translocator in Chloroplasts [PDF]
Plant Physiology, 1988 The transport of l-[(14)C]glutamine in oat (Avena sativa L.) and spinach (Spinacia oleracea L.) chloroplasts was studied by a conventional single-layer and a newly developed stable double-layer silicone oil filtering system. [(14)C]Glutamine was actively transported into oat chloroplasts against a concentration gradient.
Jian-Wei Yu, K. C. Woo
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Sirt4: The Glutamine Gatekeeper [PDF]
Cancer Cell, 2013 Little is known about how DNA damage and metabolism are interconnected. In this issue of Cancer Cell, Jeong and colleagues report that an important component of the DNA damage response is the SIRT4-mediated blockade of glutamine catabolism. Failure to shut down glutamine consumption results in unscheduled proliferation, genomic instability, and cancer.
Pablo J. Fernandez-Marcos +1 more
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The Regulation of Glutamine Metabolism in Candida utilis: the Role of Glutamine in the Control of Glutamine Synthetase [PDF]
Journal of General Microbiology, 1974 SUMMARY: In Candida utilis, the amount of glutamine synthetase is finely attuned to the availability of ammonia in the culture medium, and any change in ammonia availability results in a compensatory adjustment to enzyme level. In yeast growing with different sources of nitrogen there was a good inverse correlation between the rate of enzyme synthesis ...
A. P. Sims, A. R. Ferguson
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Glutamine as an Immunonutrient
Yonsei Medical Journal, 2011 Dietary supplementation with nutrients enhancing immune function is beneficial in patients with surgical and critical illness. Malnutrition and immune dysfunction are common features in hospitalized patients. Specific nutrients with immunological and pharmacological effects, when consumed in amounts above the daily requirement, are referred to as ...
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