Results 1 to 10 of about 521,415 (344)
Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine, 2023 Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide ...
Jonghwa Jin +3 more
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Cell Communication and Signaling, 2022 Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma +10 more
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eLife, 2020 The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine.
Haojie Jin +13 more
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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiers in Oncology, 2023 Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni +6 more
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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Nature, 2023 Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood^ 1 , 2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against ...
Chuansheng Guo +14 more
semanticscholar +1 more source
Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
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A tracer bolus method for investigating glutamine kinetics in humans. [PDF]
PLoS ONE, 2014 Glutamine transport between tissues is important for the outcome of critically ill patients. Investigation of glutamine kinetics is, therefore, necessary to understand glutamine metabolism in these patients in order to improve future intervention studies.
Maiko Mori +6 more
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Journal of Hematology & Oncology, 2022 Background Besides featured glucose consumption, recent studies reveal that cancer cells might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); however, the underlying mechanisms remain unclear.
Tongyan Liu +21 more
semanticscholar +1 more source
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. [PDF]
PLoS Genetics, 2011 Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements.
Hsiu-Ni Kung +2 more
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Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
Frontiers in Pharmacology, 2022 Glutamine is a conditionally essential amino acid involved in energy production and redox homeostasis. Aging is commonly characterized by energy generation reduction and redox homeostasis dysfunction.
Jiao Zhou +10 more
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