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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiers in Oncology, 2023 Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni +6 more
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Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
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A tracer bolus method for investigating glutamine kinetics in humans. [PDF]
PLoS ONE, 2014 Glutamine transport between tissues is important for the outcome of critically ill patients. Investigation of glutamine kinetics is, therefore, necessary to understand glutamine metabolism in these patients in order to improve future intervention studies.
Maiko Mori +6 more
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Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. [PDF]
PLoS Genetics, 2011 Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements.
Hsiu-Ni Kung +2 more
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Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
Frontiers in Pharmacology, 2022 Glutamine is a conditionally essential amino acid involved in energy production and redox homeostasis. Aging is commonly characterized by energy generation reduction and redox homeostasis dysfunction.
Jiao Zhou +10 more
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Scientific Reports, 2022 Glutamine provides carbon and nitrogen for macromolecular synthesis and participates in adenosine triphosphate (ATP) generation, anabolic metabolism, redox homeostasis, cell signaling, and cancer stem cell (CSC) metabolism.
Yoojeong Seo +3 more
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JIMD Reports, 2020 Succinic semialdehyde dehydrogenase deficiency (SSADHD) manifests with low levels of glutamine in the brain, suggesting that central glutamine deficiency contributes to pathogenesis.
Madalyn N. Brown +6 more
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Glutamine deprivation triggers NAGK-dependent hexosamine salvage
eLife, 2021 Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation ...
Sydney Campbell +12 more
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Molecules, 2023 As a group of naturally occurring peptides in various foods, γ-glutamyl peptides possess a unique Kokumi taste and health benefits. However, few studies have focused on the functionality of γ-glutamyl peptides. In this study, the γ-[glutamyl] (n=1, 2, 3)-
Wenjiang He +4 more
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Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts
Journal of Animal Science and Biotechnology, 2012 Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine.
Manso Helena +5 more
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