Results 31 to 40 of about 838,663 (376)

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

JCI Insight, 2022
Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI), we show that glutamine significantly ...
Katharina Thomas, L. Zondler, Nadine Ludwig, Marina Kardell, Corinna Lüneburg, Katharina Henke, Sina Mersmann, A. Margraf, Tilmann Spieker, T. Tekath, A. Velic, Richard Holtmeier, J. Hermann, V. Jankowski, M. Meersch, D. Vestweber, Martin Westphal, J. Roth, M. Schaefers, J. Kellum, C. Lowell, J. Rossaint, A. Zarbock   +22 more
semanticscholar   +1 more source

Therapeutic Potential of Glutamine Pathway in Lung Cancer

Frontiers in Oncology, 2022
Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including ...
Enyu Tang, Siyang Liu, Zhiming Zhang, Rixin Zhang, Dejing Huang, Tong Gao, Tianze Zhang, Guangquan Xu   +7 more
doaj   +1 more source

Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine [PDF]

, 2007
Phosphoribosylamine (PRA) is the first intermediate in the common pathway to purines and thiamine and is generated in bacteria by glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) from PRPP and glutamine.
Downs, Diana M., Koenigsknecht, Mark J., Ramos, Itzel   +2 more
core   +2 more sources

Glutamine, MTOR and autophagy: a multiconnection relationship

Autophagy, 2022
Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation.
C. Bodineau, M. Tomé, P. S. Murdoch, Raúl V. Dúran   +3 more
semanticscholar   +1 more source

Distinct Roles of Perilipins in the Intramuscular Deposition of Lipids in Glutamine-Supplemented, Low-, and Normal-Birth-Weight Piglets

Frontiers in Veterinary Science, 2021
Piglets with low birth weight (LBW) usually have reduced muscle mass and increased lipid deposition compared with their normal-birth-weight (NBW) littermates.
Yaolu Zhao, Elke Albrecht, Zeyang Li, Johannes Schregel, Quentin L. Sciascia, Cornelia C. Metges, Steffen Maak   +6 more
doaj   +1 more source

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Science, 2019
A fresh look at glutamine targeting Glutamine is essential for tumor growth and has long been an attractive therapeutic target for cancer researchers. Some attempts at blocking glutamine metabolism in cancer patients resulted in toxicity, prompting Leone
R. Leone, Liang Zhao, J. Englert, Im-Meng Sun, M. Oh, Im-Hong Sun, Matthew L. Arwood, Ian A. Bettencourt, Chirag H. Patel, Jiayu Wen, A. Tam, R. Blosser, Eva Prchalová, J. Alt, R. Rais, B. Slusher, J. Powell   +16 more
semanticscholar   +1 more source

Glutamine and Its Effects on the Intestine

Canadian Journal of Gastroenterology, 1991
Glutamine, an amino acid, is the principal energy substrate for small intestinal cells. It also acts as a nitrogen carrier through its amide nitrogen. Arterial glutamine is supported by net synthesis in skeletal muscle.
Paul E Hardy, Richard N Fedorak, Alan BR Thomson, Olin G Thurston   +3 more
doaj   +1 more source

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

Nutrients, 2018
Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater than glucose. For instance, in vitro and in vivo studies have determined that glutamine is
V. Cruzat, M. Macedo Rogero, Kevin Noel Keane, R. Curi, P. Newsholme   +4 more
semanticscholar   +1 more source