Results 31 to 40 of about 472,248 (234)

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance

Frontiers in Oncology, 2021
Tumor cells develop a series of metabolic reprogramming mechanisms to meet the metabolic needs for tumor progression. As metabolic hubs in cells, mitochondria play a significant role in this process, including energy production, biosynthesis, and redox ...
Xianglai Ye, Xianglai Ye, Xianglai Ye, Xiujuan Wei, Xiujuan Wei, Xiujuan Wei, Jing Liao, Jing Liao, Jing Liao, Peipei Chen, Peipei Chen, Peipei Chen, Xueyun Li, Xueyun Li, Xueyun Li, Yulong Chen, Yulong Chen, Yulong Chen, Yue Yang, Yue Yang, Yue Yang, Qiongya Zhao, Hongwei Sun, Liming Pan, Guorong Chen, Xujun He, Jianxin Lyu, Jianxin Lyu, Jianxin Lyu, Jianxin Lyu, Jianxin Lyu, Hezhi Fang, Hezhi Fang, Hezhi Fang   +33 more
doaj   +1 more source

Possibility of medicinal correction of disorders in metabolic cycle of neurotoxic transmitter glutamate in retina with neurotropic drugs during experimental glaucoma

Patologìâ, 2012
Adult rabbits with experimental glaucoma were used in this study. We studied glutamate and glutamine levels and glutamine synthetase, glutamate oxidase and glutaminase activity in the eye tissue during glaucoma process.
V. M. Serdyuk
doaj   +1 more source

Glutamine Cooperatively Upregulates Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells through the ERK and Nrf-2/HO-1 Signaling Pathway

Antioxidants, 2020
Glutamine (Gln) is a nonessential α-amino acid for protein biosynthesis. However, the mechanism through which Gln regulates NO production in microglial cells is still unclear.
Rajapaksha Gedara Prasad Tharanga Jayasooriya, Ilandarage Menu Neelaka Molagoda, Matharage Gayani Dilshara, Yung Hyun Choi, Gi-Young Kim   +4 more
doaj   +1 more source

A metabolic shift toward glycolysis enables cancer cells to maintain survival upon concomitant glutamine deprivation and V-ATPase inhibition

Frontiers in Nutrition, 2023
It is widely known that most cancer cells display an increased reliance on glutaminolysis to sustain proliferation and survival. Combining glutamine deprivation with additional anti-cancer therapies is an intensively investigated approach to increase ...
Florian Lengauer, Franz Geisslinger, Antje Gabriel, Karin von Schwarzenberg, Angelika M. Vollmar, Karin Bartel   +5 more
doaj   +1 more source

Glutamine: A novel approach to chemotherapy-induced toxicity

Indian Journal of Medical and Paediatric Oncology, 2012
Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as ...
Kumar Gaurav, R K Goel, Mridula Shukla, Manoj Pandey   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Nucleic Acid Metabolism in Patients with Severe Burn Injury and the Possibility of Its Correction

Общая реаниматология, 2019
Purpose. To assess changes in nucleic acid (NA) metabolism in severe burn injury and to develop recommendations for correction of the alimentary status taking into account changes in the NA metabolism. Materials and methods.
E. I. Vereshchagin, I. M. Mitrofanov, I. Yu. Samatov, E. I. Strel'tsova, A. L. Veinberg, E. A. Potter, S. S. Bogachov   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Evaluation of HSP70 deficiency in the inflammatory response in vivo and in vitro: The impact of HSP90 expression, glucocorticoid release, and glutamine administration

Journal of Biological Research - Thessaloniki, 2022
The present study aimed to explore the pathway through which Heat Shock Protein 70 (HSP70) is involved in inflammation and sepsis and the possible interaction with glutamine, an essential nutrient during sepsis. We also evaluated the possible interaction
Ioanna Plati, Olga Rassouli, Eirini Dermitzaki, Eleftheria Ieronymaki, George Briassoulis, Maria Venihaki   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source