Results 61 to 70 of about 838,663 (376)

A Phase 3 Trial of l‐Glutamine in Sickle Cell Disease

New England Journal of Medicine, 2018
BACKGROUND Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical‐grade l‐glutamine (USAN, glutamine) has been shown to increase the proportion of the reduced form of nicotinamide adenine ...
Y. Niihara, Scott T. Miller, J. Kanter, S. Lanzkron, Wally R. Smith, L. Hsu, V. Gordeuk, K. Viswanathan, S. Sarnaik, I. Osunkwo, Edouard Guillaume, S. Sadanandan, L. Sieger, Joseph L. Lasky, E. Panosyan, Osbourne A. Blake, T. New, R. Bellevue, Lan T. Tran, R. Razon, C. Stark, L. Neumayr, E. Vichinsky   +22 more
semanticscholar   +1 more source

Alloferon Affects the Chemosensitivity of Pancreatic Cancer by Regulating the Expression of SLC6A14

Biomedicines, 2022
Pancreatic cancer (PCa), one of the most malignant solid tumors, has a high mortality rate. Although there have been many trials of chemotherapeutic drugs such as gemcitabine, the mortality rates remain significantly higher than for other types of cancer.
Hyejung Jo, Dahae Lee, Cheolhyeon Go, Yoojin Jang, Suhyun Bae, Tomoyo Agura, Jiye Hong, Dongmin Kang, Yejin Kim, Jae Seung Kang   +9 more
doaj   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Glutamine Synthetase as a Therapeutic Target for Cancer Treatment

International Journal of Molecular Sciences, 2021
The significance of glutamine in cancer metabolism has been extensively studied. Cancer cells consume an excessive amount of glutamine to facilitate rapid proliferation.
Go-woon Kim, Dong Hoon Lee, Y. H. Jeon, Jung Yoo, So Yeon Kim, Sang Wu Lee, H. Cho, S. Kwon   +7 more
semanticscholar   +1 more source

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
core   +2 more sources

Glutamine addiction in tumor cell: oncogene regulation and clinical treatment

Cell Communication and Signaling
 After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation.
Xian Li, Xueqiang Peng, Yan Li, Shibo Wei, Guangpeng He, Jiaxing Liu, Xinyu Li, Shuo Yang, Dai Li, Weikai Lin, Jia-Wei Fang, Liang Yang, Hangyu Li   +12 more
semanticscholar   +1 more source

Effect of glutamine, glucose unhidrate and Moringa oleifera on blood lymphocytes in white mice (Rattus Novergicus) Wistar strain, following induction of a protein energy-deficient diet

Journal of Public Health in Africa, 2022
The aim of this research was studied the influence of giving Glutamine, Glucose Unhydrate and Moringa oleifera the blood lymphocyte of white rat (Rattus novergicus) Strain Wistar that was induced with protein energy malnutrtion (PEM).
Septa Katmawanti, Moch Yunus, Ari Wibowo Kurniawan, Anita Sulistyorini, Rosuzeita Fauzi, Supriyadi Supriyadi, Dea Amanda Caressa, Dea Aflah Samah, Oktavia Sri Wahyuni, Aquila Ghafril Azizah   +9 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]

, 2017
Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra, De Tullio, Giacoma, Ghesquière, Bart, Guarini, Attilio, Hooper, D Craig, Lamers, Wouter H., Martín-Pérez, Rosa, Mazzone, Massimiliano, McVicar, Daniel W., Menga, Alessio, Palmieri, Erika M., Quinto, Annamaria, Riera-Domingo, Carla   +12 more
core   +8 more sources

Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia

Brazilian Journal of Medical and Biological Research, 2001
Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated. For this purpose, livers were perfused with a saturating concentration of 2 mM glycerol, 5 mM L-alanine or 5 mM L-glutamine as gluconeogenic ...
H.M. de Souza, G.R. Borba-Murad, R.B. Ceddia, R. Curi, M. Vardanega-Peicher, R.B. Bazotte   +5 more
doaj   +1 more source