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Glutathione synthesis. [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) is present in all mammalian tissues as the most abundant non-protein thiol that defends against oxidative stress. GSH is also a key determinant of redox signaling, vital in detoxification of xenobiotics, and regulates cell proliferation, apoptosis, immune function, and fibrogenesis.
Shelly C. Lu
semanticscholar   +3 more sources

Glutathione [PDF]

open access: yesThe Arabidopsis Book, 2011
Glutathione is a simple sulfur compound composed of three amino acids and the major non-protein thiol in many organisms, including plants. The functions of glutathione are manifold but notably include redox-homeostatic buffering. Glutathione status is modulated by oxidants as well as by nutritional and other factors, and can influence protein structure
Graham, Noctor   +4 more
openaire   +2 more sources

Glutathione Transferases [PDF]

open access: yesThe Arabidopsis Book, 2010
The 55 Arabidopsis glutathione transferases (GSTs) are, with one microsomal exception, a monophyletic group of soluble enzymes that can be divided into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR) and TCHQD classes. The populous phi and tau classes are often highly stress inducible and regularly crop up in proteomic and ...
D. Dixon, R. Edwards
semanticscholar   +3 more sources

Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review

open access: yesMetabolites, 2023
Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death.
Anfal Alwan Al-Temimi   +6 more
doaj   +1 more source

Interaction of Glutathione with MMACHC Arginine-Rich Pocket Variants Associated with Cobalamin C Disease: Insights from Molecular Modeling

open access: yesBiomedicines, 2023
Methylmalonic aciduria and homocystinuria type C protein (MMACHC) is required by the body to metabolize cobalamin (Cbl). Due to its complex structure and cofactor forms, Cbl passes through an extensive series of absorptive and processing steps before ...
Priya Antony   +4 more
doaj   +1 more source

Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942. [PDF]

open access: yes, 2020
An excess of reactive oxygen species (ROS) can cause severe oxidative damage to cellular components in photosynthetic cells. Antioxidant systems, such as the glutathione (GSH) pools, regulate redox status in cells to guard against such damage ...
Beld, Joris   +9 more
core   +2 more sources

Role of Glutathione in Neutrophil Chemotaxis in Periodontitis

open access: yesOral, 2023
Periodontitis is a common non-communicable inflammatory disease that leads to the destruction of periodontal tissues and tooth loss. Initiated by the plaque biofilm, there is a strong innate immune response with an abundance of neutrophils in the ...
Nurul Iman Binti Badlishah Sham   +1 more
doaj   +1 more source

Mechanisms of Copper Tolerance, Accumulation, and Detoxification in the Marine Macroalga Ulva compressa (Chlorophyta): 20 Years of Research

open access: yesPlants, 2020
Copper induces an oxidative stress condition in the marine alga Ulva compressa that is due to the production of superoxide anions and hydrogen peroxide, mainly in organelles.
Alejandra Moenne   +5 more
doaj   +1 more source

Overexpression of CsGSH2 Alleviates Propamocarb Residues and Phytotoxicity in Cucumber by Enhancing Antioxidant and Glutathione Detoxification Properties

open access: yesAgriculture, 2022
Propamocarb is a pesticide widely used to control cucumber downy mildew. The overuse of propamocarb has resulted in residues and phytotoxicity. However, the detoxification and metabolic process of propamocarb have not been documented well.
Shengnan Li   +7 more
doaj   +1 more source

Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia

open access: yesAntioxidants, 2021
Pancreatic stellate cells (PSC) play a major role in the formation of fibrotic tissue in pancreatic tumors. On its side, melatonin is a putative therapeutic agent for pancreatic cancer and inflammation.
Matias Estaras   +12 more
doaj   +1 more source

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