Results 21 to 30 of about 971,313 (343)

Plasmodium falciparum glyoxalase II: Theorell-Chance product inhibition patterns, rate-limiting substrate binding via Arg(257)/Lys(260), and unmasking of acid-base catalysis [PDF]

, 2009
Glyoxalase II (GloII) is a ubiquitous thioester hydrolase catalyzing the last step of the glutathione-dependent conversion of 2-oxoaldehydes to 2-hydroxycarboxylic acids.
Elia A.C., Hamilton D.S., Penninckx M.J., Ridderström M., Ridderström M., Thornalley P.J., Thornalley P.J.   +6 more
core   +1 more source

Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for H2O2 and Glutathione Detection

Frontiers in Bioengineering and Biotechnology, 2022
Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body.
Ying Liu, Jianghong Yan, Yu Huang, Zhiheng Sun, Huijing Zhang, Lihaoyuan Fu, Xuwen Li, Yongri Jin   +7 more
doaj   +1 more source

Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]

, 1992
The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
B Neumcke, B Nilius, EM Fenwick, J Patlak, JB Patlak, JP Ruppersberg, M Kohlhardt, M Kohlhardt, M. Strupp, N. Mitrović, P Jonas, P. Grafe, PM Vassilev, R Stämpfli, S. Quasthoff, W Stühmer   +15 more
core   +1 more source

Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification

Metabolites, 2021
Glutathione is an essential metabolite for plant life best known for its role in the control of reactive oxygen species (ROS). Glutathione is also involved in the detoxification of methylglyoxal (MG) which, much like ROS, is produced at low levels by ...
S. Dorion, Jasmine C. Ouellet, J. Rivoal
semanticscholar   +1 more source

Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies

Journal of Ayurveda and Integrative Medicine, 2010
Triphala (TP) is composed of Emblica officinalis, Terminalia chebula, and Terminalia belerica. The present study was undertaken to evaluate its anticataract potential in vitro and in vivo in a selenite-induced experimental model of cataract.
Suresh Kumar Gupta, V Kalaiselvan, Sushma Srivastava, Shyam S Agrawal, Rohit Saxena   +4 more
doaj   +1 more source

Role of Glutathione in Cancer: From Mechanisms to Therapies

Biomolecules, 2020
Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid ...
Luke Kennedy, J. Sandhu, M. Harper, M. Čuperlović-Culf   +3 more
semanticscholar   +1 more source

Glutathione S-Transferases in Cancer

Antioxidants, 2021
In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities.
R. Singh, Katie M. Reindl
semanticscholar   +1 more source

Oxidative stress in the latissimus dorsi muscle of diabetic rats

Brazilian Journal of Medical and Biological Research, 2000
The purpose of the present study was to investigate the effects of experimental diabetes on the oxidant and antioxidant status of latissimus dorsi (LD) muscles of male Wistar rats (220 ± 5 g, N = 11).
K.L.D. De Angelis, I.A. Cestari, J. Barp, P. Dall'Ago, T.G. Fernandes, P.I. Homem de Bittencourt, A. Belló-Klein, A.A. Belló, S. Llesuy, M.C. Irigoyen   +9 more
doaj   +1 more source

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]

, 2016
Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F., Lowes, D. A., McCreath, G., Scullion, M. M. F., Webster, N. R.   +4 more
core   +1 more source

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

Frontiers in Physiology, 2019
Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated
Jaakko Hentilä, Tuuli A. Nissinen, Ayhan Korkmaz, Sanna Lensu, Mika Silvennoinen, Arja Pasternack, Olli Ritvos, Mustafa Atalay, Juha J. Hulmi, Juha J. Hulmi   +9 more
doaj   +1 more source