Results 51 to 60 of about 8,996 (206)

Hsp70 in Redox Homeostasis

Cells, 2022
Cellular redox homeostasis is precisely balanced by generation and elimination of reactive oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and DNA to damage cells but can also act as signaling molecules to modulate
Hong Zhang, Weibin Gong, Si Wu, Sarah Perrett   +3 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

GSTpi regulates VE-cadherin stabilization through promoting S-glutathionylation of Src

Redox Biology, 2020
GSTpi is a Phase II metabolic enzyme which is originally considered as an important facilitator of cellular detoxification. Here, we found that GSTpi stabilized VE-cadherin in endothelial cell membrane through inhibiting VE-cadherin phosphorylation and ...
Yang Yang, Xiaoliang Dong, Shuangning Zheng, Jinbing Sun, Juan Ye, Jiao Chen, Yuan Fang, Bing Zhao, Zhimin Yin, Peng Cao, Lan Luo   +10 more
doaj   +1 more source

Glutaredoxins Rapidly Reduce Glutathione Hydroper‐ and Polysulfides

Angewandte Chemie International Edition, EarlyView.
Glutaredoxins (Grx) rapidly reduce glutathione polysulfides (GSSnSG) to glutathione hydroper/polysulfides (GSSnH) or GSSnH to hydrogen (poly)sulfides (H2Sn). Reduction of glutathionylated glutaredoxins by reduced glutathione (GSH) yields glutathione disulfide (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

Regulation of Annexin A2 by Reversible Glutathionylation [PDF]

Journal of Biological Chemistry, 2004
The annexin A2-S100A10 heterotetramer (AIIt) is a multifunctional Ca(2+)-dependent, phospholipid-binding, and F-actin-binding phosphoprotein composed of two annexin A2 subunits and two S100A10 subunits. It was reported previously that oxidative stress from exogenous hydrogen peroxide or generated in response to tumor necrosis factor-alpha results in ...
Jennifer F, Caplan, Nolan R, Filipenko, Sandra L, Fitzpatrick, David M, Waisman   +3 more
openaire   +2 more sources

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Glutathionyl‐hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones [PDF]

FEBS Letters, 2014
Glutathionyl‐hydroquinone reductases (GHRs) catalyze the deglutathionylation of quinones via a catalytic cysteine. The two GHR genes in the Populus trichocarpa genome, Pt‐GHR1 and Pt‐GHR2, are primarily expressed in reproductive organs. Both proteins are localized in plastids. More specifically, Pt‐GHR2 localizes in nucleoids.
Lallement, Pierre-Alexandre, Meux, Edgar, Gualberto, José M., Dumarcay, Stéphane, Favier, Frédérique, Didierjean, Claude, Saul, Frederick, Haouz, Ahmed, Rouhier, Mélanie, Gelhaye, Éric, Rouhier, Nicolas, Hecker, Arnaud   +11 more
openaire   +4 more sources

Omega-Class Glutathione Transferases Protect DNA from Oxidative Stress in Pathogenic Helminth Reproductive Cells

Antioxidants, 2023
Pathogenic helminths have evolved mechanisms to preserve reproductive function while surviving long-term in the host via robust protective responses.
Jeong-Geun Kim, Insug Kang, Chun-Seob Ahn, Woon-Mok Sohn, Yoon Kong   +4 more
doaj   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Sirtuin Oxidative Post-translational Modifications

Frontiers in Physiology, 2021
Increased sirtuin deacylase activity is correlated with increased lifespan and healthspan in eukaryotes. Conversely, decreased sirtuin deacylase activity is correlated with increased susceptibility to aging-related diseases.
Kelsey S. Kalous, Sarah L. Wynia-Smith, Brian C. Smith   +2 more
doaj   +1 more source