Results 71 to 80 of about 8,445 (200)

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

New insights into posttranslational modifications of proteins during bull sperm capacitation

Cell Communication and Signaling, 2023
Background Due to the unique nature of spermatozoa, which are transcriptionally and translationally silent, the regulation of capacitation is based on the formation of posttranslational modifications of proteins (PTMs).
Agnieszka Mostek-Majewska, Anna Majewska, Anna Janta, Andrzej Ciereszko   +3 more
doaj   +1 more source

Disturbances of the Lung Glutathione System in Adult Guinea Pigs Following Neonatal Vitamin C or Cysteine Deficiency

Antioxidants, 2023
In premature infants receiving parenteral nutrition, oxidative stress is a trigger for the development of bronchopulmonary dysplasia, which is an important factor in the development of adult lung diseases. Neonatal vitamin C and glutathione deficiency is
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie   +2 more
doaj   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source

Atypical Iron-Sulfur Cluster Binding, Redox Activity and Structural Properties of Chlamydomonas reinhardtii Glutaredoxin 2

Antioxidants, 2021
Glutaredoxins (GRXs) are thioredoxin superfamily members exhibiting thiol-disulfide oxidoreductase activity and/or iron-sulfur (Fe-S) cluster binding capacities. These properties are determined by specific structural factors.
Thomas Roret, Bo Zhang, Anna Moseler, Tiphaine Dhalleine, Xing-Huang Gao, Jérémy Couturier, Stéphane D. Lemaire, Claude Didierjean, Michael K. Johnson, Nicolas Rouhier   +9 more
doaj   +1 more source

The Circadian Oscillator Affects Both Glutathione Homeostasis and Its Response to Salt Stress in Arabidopsis thaliana

Plant, Cell &Environment, Volume 49, Issue 8, Page 5421-5434, August 2026.
ABSTRACT Glutathione, including reduced glutathione (GSH) and oxidized glutathione (GSSG), is the major non‐protein thiol‐based redox buffer. There are diurnal rhythms in total glutathione level and in this work, we investigate whether these oscillations might be indicative of circadian regulation of total glutathione homeostasis.
Desiré Cano‐Yelo, Raquel López‐Martínez, Francisca Sevilla, Alex A. R. Webb, Ana Jiménez, María Carmen Martí   +5 more
wiley   +1 more source

Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling

Antioxidants, 2023
This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was designed to collect review articles and original research studies focused on advancing the current understanding of the roles of the GSH/Grx system in cellular homeostasis
Yuh-Cherng Chai, John J. Mieyal
doaj   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Functional Genomics of Sulfur Metabolism in Rice: Insights From Transgenic and MicroRNA‐Based Strategies

Plant Direct, Volume 10, Issue 7, July 2026.
ABSTRACT Sulfur (S) is an essential macronutrient that plays critical roles in plant growth, redox homeostasis, stress adaptation, and immunity. In rice (Oryza sativa), sulfur deficiency is becoming increasingly common due to modern agricultural practices, yet the molecular regulation of sulfur metabolism remains incompletely understood.
Fawad Rauf, Hakim Zamir, Hussam Ahmad, Daud Ali Shah, Shahrukh Khan, Zameer Hussain Jamali, Sada Tanzil, Mohammed S. Alotaibi, Usman Zulfiqar, Dilnoza Sotiboldiyeva, Dilshod Rakhmanov, Mayank Anand Gururani, Shakal Khan Korai   +12 more
wiley   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source