Results 81 to 90 of about 8,996 (206)

Actin polymerization and its glutathionylation are required for NET formation [PDF]

, 2016
Neutrophils are the most abundant cells in blood and their antimicrobial defense capabilities are defined, at least partially, by their formation of neutrophil extracellular traps (NETs).
Stojkov, Darko
core  

Evaluation of protein S-glutathionylation patterns.

, 2013
Evaluation of protein S-glutathionylation patterns was performed by 2D-immunoblotting with anti-GSH antibody: A) control cells. B) H-RasV12 expressing cells.
Carla Emiliani (184188), Lorena Urbanelli (293124), Francesca Magherini (293125), Giovanni Principato (293128), Alessandra Modesti (293127), Alessandro Magini (184184), Armanda Pugnaloni (293126), Francesco Piva (72402), Luisa Ercolani (293123), Tatiana Armeni (293122)   +9 more
core   +1 more source

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba, Keiko Kaihara, Hiroki Tanaka, Naoki Nakagawa, Gentaro Iribe   +4 more
wiley   +1 more source

An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet

Redox Report, 2020
Our group recently documented that male mice containing a deletion for one copy of the glutaredoxin-2 (Grx2) gene were completely protected from developing diet-induced obesity (DIO). Objectives: Here, we conducted a similar investigation but with female
Robert Gill, Sarah Mallay, Adrian Young, Ryan J. Mailloux   +3 more
doaj   +1 more source

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC–MS/MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Non‐reduced trypsin digestion of therapeutic antibodies can generate large disulfide‐linked peptide complexes that exhibit poor chromatographic and mass spectrometric performance. This limits the confident characterization of posttranslational modifications (PTMs) in specific antibody regions, such as the heavy‐chain constant region ...
Nanna Sofie Eskesen, Yann Leblanc, Justine Lempereur, Martin Ørgaard, Elizabeta Madzharova, Trine M. Sloth, Simon Krabbe, Alexandra K. Rebak, Magali André, Pernille F. Jensen, Dan B. Kristensen   +10 more
wiley   +1 more source

Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary

, 2007
BACKGROUND: Cysteinyl residues in actin are glutathionylated, ie. form a mixed disulfide with glutathione, even in the absence of exogenous oxidative stress.
Lundberg, M,, Johansson, M
core   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease

Life
Protein kinase A (PKA) is a key regulator of cellular signaling that regulates key physiological processes such as metabolism, cell proliferation, and neuronal function.
Ese S. Ekhator, Marco Fazzari, Robert H. Newman   +2 more
doaj   +1 more source

Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana

Frontiers in Plant Science, 2016
In plants triosephosphate isomerase (TPI) interconverts glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the Calvin-Benson cycle.
Laura Margarita López-Castillo, Pedro Jimenez Sandoval, Noe Baruch Torres, Carlos H Trasviña Arenas, Corina Diaz Quezada, Samuel Lara Gonzalez, Robert Winkler, Luis G Brieba   +7 more
doaj   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source