Results 81 to 90 of about 8,445 (200)

SMYD2 glutathionylation contributes to degradation of sarcomeric proteins [PDF]

Nature Communications, 2018
Abstract Reactive oxygen species (ROS) contribute to the etiology of multiple muscle-related diseases. There is emerging evidence that cellular stress can lead to destabilization of sarcomeres, the contractile unit of muscle. However, it is incompletely understood how cellular stress induces structural destabilization of sarcomeres ...
Dhanushka N. P. Munkanatta Godage, Garrett C. VanHecke, Kusal T. G. Samarasinghe, Han-Zhong Feng, Mark Hiske, Joshua Holcomb, Zhe Yang, Jian-Ping Jin, Charles S. Chung, Young-Hoon Ahn   +9 more
openaire   +3 more sources

Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells

Redox Biology, 2014
The NADPH oxidase homolog dual oxidase 1 (DUOX1) plays an important role in innate airway epithelial responses to infection or injury, but the precise molecular mechanisms are incompletely understood and the cellular redox-sensitive targets for DUOX1 ...
Milena Hristova, Carmen Veith, Aida Habibovic, Ying-Wai Lam, Bin Deng, Miklos Geiszt, Yvonne M.W. Janssen-Heininger, Albert van der Vliet   +7 more
doaj   +1 more source

Non‐triazine photosystem II inhibitors provide effective control of metabolic atrazine‐resistant Amaranthus tuberculatus

Pest Management Science, Volume 82, Issue 7, Page 6864-6876, July 2026.
Metabolism‐based atrazine‐resistant Amaranthus tuberculatus populations ACR and MCR exhibit little or no cross‐resistance to amicarbazone and metribuzin, suggesting that non‐halogenated Group 5 herbicides can be utilized to re‐establish effective control.
Alexander J Lopez, Ryan S Henry, Kip E Jacobs, Damilola A Raiyemo, Isabel S Werle, Patrick J Tranel   +5 more
wiley   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, Volume 183, Issue 13, Page 3762-3779, July 2026.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

Reversible Silencing of CFTR Chloride Channels by Glutathionylation [PDF]

The Journal of General Physiology, 2005
The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation- and ATP-dependent chloride channel that modulates salt and water transport across lung and gut epithelia. The relationship between CFTR and oxidized forms of glutathione is of potential interest because reactive glutathione species are produced in inflamed epithelia ...
Wang, Wei, Oliva, Claudia, Li, Ge, Holmgren, Arne, Lillig, Christopher Horst, Kirk, Kevin L.   +5 more
openaire   +2 more sources

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet

Redox Report, 2020
Our group recently documented that male mice containing a deletion for one copy of the glutaredoxin-2 (Grx2) gene were completely protected from developing diet-induced obesity (DIO). Objectives: Here, we conducted a similar investigation but with female
Robert Gill, Sarah Mallay, Adrian Young, Ryan J. Mailloux   +3 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, Volume 4, Issue 2, June 2026.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Redox regulation of the proteasome via S-glutathionylation

Redox Biology, 2014
The proteasome is a multimeric and multicatalytic intracellular protease responsible for the degradation of proteins involved in cell cycle control, various signaling processes, antigen presentation, and control of protein synthesis. The central catalytic complex of the proteasome is called the 20S core particle.
Marilene Demasi, Luis E.S. Netto, Gustavo M. Silva, Adrian Hand, Cristiano L.P. de Oliveira, Renata N. Bicev, Fabio Gozzo, Mario H. Barros, Janaina M.M. Leme, Erina Ohara   +9 more
openaire   +3 more sources

Actin polymerization and its glutathionylation are required for NET formation

, 2016
Neutrophils are the most abundant cells in blood and their antimicrobial defense capabilities are defined, at least partially, by their formation of neutrophil extracellular traps (NETs).
Stojkov, Darko
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