Results 91 to 100 of about 8,445 (200)

Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease

Life
Protein kinase A (PKA) is a key regulator of cellular signaling that regulates key physiological processes such as metabolism, cell proliferation, and neuronal function.
Ese S. Ekhator, Marco Fazzari, Robert H. Newman   +2 more
doaj   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics

, 2013
Uncoupling protein-2 (UCP2) is used by cells to control reactive oxygen species (ROS) production by mitochondria. This ability depends on the glutathionylation state of UCP2. UCP2 is often overexpressed in drug resistant cancer cells and therein controls
Adjeitey, Cyril Nii-Klu, Harper, Mary-Ellen, Mailloux, Ryan J., Pfefferle, Aline   +3 more
core   +1 more source

Activation of Nrf2 at Critical Windows of Development Alters Tissue-Specific Protein S-Glutathionylation in the Zebrafish (Danio rerio) Embryo

Antioxidants
Activation of Nrf2—the master regulator of antioxidative response—at different stages of embryonic development has been shown to result in changes in gene expression, but the tissue-specific and downstream effects of Nrf2 activation during development ...
Emily S. Marques, Emily G. Severance, Paige Arsenault, Sarah M. Zahn, Alicia R. Timme-Laragy   +4 more
doaj   +1 more source

Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana

Frontiers in Plant Science, 2016
In plants triosephosphate isomerase (TPI) interconverts glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the Calvin-Benson cycle.
Laura Margarita López-Castillo, Pedro Jimenez Sandoval, Noe Baruch Torres, Carlos H Trasviña Arenas, Corina Diaz Quezada, Samuel Lara Gonzalez, Robert Winkler, Luis G Brieba   +7 more
doaj   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Detection of ROS Induced Proteomic Signatures by Mass Spectrometry

Frontiers in Physiology, 2017
Reversible and irreversible post-translational modifications (PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling.
Brian McDonagh
doaj   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Microtubule S-glutathionylation as a potential approach for antimitotic agents [PDF]

, 2012
Background Microtubules have been one of the most effective targets for the development of anticancer agents. Cancer cells treated by these agents are characterized by cell arrest at G2/M phase.
Young, A., John Ruffolo, Yong Zhao, Alan Young, Xiaoying Zhang, Chen, W., Zhang, X., Xiangming Guan, Zhao, Y., Guan, X., Teresa Seefeldt, Kaushik, R.S., Wei Chen, Ruffolo, J., Radhey S Kaushik, Seefeldt, T.   +15 more
core   +1 more source

Glutathionylspermidine in the Modification of Protein SH Groups: The Enzymology and Its Application to Study Protein Glutathionylation

Molecules, 2015
Cysteine is very susceptible to reactive oxygen species. In response; posttranslational thiol modifications such as reversible disulfide bond formation have arisen as protective mechanisms against undesired in vivo cysteine oxidation.
Jason Ching-Yao Lin, Bing-Yu Chiang, Chi-Chi Chou, Tzu-Chieh Chen, Yi-Ju Chen, Yu-Ju Chen, Chun-Hung Lin   +6 more
doaj   +1 more source