Results 61 to 70 of about 8,996 (206)

Top‐Down CSF Peptidomics Reveals Disease‐Associated Peptide Signatures and Oxidative Modifications in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

PROTEOMICS, EarlyView.
ABSTRACT Multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory demyelinating diseases of the CNS whose diagnosis is mainly based on clinical evidence, magnetic resonance imaging, and the analysis of cerebrospinal fluid (CSF). Current approaches provide only partial insight into disease‐related biological processes, thus
Cristina Contini, Lorena Lorefice, Greca Lai, Alessandra Schirru, Giorgia Zodio, Tiziana Cabras, Alessandra Olianas, Giacomo Diaz, Eleonora Cocco, Barbara Manconi   +9 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

SMYD2 glutathionylation contributes to degradation of sarcomeric proteins [PDF]

Nature Communications, 2018
Abstract Reactive oxygen species (ROS) contribute to the etiology of multiple muscle-related diseases. There is emerging evidence that cellular stress can lead to destabilization of sarcomeres, the contractile unit of muscle. However, it is incompletely understood how cellular stress induces structural destabilization of sarcomeres ...
Dhanushka N. P. Munkanatta Godage, Garrett C. VanHecke, Kusal T. G. Samarasinghe, Han-Zhong Feng, Mark Hiske, Joshua Holcomb, Zhe Yang, Jian-Ping Jin, Charles S. Chung, Young-Hoon Ahn   +9 more
openaire   +3 more sources

A Comparison of Reversible Versus Irreversible Protein Glutathionylation

, 2014
Glutathionylation is generally a reversible posttranslational modification that occurs to cysteine residues that have been exposed to reactive oxygen species (P-SSG).
Arthur J.L. Cooper, Townsend, Danyelle, Volodymyr I. Lushchak, Cooper, Arthur J, Townsend, Danyelle M, Lushchak, Volodymyr I, Cooper, Arthur J L, Danyelle M. Townsend   +7 more
core   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases

Antioxidants, 2022
Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease. One of the major enzyme systems involved in the defense against reactive oxygen species are the tripeptide glutathione and oxidoreductase glutaredoxin.
Haseena P. A., Latha Diwakar, Vijayalakshmi Ravindranath   +2 more
openaire   +3 more sources

Plasticity in plastid redox networks: evolution of glutathione-dependent redox cascades and glutathionylation sites

BMC Plant Biology, 2021
Background Flexibility of plant metabolism is supported by redox regulation of enzymes via posttranslational modification of cysteine residues, especially in plastids.
Stefanie J. Müller-Schüssele, Finja Bohle, Jacopo Rossi, Paolo Trost, Andreas J. Meyer, Mirko Zaffagnini   +5 more
doaj   +1 more source

Disturbances of the Lung Glutathione System in Adult Guinea Pigs Following Neonatal Vitamin C or Cysteine Deficiency

Antioxidants, 2023
In premature infants receiving parenteral nutrition, oxidative stress is a trigger for the development of bronchopulmonary dysplasia, which is an important factor in the development of adult lung diseases. Neonatal vitamin C and glutathione deficiency is
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie   +2 more
doaj   +1 more source

S‑glutathionylation of MaWRKY44 orchestrates a MaZFP139‐MaWRKY44‐MaGSTU07 cascade to enhance banana cold tolerance

Journal of Integrative Plant Biology, EarlyView.
In banana, at low temperatures (7°C), the transcription factor MaZFP139 activates MaWRKY44 expression. MaWRKY44 binds to the W‐box sites in the promoter of the glutathione S‐transferase gene MaGSTU07 to enhance reactive oxygen species scavenging. S‐glutathionylation protects MaWRKY44 from oxidation‐induced degradation, reinforcing antioxidant defenses ...
Shuqin Lin, Wen Song, Shaoting Liao, Haike Tan, Jianji Qi, Danling Cai, Wei Wei, Wei Shan, Jianfei Kuang, Jianye Chen, Wangjin Lu   +10 more
wiley   +1 more source

Protein-Protein Interaction between Glyoxalase II and Specific Redox Dependent Proteins through S-Glutathionylation Modification

, 2020
S-glutathionylation, the reversible formation of a mixed disulfide bridge between a specific cysteine and a glutathione molecule, can occur spontaneously or be catalyzed by enzymes. Glyoxalase II (GloII), using its natural substrate SLG can form specific
Andrea Scirè, Tatiana Armeni, Laura Cianfruglia, Cristina Minnelli   +3 more
core   +1 more source