Results 1 to 10 of about 134,228 (341)

Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice. [PDF]

Adipocyte
Du Z, Wu J, Zhang T, Ma X, Li Z, Xu J, You J, Chen N, Wu J.   +8 more
europepmc   +2 more sources

Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development

Cells, 2022
Type 1 diabetes (T1D) is an autoimmune disease in which the β-cells of the pancreas are attacked by the host’s immune system, ultimately resulting in hyperglycemia. It is a complex multifactorial disease postulated to result from a combination of genetic
Chenping Du, Rani O. Whiddett, Irina Buckle, Chen Chen, Josephine M. Forbes, Amelia K. Fotheringham   +5 more
doaj   +1 more source

Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat

Antioxidants, 2021
Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation.
Reyna Rodríguez-Mortera, Russell Caccavello, Ricardo Hermo, María Eugenia Garay-Sevilla, Alejandro Gugliucci   +4 more
doaj   +1 more source

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Endocrinology, Diabetes & Metabolism, 2021
Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐protective in ...
Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes   +10 more
doaj   +1 more source

Biophysical Characterisation of Amadori Modified Human Serum Albumin: A Prognostic Biomarker for Diabetic Complications [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Glycation of biological macromolecules particularly protein leads to the generation of early and Advanced Glycation End (AGE) products. The interest in early glycation of protein is driven due to the fact of Amadori modified proteins having
Binish Arif, Zubair Ahmad, Gulzar Ahmad Bhat, Syed Mudassar, Khursheed Aalam   +4 more
doaj   +1 more source

Effect of transferrin glycation induced by high glucose on HK-2 cells in vitro

Frontiers in Endocrinology, 2023
Background and objectiveGlycation is a common post-transcriptional modification of proteins. Previous studies have shown that advanced glycation end modified transferrin (AGE-Tf) levels in diabetic rat kidney tissues were increased; however, its role in ...
Yanqi Ma, Qikai Zhou, Pingping Zhao, Xiaoyu Lv, Caixia Gong, Jie Gao, Jingfang Liu, Jingfang Liu   +7 more
doaj   +1 more source

Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes

Scientific Reports, 2023
Hypoglycemia in type 1 diabetes associates with changes in the pancreatic islet α cells, where the receptor for advanced glycation end products (RAGE) is highly expressed.
Sherman S. Leung, Nataliya Lenchik, Clayton Mathews, Alberto Pugliese, Domenica A. McCarthy, Selena Le Bagge, Adam Ewing, Mark Harris, Kristen J. Radford, Danielle J. Borg, Ivan Gerling, Josephine M. Forbes   +11 more
doaj   +1 more source

Glycated Tryptophan PHP-THβC Incorporated into Various Chicken Embryonic Cells Constitutes Cellular Proteins

The Journal of Poultry Science, 2021
Glycation is a non-enzymatic reaction, and amino acids are glycated by glucose in vivo. Tryptophan is glycated with glucose to form two types of glycated compounds, tryptophan-Amadori product and (1R, 3S)-1-(D-gluco-1, 2, 3, 4, 5-pentahydroxypentyl)-1, 2,
Ryosuke Makino, Kayoko Abe, Kazumi Kita
doaj   +1 more source

Carbonyl Stress in Red Blood Cells and Hemoglobin

Antioxidants, 2021
The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to reactive carbonyl compounds (RCC) from both blood plasma and the intracellular
Olga V. Kosmachevskaya, Natalia N. Novikova, Alexey F. Topunov   +2 more
doaj   +1 more source

Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

Antioxidants, 2019
High density lipoproteins (HDL) structure and function studies are needed to better understand the heterogeneous nature of the HDL particle, and its interaction with associated proteins such as apolipoprotein A-1 (ApoA-1), paraoxonase 1 (PON1) and the ...
Yasmin Bains, Russell Caccavello, Kazuhiko Kotani, Alejandro Gugliucci   +3 more
doaj   +1 more source