Results 21 to 30 of about 4,588 (217)

An Electrochemical Chip to Monitor In Vitro Glycation of Proteins and Screening of Antiglycation Potential of Drugs

open access: yesPharmaceutics, 2020
Hyperglycemia and the production of advanced glycation end products (AGEs) are the primary factors for the development of chronic complications in diabetes.
Zeeshan A. Khan, Seungkyung Park
doaj   +1 more source

Influence of Lactose on the Maillard Reaction and Dehydroalanine-Mediated Protein Cross-Linking in Casein and Whey

open access: yesFoods, 2022
A liquid chromatography–mass spectrometry method based on multiple reaction monitoring (MRM) was developed for the simultaneous quantification of markers representing two potentially competing pathways, the Maillard reaction and the dehydroalanine ...
Søren D. Nielsen   +4 more
doaj   +1 more source

DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein

open access: yesBiomolecules, 2021
Glycation of α-synuclein (αSyn), as occurs with aging, has been linked to the progression of Parkinson’s disease (PD) through the promotion of advanced glycation end-products and the formation of toxic oligomers that cannot be properly cleared from ...
Tamr B. Atieh   +4 more
doaj   +1 more source

Increased Non-Enzymatic Glycation of Plasma Proteins and Hemoglobin in Non-Diabetic Patients with Acute Myocardial Infarction (MI) [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2013
Background: Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute ...
V. Parthibane   +4 more
doaj   +1 more source

Proteomic Investigation of Glyceraldehyde-Derived Intracellular AGEs and Their Potential Influence on Pancreatic Ductal Cells

open access: yesCells, 2021
Glyceraldehyde-derived advanced glycation end products (AGEs) play an important role in the pathogenesis of many diseases including cancer. Accumulation of intracellular AGEs could stimulate cancer induction and facilitate cancer progression.
Lakmini Senavirathna   +3 more
doaj   +1 more source

Behavior of Regular Insulin in a Parenteral Nutrition Admixture: Validation of an LC/MS-MS Assay and the In Vitro Evaluation of Insulin Glycation

open access: yesPharmaceutics, 2022
Parenteral-nutrition (PN)-induced hyperglycemia increases morbidity and mortality and must be treated with insulin. Unfortunately, the addition of insulin to a ternary PN admixture leads to a rapid decrease in insulin content.
Heloise Henry   +7 more
doaj   +1 more source

Half-life of Glycated Tryptophan in the Plasma of Chickens

open access: yesThe Journal of Poultry Science, 2018
Tryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily
Ryosuke Makino, Kazumi Kita
doaj   +1 more source

Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

open access: yesMolecules, 2014
The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to
Izabela Sadowska-Bartosz   +2 more
doaj   +1 more source

Failure of Common Glycation Assays to Detect Glycation by Fructose

open access: yesClinical Chemistry, 1992
Abstract Serum albumin was modified by in vitro glycation with either fructose or glucose, to see whether the common clinical assays for glycation were able to detect both fructose- and glucose-induced changes in protein structure in diabetes.
N, Ahmed, A J, Furth
openaire   +2 more sources

Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High‐Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non‐Invasive Diabetes Monitoring

open access: yesAdvanced Healthcare Materials, EarlyView.
An AuNPs/fMWCNT nanocomposite‐modified screen‐printed carbon electrode was engineered via sequential electrodeposition and integrated into a 3D‐printed microfluidic platform for ultrasensitive methylglyoxal detection. The non‐invasive sensing platform enables rapid analysis in saliva and sweat, highlighting strong potential for wearable point‐of‐care ...
Ahadul Amin Soshi   +3 more
wiley   +1 more source

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