Results 221 to 230 of about 979,308 (296)

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

Tuning the hydrophobicity of glycine ester through <i>N</i>-acylation and introducing quaternary pyridinium groups enable the selectivity against Gram-positive bacteria. [PDF]

RSC Adv
Pious A, Singaravelu DK, Srikanth S, Ulaganathan V, Sivanandan C, Alown F, Ameen F, Veerappan A.   +7 more
europepmc   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Glycine Composition and Ion Valency Tune Phase Behavior and Drug Encapsulation in Designer Peptide Condensates. [PDF]

ACS Appl Mater Interfaces
Veretnik S, Harris R, Lampel A.
europepmc   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Computational Repurposing and Experimental Validation of YBX1 Inhibitors in Hepatocellular Carcinoma. [PDF]

Biomedicines
Karkoutly O, Nagati V, Chauhan SC, Tripathi M.   +3 more
europepmc   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, EarlyView.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Multiple formation pathways for amino acids in the early Solar System based on carbon and nitrogen isotopes in asteroid Bennu samples. [PDF]

Proc Natl Acad Sci U S A
Baczynski AA, Mcintosh OM, Simkus DN, McLain HL, Dworkin JP, Glavin DP, Elsila JE, Matney M, House CH, Freeman KH, Connolly HC, Lauretta DS.   +11 more
europepmc   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. [PDF]

Mol Pharmacol
Benton AJ, Johns MR, Diamant E, Rouzbeh N, Sørensen VP, Anderson CM, Secci D, Zhang Z, Rau AR, Clausen RP, Hansen KB.   +10 more
europepmc   +1 more source