Results 231 to 240 of about 979,308 (296)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects. [PDF]

Nat Commun
Cantwell Chater RP, Peiser-Oliver J, Pati TK, Quinn AS, Lotsaris I, Frangos ZJ, Anderson KE, Tischer AE, Williams-Noonan BJ, Aubrey KR, O'Mara ML, Michaelides M, Mohammadi SA, Cioffi CL, Vandenberg RJ, Shahsavar A.   +15 more
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Backbone nitrogen substitution restricts the conformation of glycine residues in β-turns. [PDF]

Chem Commun (Camb)
Gu F, Thomas D, Newberry RW.
europepmc   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Glycine photosynthesis via C-N coupling of waste plastic and nitrate over diatomic Pd-B catalyst. [PDF]

Nat Commun
Ya Z, Li M, Fu D, Zheng Y, Wei R, Wang H, Zhang K, Xu D, Zhang Z, Zhang X, Yan S, Wang H, Zhang S, Gong J.   +13 more
europepmc   +1 more source

Correction to "Presynaptic Glycine Receptors Increase Glutamatergic Neurotransmission in Rat Periaqueductal Gray Neurons". [PDF]

Neural Plast
europepmc   +1 more source

Biosynthesis of Glycine from One-Carbon Resources Using an Engineered Escherichia coli Whole-Cell Catalyst. [PDF]

Microorganisms
Fu M, Shi H, Bai X, Gao Q, Liu F, Li D, Kan Y, Xue C, Yao L, Tang C.   +9 more
europepmc   +1 more source

Genome-wide analysis and functional characterization of the <i>SUT</i> gene family associated with stress tolerance in <i>Glycine max</i>. [PDF]

Front Plant Sci
Cui T, He R, Wang P, Zhu Z, Xing H, Zhao J, Guo N.   +6 more
europepmc   +1 more source

Gold Nanocluster-Amino Acid Interactions: Assessment of DFTB with Dispersion Corrections. [PDF]

ACS Omega
Morehouse J, McPhee A, Howie E, L Oliveira LF.   +3 more
europepmc   +1 more source