Results 1 to 10 of about 2,731,322 (279)
Glycine receptors and brain development [PDF]
Frontiers in Cellular Neuroscience, 2013 Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult.
Ariel eAvila +6 more
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Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway [PDF]
Journal of Neuroinflammation, 2020 Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas +4 more
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Inhibitory Glycine Receptors: An Update* [PDF]
Journal of Biological Chemistry, 2012 Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites,
S. Dutertre, C. Becker, H. Betz
semanticscholar +6 more sources
Frontiers in Molecular Neuroscience, 2016 NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li +15 more
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Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors [PDF]
BMC Neuroscience, 2009 Background N-methyl-D-aspartate receptors (NMDARs) are the most complex of ionotropic glutamate receptors (iGluRs). Subunits of this subfamily assemble into heteromers, which – depending on the subunit combination – may display very different ...
Orth Angela +2 more
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Neural Plasticity, 2013 The periaqueductal gray (PAG) is involved in the central regulation of nociceptive transmission by affecting the descending inhibitory pathway. In the present study, we have addressed the functional role of presynaptic glycine receptors in spontaneous ...
Kwi-Hyung Choi +2 more
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Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
Nature Communications, 2018 Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional ...
Teddy Grand +4 more
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A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate [PDF]
BMC Neuroscience, 2010 Background Rhythmic motor patterns for locomotion in vertebrates are generated in spinal cord neural networks known as spinal Central Pattern Generators (CPGs).
Okamura Yasushi +3 more
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Frontiers in Molecular Neuroscience, 2018 Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the central nervous system (CNS). These neurotransmitters target glycine and GABAA receptors, respectively, which both belong to the Cys-loop superfamily of pentameric ...
Vikram B. Kasaragod, Hermann Schindelin
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Journal of Pharmacological Sciences, 2010 Recent evidence indicates that strychnine-sensitive glycine receptors are located in upper brain regions including the hippocampus. Because of excitatory effects of glycine via facilitation of NMDA-receptor function, however, the net effects of increased
Mitsuo Tanabe, Azusa Nitta, Hideki Ono
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