Architecture and assembly mechanism of native glycine receptors [PDF]
Nature, 2021 Hongtao Zhu, Eric Gouaux
exaly +3 more sources
Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies [PDF]
Pharmacol Rev, 2022 Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout the mammalian spinal cord, brainstem, and higher brain regions.
Casey I. Gallagher +3 more
semanticscholar +2 more sources
Glycine Receptors in Spinal Nociceptive Control—An Update [PDF]
Biomolecules, 2021 Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain states. Restoring proper synaptic inhibition is a well-established rational therapeutic approach explored by several pharmaceutical companies.
H. Zeilhofer +3 more
semanticscholar +2 more sources
Functional modulation of glycine receptors by the alkaloid gelsemine [PDF]
Br J Pharmacol, 2016 César O. Lara +12 more
semanticscholar +3 more sources
Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes [PDF]
Computational and Structural Biotechnology JournalThe relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom +9 more
doaj +2 more sources
Frontiers in Psychiatry, 2011 Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö +4 more
doaj +2 more sources
Allosteric modulation of glycine receptors
British journal of pharmacology, 2011 Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion-selective transmitter-gated ion channels of the cys-loop superfamily, which includes among others also the inhibitory γ-aminobutyric acid receptors (GABA(A) receptors). While GABA mediates fast inhibitory neurotransmission throughout the CNS, the action of glycine as a fast ...
Gonzalo E Yévenes, H. Zeilhofer
semanticscholar +4 more sources
Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons [PDF]
Frontiers in Molecular Neuroscience, 2018 Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico–striato–thalamic loop, responsible for the initiation of voluntary movements and motor learning.
Svetlana M. Molchanova +10 more
doaj +2 more sources
Glycine receptors and glycine transporters: targets for novel analgesics? [PDF]
Cell Mol Life Sci, 2017 H. Zeilhofer +3 more
semanticscholar +2 more sources
Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors [PDF]
Mol Pharmacol, 2016 C. F. Burgos +2 more
semanticscholar +2 more sources