Results 81 to 90 of about 43,679 (304)
Surface charge, glycocalyx, and blood-brain barrier function
Tissue Barriers, 2021 The negative surface charge of brain microvessel endothelial cells is derived from the special composition of their membrane lipids and the thick endothelial surface glycocalyx. They are important elements of the unique defense systems of the blood–brain
F. Walter +5 more
semanticscholar +1 more source
Absence of the Epithelial Glycocalyx As Potential Tumor Marker for the Early Detection of Colorectal Cancer. [PDF]
PLoS ONE, 2016 Detection of cancer at an early stage is pivotal for successful treatment and long term survival, yet early diagnosis requires sensitive and specific markers that can be easily detected by screening procedures.
Katrin Ramaker +7 more
doaj +1 more source
Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]
, 2016 The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L. +2 more
core +2 more sources
The significance of glycocalyx in medicine
European Journal of Clinical and Experimental Medicine, 2021 Introduction. The glycocalyx is a gel-like layer covering the membrane of many cells, especially cells of epithelial tissue. It consists of membrane-bound proteoglycans, glycosaminoglycan chains, glycoproteins, and adjacent proteins. Glycocalyx is necessary in maintaining the permeability of vessels, modulation of inflammatory responses and ...
Jakub Wawrzkowicz +5 more
openaire +2 more sources
Communications Biology, 2021 The glycocalyx on tumor cells has been recently identified as an important driver for cancer progression, possibly providing critical opportunities for treatment.
G. Offeddu +6 more
semanticscholar +1 more source
The Role of Plasma Transfusion in Massive Bleeding: Protecting the Endothelial Glycocalyx?
Frontiers in Medicine, 2018 Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients.
Stefano Barelli +2 more
doaj +1 more source
A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. [PDF]
, 2017 Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in ...
Barnes, J Matthew +7 more
core +2 more sources
Immunoengineering can overcome the glycocalyx armour of cancer cells.
Nature MaterialsCancer cell glycocalyx is a major line of defence against immune surveillance. However, how specific physical properties of the glycocalyx are regulated on a molecular level, contribute to immune evasion and may be overcome through immunoengineering must
Sangwoo Park +18 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput +5 more
wiley +1 more source
Endothelial glycocalyx: Role in body fluid homeostasis and fluid management [PDF]
, 2019 Endothelial glycocalyx layer (EGL) coating the luminal surface of vascular endothelium plays an essential role in maintaining the normal fluid homeostasis of the body.
Goswami, Shreya, Kundra, Pankaj
core +2 more sources