Results 71 to 80 of about 6,575 (136)

Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction

, 2023
Advanced age is accompanied by arterial dysfunction, as well as a diminished glycocalyx, which may be linked to reduced high molecular weight-hyaluronan (HMW-HA) synthesis.
Lesniewski, L.A., Bloom, S.I., Machin, D.R., Islam, M.T., Donato, A.J., Trott, D.W., Vink, H., Gogulamudi, V.R., Venkateswara R. Gogulamudi, Samuel I. Bloom, Anthony J. Donato, Lisa A. Lesniewski, Hans Vink, Md. Torikul Islam, Daniel W. Trott, Daniel R. Machin   +15 more
core   +1 more source

Basal endothelial glycocalyx’s response to shear stress: a review of structure, function, and clinical implications

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the
Zoe Vittum, Samantha Cocchiaro, Solomon A. Mensah, Solomon A. Mensah   +3 more
doaj   +1 more source

Sublingual endothelial glycocalyx and atherosclerosis. A cross-sectional study.

PLoS ONE, 2019
BACKGROUND:Damage to endothelial glycocalyx is thought to be an early marker of atherosclerosis and measuring reduced glycocalyx size clinically via the Perfused Boundary Region (PBR) may allow early detection of cardiovascular disease. However, the true
Luca Valerio, Ron J Peters, Aeilko H Zwinderman, Sara-Joan Pinto-Sietsma   +3 more
doaj   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Table1_Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation.docx

, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jun Zhang (48506), Jin Lei (7294613), Tingting Wang (123983), Le Chen (1446445), Lei Zhang (38117), Peng Xiang (2360800), Wanping Zhang (12036743), Issa Issoufou Ibrahim (10658516), Shengmei Zeng (12036740), Limei Ma (438710), Chao Yu (562804), Ruihong Yu (10678476), Zhiyi Yuan (9198904)   +12 more
core   +1 more source

The Earliest Feathers from the Lower Cretaceous Dabeigou Formation of North Hebei: Implications for the Early Evolution of the Jehol Biota

Integrative Zoology, EarlyView.
This study reports two isolated feather fossils from the Lower Cretaceous Dabeigou Formation in northeastern China. Morphological analyses identified them as the earliest known feathered theropods (potentially including avian) in the Jehol Biota. This finding reveals a complex ecosystem at the dawn of the Jehol Biota, bridging the temporal and faunal ...
Qian Wu, Qian‐Nan Zhang, Dang‐Peng Xi   +2 more
wiley   +1 more source

Potential nutritional and pharmacological treatment of glycocalyx alterations during sepsis

, 2023
During sepsis, a combination of pathophysiological insults disrupts the glycocalyx. the thickness of the glycocalyx is correlated with parameters of disease severity, making it a potential new and independent target for therapeutic strategies in sepsis ...
Frznchi F., Preiser J. -C., Scolletta S., Pergolizzi C., Taccone F. S.   +4 more
core   +1 more source

Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines

Annals of Intensive Care
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional
Toshiaki Iba, Cheryl L. Maier, Julie Helms, Ricard Ferrer, Jecko Thachil, Jerrold H. Levy   +5 more
doaj   +1 more source

Bulky glycocalyx shields cancer cells from invasion-associated stresses

Translational Oncology
The glycocalyx—that forms a protective barrier around cells—has been implicated in cancer cell proliferation, survival, and metastasis. However, its role in maintaining the integrity of DNA/nucleus during migration through dense matrices remains ...
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen   +3 more
doaj   +1 more source

ZAN, IZUMO1, and TMEM95 Protein Domains Identify the Physiological Status of the Sperm

Andrology, EarlyView.
ABSTRACT Background Infertility is a growing concern, which has led to an increase in the use of assisted reproductive techniques, involving in vitro sperm capacitation. Nonetheless, the optimal capacitation time remains a matter of debate, and it is unknown whether it has an impact on the localization of key membrane proteins.
Miranda Hernández‐Falcó, Paula Sáez‐Espinosa, Alejandro Romero, Andrea López‐Botella, Laura Robles‐Gómez, María José Gómez‐Torres   +5 more
wiley   +1 more source