Incorporation of phosphate into glycogen by glycogen synthase [PDF]
Archives of Biochemistry and Biophysics, 2016 The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues.
Chikwana, Vimbai M. +7 more
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Mechanism of glycogen synthase inactivation and interaction with glycogenin [PDF]
Nature Communications, 2022 Glycogen is a major energy reserve in eukaryotes and is synthesised in part by glycogenin (GN) and glycogen synthase (GS). Here, authors describe the structural basis of GS regulation, specifically the mechanism of inactivation by phosphorylation.
Laura Marr +13 more
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Molecular Therapy: Nucleic Acids, 2014 Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles.
Nicholas P Clayton +9 more
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The Hysteretic Properties of Glycogen Synthase I [PDF]
European Journal of Biochemistry, 1977 Glycogen‐free synthase I from human polymorphonuclear leukocytes is activated by its own substrate, glycogen, in a slow, time‐dependent proces (hysteretic activation). This lag in response to addition of glycogen depends on the concentration of glycogen, pH and temperature.
Henrik Sølling, Viggo Esmann
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Glycogen synthase activity in Candida albicans is partly controlled by the functional ortholog of Saccharomyces cerevisiae Gac1p [PDF]
mSphereTo adapt to various host microenvironments, the human fungal pathogen Candida albicans possesses the capacity to accumulate and store glycogen as an internal carbohydrate source.
Jian Miao +3 more
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A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis. [PDF]
PLoS Computational Biology, 2011 Timely, and sometimes rapid, metabolic adaptation to changes in food supply is critical for survival as an organism moves from the fasted to the fed state, and vice versa.
Ke Xu +4 more
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Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β [PDF]
Mediators of Inflammation, 2012 This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and ...
Liang Luo +6 more
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Glycogen metabolic genes are involved in trehalose-6-phosphate synthase-mediated regulation of pathogenicity by the rice blast fungus Magnaporthe oryzae. [PDF]
PLoS Pathogens, 2013 The filamentous fungus Magnaporthe oryzae is the causal agent of rice blast disease. Here we show that glycogen metabolic genes play an important role in plant infection by M. oryzae.
Muhammad Badaruddin +5 more
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Structural basis for 2′-phosphate incorporation into glycogen by glycogen synthase [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Glycogen is a branched glucose polymer found in most animals, fungi, bacteria, and archaea as an osmotically neutral means of energy storage. Glycogen also contains minor amounts of phosphate which can be removed by a dual specificity phosphatase, laforin.
V. Chikwana +7 more
semanticscholar +4 more sources
The inactivation of glycogen phosphorylase is not a prerequisite for the activation of liver glycogen synthase [PDF]
FEBS Letters, 1979 Carlos J. Ciudad +2 more
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