Incorporation of phosphate into glycogen by glycogen synthase [PDF]
Archives of Biochemistry and Biophysics, 2016 The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues. In the absence of the laforin phosphatase, as in the rare childhood epilepsy Lafora disease, the phosphorylation level is elevated and is associated with abnormal glycogen structure that ...
Christopher J. Contreras +7 more
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Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in mice [PDF]
Journal of Lipid ResearchMetabolic dysfunction-associated steatotic liver disease (MASLD) has become highly prevalent worldwide, largely as a consequence of the global obesity epidemic.
Liangkui Li +3 more
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Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. [PDF]
PLoS Biology, 2013 Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells.
Jonathan Zirin +2 more
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Glycogen synthase activity in Candida albicans is partly controlled by the functional ortholog of Saccharomyces cerevisiae Gac1p [PDF]
mSphereTo adapt to various host microenvironments, the human fungal pathogen Candida albicans possesses the capacity to accumulate and store glycogen as an internal carbohydrate source.
Jian Miao +3 more
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Glycogen synthase GYS1 overactivation contributes to glycogen insolubility and malto-oligoglucan-associated neurodegenerative disease [PDF]
The EMBO JournalPolyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative diseases including Lafora disease and adult polyglucosan ...
Silvia Nitschke +12 more
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Intermittent Fasting Modulates the Glycogen Level in Zebrafish (Danio rerio) and their Next Generation [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Zebrafish (Danio rerio) has become the best model organism to study the evolutionary biological process and human developmental studies.
ShanmugaSundaram Tamilarasan +2 more
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Glycogen Synthase Kinase‐3 [PDF]
International Journal of Alzheimer’s Disease, 2011 Glycogen synthase kinase-3 (GSK3) is a ubiquitous and promiscuous kinase that has been studied extensively for over four decades. Initial reports beginning in the 1970s described its role in cellular metabolic pathways fundamental to glucose metabolism, but in more recent years the number of reports describing aberrant GSK3 activity in pathological ...
Crouch, P +4 more
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Apoptosis, Cell Growth, and Glycogen Synthase Kinase 3β Phosphorylation in Caffeic Acid-Treated Human Malignant Melanoma Cells. [PDF]
BiomedicinesLee YJ +8 more
europepmc +3 more sources
Gsk-3$ \beta $ aggravates depression symptoms in a chronic stress mouse model [PDF]
Journal of Integrative Neuroscience, 2018 Depression caused by genetic and environmental factors is acomplicated disease. Here, it is demonstrated that glycogen synthase kinase-3$\beta$ is highly expressed and phosphorylated in the brain of a chronic stress mouse. Inhibition of glycogen synthase
Hong Peng, Hong-bin Wang, Ling Wang, Bing Zhou, Xiao-yong Li, Jian Tan
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Biology, 2021 Glycogen synthase kinase-3 beta is a ubiquitously and constitutively expressed molecule with pleiotropic function. It acts as a protooncogene in the development of several solid tumors including pancreatic cancer through its involvement in various ...
Robin Park +3 more
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