Marine medicinal glycomics [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Glycomics is an international initiative aimed to understand the structure and function of the glycans from a given type of cell, tissue, organism, kingdom or even environment, as found under certain conditions.
Vitor Hugo Pomin
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Compositional data analysis enables statistical rigor in comparative glycomics [PDF]
Nature CommunicationsComparative glycomics data are compositional data, where measured glycans are parts of a whole, indicated by relative abundances. Applying traditional statistical analyses to these data often results in misleading conclusions, such as spurious “decreases”
Alexander R. Bennett +4 more
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Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method [PDF]
BBA AdvancesAll eukaryotic cell surfaces are coated with various types of glycans, which are essential molecules in biological events. In this review, we summarize recent integrated glycomics studies using various biological samples.
Masaki Kurogochi +3 more
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Toward spatial glycomics and glycoproteomics: Innovations and applications [PDF]
BBA AdvancesIn this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun +2 more
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Advancement in Clinical Glycomics and Glycoproteomics for Congenital Disorders of Glycosylation: Progress and Challenges Ahead [PDF]
BiomedicinesAbu Bakar N, Hamzan N.
europepmc +2 more sources
Introduction to a special issue, “Expanded glycomics: A bridge over future glycomics” [PDF]
BBA AdvancesJun Hirabayashi, Yann Guerardel
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Nature Communications, 2023 Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8 ...
Victoria Ozberk +13 more
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Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines
Scientific Reports, 2021 We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2).
Simone Reynolds +7 more
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Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis
Nature Communications, 2021 Glycomics can uncover important molecular changes but measured glycans are highly interconnected and incompatible with common statistical methods, introducing pitfalls during analysis. Here, the authors develop an approach to identify glycan dependencies
Bokan Bao +9 more
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Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin
Pharmaceuticals, 2021 Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi +6 more
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