Results 41 to 50 of about 16,721 (247)

Leveraging glycomics data in glycoprotein 3D structure validation with Privateer

Beilstein Journal of Organic Chemistry, 2020
The heterogeneity, mobility and complexity of glycans in glycoproteins have been, and currently remain, significant challenges in structural biology. These aspects present unique problems to the two most prolific techniques: X-ray crystallography and ...
Haroldas Bagdonas, Daniel Ungar, Jon Agirre   +2 more
doaj   +1 more source

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

mBio, 2021
SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings   +9 more
doaj   +1 more source

N-Glycomics of Human Erythrocytes [PDF]

International Journal of Molecular Sciences, 2021
Glycosylation is a complex post-translational modification that conveys functional diversity to glycoconjugates. Cell surface glycosylation mediates several biological activities such as induction of intracellular signaling pathway and pathogen recognition.
Rosaria Ornella Bua, Angela Messina, Luisa Sturiale, Rita Barone, Domenico Garozzo, Angelo Palmigiano   +5 more
openaire   +5 more sources

Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]

, 2010
At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick, Lasanajak, Yi, Proost, Paul, Rouge, Pierre, Schouppe, Dieter, Smith, David F, Van Damme, Els   +6 more
core   +2 more sources

The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design

Scientific Reports, 2017
Human parainfluenza viruses represent a leading cause of lower respiratory tract disease in children, with currently no available approved drug or vaccine.
Larissa Dirr, Ibrahim M. El-Deeb, Leonard M. G. Chavas, Patrice Guillon, Mark von Itzstein   +4 more
doaj   +1 more source

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. [PDF]

, 2014
An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity.
An, Hyun Joo, Bereuter, Thomas L, Dimapasoc, Lauren, Garrido, Daniel, Grimm, Rudolf, Kim, Bum Jin, Kim, Jae-Han, Lebrilla, Carlito B, Mills, David A, Ozcan, Sureyya, Reiter, Christian, Ro, Grace   +11 more
core   +1 more source

Loss of Effector Function of Human Cytolytic T Lymphocytes Is Accompanied by Major Alterations in N- and O-Glycosylation [PDF]

, 2012
Most human tumors are not eliminated by the immune system, and therapeutic vaccination shows poor results, a fact that can be explained at least partially by an immunosuppressive tumor microenvironment that is abundant in galectin-3.
Ahmad, Antonopoulos, Barber, Boon, Ceroni, Chen, Clevers, Comelli, Cummings, Dam, Daniels, Demetriou, Demotte, Demotte, Earl, Friedl, Fukuda, Harlin, Hirabayashi, Irles, Jang-Lee, Joo, Kuball, Leppänen, Liu, Lobsanov, Merry, Moody, Moody, Nakagawa, Nika, Pace, Piller, Rabinovich, Sato, Stowell, Togayachi, Van den Hove, Wang, Wieërs, Zippelius   +40 more
core   +1 more source

Glycomics

, 2011
Paramount to our understanding of carbohydrates in biology has been the development of methods for analyzing and characterizing the essential features of glycans. This has resulted in a comprehensive appreciation for the various roles of glycans and the pathways associated with their synthesis.
Cosgrave, E.F.J., Struwe, Weston B., Kattla, J.J., Campbell, Matthew P., Wormald, M.R., Rudd, P.   +5 more
openaire   +3 more sources

Role of ammonia for brain abnormal protein glycosylation during the development of hepatitis B virus-related liver diseases

Cell & Bioscience, 2022
Background Ammonia is the most typical neurotoxin in hepatic encephalopathy (HE), but the underlying pathophysiology between ammonia and aberrant glycosylation in HE remains unknown.
Jiajun Yang, Mengqi Yin, Yao Hou, Hao Li, Yonghong Guo, Hanjie Yu, Kun Zhang, Chen Zhang, Liyuan Jia, Fan Zhang, Xia Li, Huijie Bian, Zheng Li   +12 more
doaj   +1 more source

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]

, 2013
The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M, Chen, X, Cotmore, S, Cummings, RD, Dell, A, Halder, S, Haslam, SM, Heimburg-Molinaro, J, McKenna, R, North, SJ, Smith, DF, Tattersall, P, Trollope, AJ   +12 more
core   +1 more source