Results 61 to 70 of about 16,721 (247)

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

A Holistic 4D Approach to Optimize Intrinsic and Extrinsic Factors Contributing to Variability in Microarray Biosensing in Glycomics

Sensors, 2023
Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner ...
Paras H. Kundalia, Lucia Pažitná, Kristína Kianičková, Eduard Jáné, Lenka Lorencová, Jaroslav Katrlík   +5 more
doaj   +1 more source

The potential of glycomics as prognostic biomarkers in liver disease and liver transplantation [PDF]

, 2019
The study of glycomics is a novel and fascinating approach for the development of biomarkers. It has become clear that in the field of liver disease specific glycomic patters are present in specific disease states, which has led to the development of ...
Callewaert, Nico, Geerts, Anja, Van Vlierberghe, Hans, Verhelst, Xavier   +3 more
core  

Optimisation of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis [PDF]

, 2011
Lectin’s are proteins capable of recognising and binding to specific oligosaccharide tructures found on glycoproteins and other biomoloecules. As such they have found tility for glycoanalytical applications.
Afrough, Aileen Creavin, Ambrosi, Andrews, Brendan O’Connor, Campbell, Charlwood, Chen, Debray, Drickamer, Duk, Dwek, Eisen, Geyer, Guile, Harvey, Hsu, Huber, Iskratsch, Jiménez-Barbero, Karamanska, Karlsson, Kim, Kirkeby, Kristiansen, Laemmli, Lis, Loris, Michael O’Connell, North, Olausson, Paul Clarke, Pilobello, Pilobello, Raman, Roisin Thompson, Rosenfeld, Royle, Rudd, Rudd, Rudd, Sparbier, Studentsov, Trimble, Varki, Wu, Wu, Wu, Wu   +48 more
core   +2 more sources

Glycoproteomic and glycomic databases [PDF]

Clinical Proteomics, 2014
Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases like cancer, cardiovascular diseases, neurological disorders, and immunological disorders. Emerging mass spectrometry (MS) technologies that enable
Baycin Hizal, Deniz, Wolozny, Daniel, Colao, Joseph, Jacobson, Elena, Tian, Yuan, Krag, Sharon S, Betenbaugh, Michael J, Zhang, Hui   +7 more
openaire   +2 more sources

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF)-Dependent Antiviral Responses Protect Mice against Ross River Virus Disease

mBio, 2022
Ross River virus (RRV) is the major mosquito-borne virus in the South Pacific region. RRV infections are characterized by arthritic symptoms, which can last from several weeks to months.
Xiang Liu, Adam Taylor, Yee Suan Poo, Wern Hann Ng, Lara J. Herrero, Patrick Chun Hean Tang, Ali Zaid, Suresh Mahalingam   +7 more
doaj   +1 more source

Discussion on the paper ‘Statistical contributions to bioinformatics: Design, modelling, structure learning and integration’ by Jeffrey S. Morris and Veerabhadran Baladandayuthapani [PDF]

, 2017
Bioinformatics is an important research area for statisticians. This discussion provides some additional topics to the paper, namely on statistical contributions to detect differential expressed genes, for protein structure prediction, and for the ...
Aitchison J, Arief Gusnanto, Benjamini Y, Hae Won Uh, Jeanine J Houwing-Duistermaat, Walt D   +5 more
core   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Non‐canonical glycopeptides of the proteoglycan linkage region are accessible by the enzymes B3GalT6 and GlcAT‐1 confirming a recently discovered rescue mode in glycosaminoglycan (GAG) biosynthesis. The crystal structure of B3GalT6 revealed a covalent dimer linked by a disulfide. Abstract We selected the N,O‐glycosylated proteoglycan bikunin as a model
Sascha Weidler, Ole Bundgaard, Markus Hessefort, Marisa Rädisch, Christopher Günther Franz Graf, Kevin Lam, Vanessa J. Neubauer, Johanna Eisenreich, Leonhard Köhler, Kelley W. Moremen, Catharina Steentoft, Henrik Clausen, Teng‐Yi Huang, Shang‐Cheng Hung, Clemens Steegborn, Michael Weyand, Carlo Unverzagt   +16 more
wiley   +2 more sources