Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete [PDF]
Frontiers in Microbiology, 2021 Dalbavancin, vancomycin and chlorobiphenyl-vancomycin share a high degree of structural similarity and the same primary mode of drug action. All inhibit bacterial cell wall biosynthesis through complexation with intermediates in peptidoglycan ...
Andy Hesketh +3 more
doaj +2 more sources
Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production [PDF]
Antibiotics, 2023 Teicoplanin and A40926 (natural precursor of dalbavancin) are clinically relevant glycopeptide antibiotics (GPAs) produced by Actinoplanes teichomyceticus NRRL B-16726 and Nonomuraea gerenzanensis ATCC 39727.
Andrés Andreo-Vidal +3 more
doaj +2 more sources
Antimicrobial Activity of Nanoconjugated Glycopeptide Antibiotics and Their Effect on Staphylococcus aureus Biofilm [PDF]
Frontiers in Microbiology, 2021 In the era of antimicrobial resistance, the use of nanoconjugated antibiotics is regarded as a promising approach for preventing and fighting infections caused by resistant bacteria, including those exacerbated by the formation of difficult-to-treat ...
Francesca Berini +7 more
doaj +2 more sources
Molecular dynamics simulations of the secondary-binding site in disaccharide-modified glycopeptide antibiotics [PDF]
Scientific Reports, 2022 Oritavancin is a semisynthetic glycopeptide antibiotic used to treat severe infections by multidrug-resistant Gram-positive pathogens. Oritavancin is known to be a thousand times more potent than vancomycin against Gram-positive bacteria due to the ...
Olatunde P. Olademehin +2 more
doaj +2 more sources
Developments in Glycopeptide Antibiotics. [PDF]
ACS Infect Dis, 2018 Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced. New, more potent semisynthetic derivatives that have entered the clinic, such as dalbavancin and oritavancin, have superior ...
Blaskovich MAT +5 more
europepmc +5 more sources
A Silkworm Infection Model for In Vivo Study of Glycopeptide Antibiotics [PDF]
Antibiotics, 2020 Glycopeptide antibiotics (GPAs) are drugs of last resort for treating infections by Gram-positive bacteria. They inhibit bacterial cell wall assembly by binding to the d-Ala-d-Ala terminus of peptidoglycan precursors, leading to cell lysis.
Aurora Montali +7 more
doaj +2 more sources
Old and New Glycopeptide Antibiotics: Action and Resistance [PDF]
Antibiotics, 2014 Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile.
Elisa Binda +2 more
doaj +2 more sources
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics [PDF]
Nature Communications, 2019 Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to the
Anja Greule +18 more
doaj +2 more sources
The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system. [PDF]
Antimicrob Agents Chemother, 2014 Glycopeptide antibiotics containing a hydrophobic substituent display the best activity against vancomycin-resistant enterococci, and they have been assumed to be poor inducers of the resistance system.
Kwun MJ, Hong HJ.
europepmc +3 more sources
Регуляторные исследования и экспертиза лекарственных средств, 2023 In recent years, glycopeptide antibiotics have been widely used to treat severe bacterial infections. The long-term use of first-generation antibiotics of this group (vancomycin, teicoplanin) has contributed to the emergence of bacteria resistant to them.
O. N. Vysochanskaya +2 more
doaj +1 more source